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I.V. Zhigaltsev, G. Winters, M. Srinivasulu, J. Crawford, M. Wong, L. Amankwa, D. Waterhouse, D. Masin, M. Webb, N. Harasym, L. Heller, M.B. Bally, M.A. Ciufolini, P.R. Cullis, N. Maurer. Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles. J. Control Release 144, 332-340 (2010).

S.C. Semple, A. Akinc, J. Chen, A.P. Sandhu, B.L. Mui, C.K. Cho, D.W. Sah, D. Stebbing, E.J. Crosley, E. Yaworski, I.M. Hafez, J.R. Dorkin, J. Qin, K. Lam, K.G. Rajeev, K.F. Wong, L.B. Jeffs, L. Nechev, M.L. Eisenhardt, M. Jayaraman, M. Kazem, M.A. Maier, M. Srinivasulu, M.J. Weinstein, Q. Chen, R. Alvarez, S.A. Barros, S. De, S.K. Klimuk, T. Borland, V. Kosovrasti, W.L. Cantley, Y.K. Tam, M. Manoharan, M.A. Ciufolini, M.A. Tracy, A. de Fougerolles, I. MacLachlan, P.R. Cullis, T.D. Madden, M.J. Hope. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6. Epub 2010 Jan 17.

S.D. de Jong, G. Basha, K.D. Wilson, M. Kazem, W. Jefferies, P.R. Cullis and Y.K. Tam. The immunostimulatory activity of unmethylated and methylated CpG ODN is dependent on their ability to colocalize with TLR9 in late endosomes. J. Immunology, 184, 6092-6102 (2010).

J.B. Lee, K. Zhang, Y.Y. Tam, Y.K. Tam, N.M. Belliveau, V.Y. Sung, P.J. Lin, E. Leblanc, M.A. Ciufolini, P.S. Rennie, P.R. Cullis. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. Int J Cancer. 2012 Sep 1;131(5):E781-90. doi: 10.1002/ijc.27361. Epub 2012 Jan 3.

G. Basha, T. I. Novobrantseva, N. Rosin, Y.Y.C. Tam, I. M. Hafez, M. K. Wong, T. Sugo, V. M. Ruda, J. Qin, B. Klebanov, M. Ciufolini, A. Akinc, Y. K. Tam, M. J. Hope and P. R. Cullis. Influence Of Cationic Lipid Composition On Gene Silencing Properties Of Lipid Nanoparticle Formulations Of siRNA In Antigen Presenting Cells. Molecular Therapy,19(12):2186-200 (2011).

P. Geetha-Loganathan, S. Nimmagadda, I. Hafez, K. Fu, P.R. Cullis, J.M. Richman. Development of high-concentration lipoplexes for in vivo gene function studies in vertebrate embryos. Dev Dyn. 2011 Sep;240(9):2108-19. doi: 10.1002/dvdy.22708. Epub 2011 Jul 29.

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids. 2012 Jan 24;1:e4. doi: 10.1038/mtna.2011.3.

Y.Y.C.Tam, S. Chen, J. Zaifman, Y.K. Tam, P.J. Lin, S. Ansell, M. Roberge, M. Ciufolini, and P. R. Cullis. Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine. 2012 Dec 6. pii: S1549-9634(12)00689-2. doi: 10.1016/j.nano.2012.11.006. [Epub ahead of print].

I.V. Zhigaltsev, N. Belliveau, I. Hafez, J. Huft, C.L. Hansen and P.R. Cullis. Bottom-up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores using Millisecond Microfluidic Mixing. Langmuir, 28(7):3633-40 (2012).

P.J.C Lin, Y.Y.C. Tam, I. Hafez, A. Sandhu, S. Chen, M. Ciufolini, R. Nabi, and P.R. Cullis. Influence Of Cationic Lipid Composition On Uptake And Intracellular Processing Of Lipid Nanoparticle Formulations Of siRNA In A Macrophage Cell Line. Nanomedicine, Epub ahead of print (2012).

N.M. Belliveau, J. Huft, P.J.C Lin, S. Chen, J. Lee, Y.K. Tam, C Hansen and P.R. Cullis. Microfluidic Synthesis of Highly Potent Limit-Size Lipid Nanoparticles for In Vivo Delivery of siRNA. Molecular Therapy-Nucleic Acids, Molecular Therapy–Nucleic Acids (2012) 1, e37.

