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E.G. Saravolac, O. Ludkovski, R. Skirrow, M. Ossanlou, Y.P. Zhang, C. Giesbrecht, J. Thompson, S. Thomas, H. Stark, P.R. Cullis, and P. Scherrer. Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentrations for optimal transfection activity. J. Drug Targeting 7, 423-437 (2000).

M.A. Monck, A. Mori, D. Lee, P. Tam, J.J. Wheeler, P.R. Cullis. Stabilized Plasmid-Lpid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumours Following Intravenous Injection. J. Drug Targeting 7, 439-452 (2000).

A. MacLachlan, P.R. Cullis and R.W. Graham. Synthetic Virus Systems for Systemic Gene Therapy. in Gene Therapy: Therapeutic Mechanisms and Strategies (N. Smythe-Templeton and D. Lasic, eds), Marcel Dekker, N.Y., Ch.13, p. 267-290 (2000).

I.M. Hafez and P.R. Cullis. Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behaviour. Biochim. Biophys. Acta 1463, 107-114 (2000).

A.M.I. Lam and P.R. Cullis. Calcium Enhances the Transfection Potency of Cationic Liposome-Plasmid DNA Complexes. Biochim. Biophys. Acta 1463, 279-290 (2000).

P. Tam, M. Monck, D. Lee, O. Ludkovski, E.C. Leng, K. Clow, H. Stark, P. Scherrer, R.W. Graham and P.R. Cullis. Stabilized Plasmid-Lipid Particles for Systemic Gene Therapy. Gene Therapy 7, 1867-1874 (2000).

T. Chen, K.F. Wong, D. B. Fenske, L. R. Palmer and P.R. Cullis. Fluorescently Labelled Poly(ethylene glycol) Lipid Conjugates With Distal Cationic Headgroups. Bioconjugate Chemistry 11, 433-437 (2000).

C. Oja, P. Tardi, M.P. Redelmeier and P.R. Cullis. Doxorubicin Entrapped Within Liposome-Associated Antigens Results in a Selective Inhibition of the Antibody Response to the Linked Antigen. Biochim. Biophys. Acta 1468, 31-40 (2000).

I.M. Hafez, S. Ansell and P.R. Cullis. Tunable pH Sensitive Liposomes Composed of Mixtures of Cationic and Anionic Lipids. Biophys. J. 79, 1438-1446 (2000).

P.R. Cullis. “Liposomes by Accident” (A.D. Bangham award lecture). J. Liposome Res. 10, ix-xxiv (2000).

P. Scherrer, N. Maurer, M. Monck, E. Saravolac, Y.P. Zhang, J. Wheller, P. Tam, A. Lam and P. R. Cullis. Design and Properties of a Lipid-Based Carrier System for Systemic Gene Therapy. in Targeting of Drugs: Strategies for Gene Constructs and Delivery (G. Gregoriadis and B. McCormack, eds), NATO Science Series A: Life Sciences Vol. 323, p. 165-185, IOS Press, Ohmsha (2000).

S.M. Ansell, T.O. Harasym, P.G. Tardi, S.S. Buchkowsky, M.B. Bally and P.R. Cullis. Antibody Conjugation Methods for the Active Targeting of Liposomes. Methods in Molecular Medicine 25, 51-68 (2000).

S.C. Semple, S.K. Klimuk, T.O. Harasym, N. Dos Santos, S.M. Ansell, K.F. Wong, N. Maurer, H. Stark, P.R. Cullis, M.J. Hope, and P. Scherrer. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochim. Biophys. Acta 1510, 152-166 (2001).

D.B. Fenske, I. MacLachlan and P.R. Cullis. Long-Circulating Vectors for the Systemic Delivery of Genes. Current Opinion in Molecular Therapeutics 3, 153-158 (2001).

N. Maurer, K.F. Wong, H. Stark, L. Louie, D. McIntosh, T. Wong, P. Scherrer, S. Semple and P.R. Cullis. Spontaneous Entrapment of Polynucleotides Upon Electrostatic Interaction With Ethanol Destabilized Cationic Liposomes: Formation of Small Multilamellar Liposomes. Biophys. J. 80, 2310-2326 (2001).

D.B. Fenske, L.R. Palmer, T. Chen, K.F. Wong and P.R. Cullis. Cationic PEG Lipids Incorporated into Pre-Formed Vesicles Enhance Binding and Uptake into BHK Cells. Biochim. Biophys. Acta 78097, 1-14 (2001).

Hafez and P.R. Cullis. Roles of Lipid Polymorphism in Intracellular Delivery. Advanced Drug Delivery Reviews 47, 139-148 (2001).

Hafez, N. Maurer and P.R. Cullis. On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids. Gene Therapy 8, 1188-1196 (2001).