A.K. Leung, I.M. Hafez, S. Baoukina, N.M. Belliveau, I. Zhigaltsev, E. Afshinmanesh, D.P. Tieleman, C.L. Hansen, M.J. Hope and P.R. Cullis. Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core. J. Phys. Chem. C 34, 18440-18450 (2012).

M. Jayaraman, S.M. Ansell, B.L. Mui, Y.K. Tam, J. Chen, X. Du, D. Butler, L. Eltepu, S. Matsuda, J.K. Narayanannair, K.G. Rajeev, I.M. Hafez, A. Akinc, M.A. Maier, M.A. Tracy, P.R. Cullis, T.D. Madden, M. Manoharan, M.J. Hope. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo. Angew Chem Int Ed Engl,Epub ahead of print (2012).

T.M.Allen and P.R. Cullis. Liposomal drug delivery systems: From concept to clinical applications. Advance Drug Delivery Reviews. Volume 65, Issue 1, Pages 1-148 (January 2013).

MA Maier, M Jayaraman, S Matsuda, J Liu, S Barros,W Querbes, YK Tam, SM Ansell, V Kumar, J Qin, X Zhang, Q Wang, S Panesar, R Hutabarat, M Carioto, J Hettinger, P Kandasamy, D Butler, KG Rajeev, B Pang, K Charisse, K Fitzgerald, BL Mui, X Du, P Cullis, TD Madden, MJ Hope, M Manoharan, A Akinc. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics. Mol Ther. 2013 Aug;21(8):1570-8. doi: 10.1038/mt.2013.124. Epub 2013 Jun 25.

YYC Tam, S Chen, PR Cullis. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013; 5(3):498-507.

C. Wan, T.M. Allen and P.R. Cullis. Lipid nanoparticle delivery systems for siRNA-based therapeutics. Drug Delivery and Translational Research. 2013; doi:10.1007/s13346-013-0161-z

B.L. Mui, Y.K. Tam, M. Jayaraman, S.M. Ansell, X. Du, Y.Y.C. Tam, P.J.C. Lin, S. Chen, J.K. Narayanannair, K.G. Rajeev, M. Manoharan, A. Akinc, M.A. Maier, P. Cullis, T.D. Madden, M.J. Hope. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy—Nucleic Acids (2013) 2, e139; doi:10.1038/mtna.2013.66

R.L. Rungta, H.B. Choi, P.J.C. Lin, R. Ko, D. Ashby, J. Nair, M. Manoharan, P.R. Cullis, B.A. MacVicar. Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Mol Ther Nucleic Acids. 2013 Dec 3;2:e136. doi: 10.1038/mtna.2013.65

U.H. Neumann, S. Chen, Y.Y.C. Tam, R.K. Baker, S.D. Covey, P.R. Cullis, and T.J. Kieffer. IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice. Endocrinology, 155(3):716-25 (2014)

C. Walsh, K. Ou, N.M. Belliveau, T.J. Leaver, A.W. Wild, J. Huft, P.J.C Lin, S. Chen, A.K. Leung, J.B. Lee, C.L. Hansen, R.J. Taylor, E.C. Ramsay, and P.R. Cullis. Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications. Methods Mol Biol. 2014;1141:109-20. doi: 10.1007/978-1-4939-0363-4_6

S. Chen, Y.Y.C. Tam, P.J.C. Lin, A.K.K. Leung, Y.K. Tam, P.R. Cullis. Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. J. Controlled Release 196 (2014) 106–112.

A.K.K. Leung, Y.Y.C. Tam, P.R. Cullis. Lipid Nanoparticles for Short Interfering RNA Delivery. Chapter Four-Advances in Genetics, Volume 88 ISSN 0065-2660.

R.L. Rungta, H.B. Choi, J.R. Tyson, A. Malik, L. Dissing-Olesen, P.J.C. Lin, S.M. Cain, P.R. Cullis, T.P. Snutch, B.A. MacVicar. The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema. Cell 161, 610–621, April 23, 2015.

I.V. Zhigaltsev, Y.K. Tam, A.K.K. Leung, P.R. Cullis. Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents. J. Liposome Research, Early Online: 1–7; DOI: 10.3109/08982104.2015.1025411.

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