N. Maurer, D.B. Fenske and P.R. Cullis. Developments in Liposomal Drug Delivery Systems. Expert Opinion Biological Therapeutics 1, 1-33 (2001).

D.B. Fenske, I. MacLachlan and P.R. Cullis. Stabilized Plasmid-Lipid Particles: A Systemic Gene Therapy Vector. in Methods in Enzymology: Gene Therapy Methods (M. I. Phillips, ed.) 346, 36-71 (2002).

I.V. Zhigaltsev, K.F. Wong, N. Maurer and P.R. Cullis. Triggered Release of Doxorubicin Following Mixing of Cationic and Anionic Liposomes. Biochim. Biophys. Acta, 1565, 129-135 (2002).

P.R. Cullis. Stabilized plasmid-lipid particles for systemic gene therapy. Cell Mol Biol Lett. 2002;7(2):226.

J. Gaucheron, T. Wong, K.F. Wong, N. Maurer and P.R. Cullis. Synthesis and Properties of Novel Tetra- Alkyl Cationic Lipids. Bioconjugate Chemistry 13, 671-675 (2002).

L.R. Palmer, T. Chen, A.M.I. Lam, D.B. Fenske, K.F. Wong and P.R. Cullis. Transfection Properties of Stabilized Plasmid-Lipid Particles Containing Cationic PEG Lipids. Biochim. Biophys. Acta 1611, 204-216 (2003).

J. Finn, A. Lee, I. MacLachlan and P.R. Cullis. TAn Enhanced Autogene-based Dual Promoter Cytoplasmic Expression System Yields Increased Gene Expression In Vitro. Gene Therapy 11, 276-283 (2004).

T.M. Allen and P.R. Cullis. Drug Delivery Systems: Entering the Mainstream. Science 303, 1818-1822 (2004).

D.B. Fenske and P.R. Cullis. Liposomes: Models of Biological Membranes and Drug Delivery Systems. Physics in Canada 60, 187-194 (2004).

T. Chen, L. Palmer, D. B. Fenske, A. M. Lam, K. F. Wong and P. R. Cullis. Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake. J. Liposome Research 14, 155-173 (2004).

T. Chen, D. McIntosh, Y. He, J. Kim, D. A.Tirrell, P. Scherrer, D. B. Fenske, A. Sandhu and P. R. Cullis. Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pHdependent intracellular delivery of liposomal contents. Molecular Membrane Biology 21, 385-394 (2004).

I.M. Hafez and P.R. Cullis. Tunable pH-Sensitive Liposomes. Methods in Enzymology 387, 113-134 (2004).

D.B. Fenske and P.R. Cullis. Entrapment of Small Molecules and Nucleic Acid-Based Drugs in Liposomes. Methods in Enzymology 391, 7-39 (2005).

D. N. Waterhouse, M.B. Bally, L.D. Mayer, T.D. Madden, P.R. Cullis and M. Webb. Preparation, Characterization and Biological Analysis of Liposomal Formulations of Vincristine. Methods in Enzymology 391, 40-57 (2005).

S.A. Abraham, D.N. Waterhouse, L.D. Mayer, P.R. Cullis, T.D. Madden and M.B. Bally. The Liposomal Formulation of Doxorubicin. Methods in Enzymology, 391, 71-96 (2005).

E. Ambegia, S. Ansell, P.R. Cullis, J. Heyes, L. Palmer and I. MacLachlan. Stabilized plasmid-lipid particles containing PEG-diacyglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochim. Biophys. Acta 1669, 155-163 (2005).

I.V.Zhigaltsev, N. Maurer, Q. Ahkong, R. Leone, E. Leng, J. Wang, S.C. Semple and P. R. Cullis. Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention. J. Controlled Release 104, 103-11.

J.D. Finn, T. Wong and P.R. Cullis. Investigation of factors responsible for cell line cytoplasmic expression differences. BMC Molecular Biology, 6, 1471-2199 (2005).

S.C. Semple, R. Leone, J. Wang, E.C. Leng, S.K. Klimuk, M.L. Eisenhardt, Z. Yuan, K. Edwards, N. Maurer, M.J. Hope, P.R. Cullis and Q. Ahkong. Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity. J. Pharmaceutical Science 94,1024 - 1038 (2005).

A.P. Sandhu, A.M.I. Lam, D.B. Fenske, L.R. Palmer, M. Johnston and P.R. Cullis. Calcium enhances the transfection potency of stabilized plasmid-lipid particles. Analytical Biochemistry, 341, 156-64 (2005).

MacLachlan and P.R. Cullis. Diffusible-PEG-lipid Stabilized Plasmid Lipid Particles. In: Huang L, Wagner E, eds. Non-viral Vectors. New York: Elsevier; 2005. p. 157-188.

J. Finn, I. MacLachlan and P.R. Cullis. Factors limiting autogene-based cytoplasmic expression systems. FASEB J. 19, 608-610 (2005).

I.V. Zhigaltsev, N. Maurer, K. Edwards, G. Karlsson and P.R. Cullis. Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention. J. Controlled Release 110 (2006) 378-386.

M.J.W. Johnston, S.C. Semple, S.K. Klimuk, K. Edwards, M.L. Eisenhardt, E.C. Leng, G. Karlsson, D. Yanko and P.R. Cullis. Therapeutically Optimized Rates of Drug Release can be Achieved by Varying the Drug-to-Lipid Ratio in Liposomal Vincristine Formulations. Biochim. Biophys. Acta 1758 (2006) 55-64.

D.B. Fenske and P.R. Cullis. Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques. Liposome Technology, Vol. 2 (G. Gregoriadis, ed.) p. 27-50 (2006).

N. Maurer, I. Zhigaltsev and P.R. Cullis. Encapsulation of Nucleic Acid-Based Therapeutics. Liposome Technology, Vol. 2 (G. Gregoriadis, ed.) p. 131-148 (2006).

S. de Jong, G.G. Chikh, L.L. Sekirov, S. Raney, S.C. Semple, S.K. Klimuk, Z.N. Yuan, M. Hope, P.R. Cullis and Y.K. Tam. Encapsulation of CpG ODN in Liposomal Nanoparticles Enhances the Immunostimulatory, Adjuvant and Anti-tumour Activity of Subcutaneously Administered CpG ODN. Cancer Immunology and Immunotherapy 56 (2007) 1251-1264.

M.J.W. Johnston, S.C. Semple, S.K. Klimuk, S. Ansell, N. Maurer , P.R. Cullis. Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochim. Biophys. Acta 1768, 1121-1127 (2007).

J. de Jonge, J.M. Leenhouts, M. Holtrop, P. Schoen, P. Scherrer, P.R. Cullis, J. Wilschut, A. Huckriede. Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA. Biochem J. 2007 Jul 1;405(1):41-9.

K. D. Wilson, S.G. Raney, L. Sekirov, G. Chikh, S. de Yong, P.R. Cullis and Y.K. Tam. Effects of i.v. and s.c. Administration on the Pharmacokinetics, Biodistribution, Cellular Uptake and Immunostimulatory Activity of CpG Oligonucleotides Encapsulated in Liposomal Nanoparticles. International Immunopharmacology 7, 1064-1075 (2007).

M.S. Webb, N.L. Boman, D. Masin, D. Yapp, E. Ramsay, G.N.C. Chiu, P.R. Cullis and M.B. Bally. A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity. Lett. Drug Design and Discovery 4, 426-433 (2007).

D.B. Fenske and P.R. Cullis. Liposomal Nanomedicines. Expert Opinion in Drug Delivery 5, 25-44 (2008).

D.B. Fenske, A. Chonn, P.R. Cullis. Liposomal nanomedicines: an emerging field. Toxicol Pathol. 2008 Jan;36(1):21-9.

Y. Sun, S. Cressman, N. Fang, P.R. Cullis, D. Chen. Capillary Electrophoresis Frontal Analysis for Characterization of avß3 Integrin Binding Interactions. Analytical Chem 80, 3105-3111 (2008).

S.G. Raney, K.D. Wilson, L. Sekirov, G. Chikh, S.D. de Jong, P.R. Cullis and Y.K. Tam. The effect of circulation lifetime and drug:lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG ODN. J. Drug Targeting16, 564-577 (2008).

M. J.W. Johnston, K. Edwards, G. Karlsson, and P.R. Cullis. Influence of Drug-to-Lipid Ratio on Drug Release Properties and Liposome Integrity in Liposomal Doxorubicin Formulations. J. Liposome Res. 18, 145-152 (2008).

K.D. Wilson, S.D. de Jong, M.Kazem, R. Lall, M.J. Hope, P.R. Cullis, Y.K. Tam. The Combination Of Stabilized Plasmid Lipid Particles And Lipid Nanoparticle Encapsulated CpG Containing Oligodeoxynucleotides As A Systemic Genetic Vaccine. J Gene Med 11, 14–25 (2009).

S. Cressman, Y. Sun, E.J. Maxwell, N. Fang, D.D.Y. Chen and P.R. Cullis. Binding and Uptake of RGDContaining Ligands to Cellular avß3 Integrins. Int. J. Peptide Research & Therapeutics 15:49–59 (2009).

G. Chikh, S.D. de Jong, L. Sekirov, S.G. Raney, P.R. Cullis, J.P. Dutz and Y.K. Tam. Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles. International Immunology 21, 757-67 (2009).

S. Cressman, I. Dobson, J.B. Lee., Y.Y.C. Tam, P.R. Cullis. Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. Bioconjugate Chemistry 20, 1404-1411 (2009).

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