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Last updated: May 2015

P.R. Cullis and J.R. Marko. Determination of the Donor Pair Exchange Energy in Phosphorus-Doped Silicon. Phys. Rev. B1, 632-637 (1970).

P.R. Cullis and J.R. Marko. Electron Paramagnetic Resonance Properties of n-Type Silicon in the Intermediate Impurity Concentration Range. Phys. Rev. B11, 4184-4200 (1975).

J.A. Berden, P.R. Cullis, D.I. Hoult, A.C. McLaughlin, G.K. Radda and R.E. Richards. Frequency Dependence of 31P NMR Linewidths in Sonicated Phospholipid Vesicles: Effects of Chemical Shift Anisotropy. FEBS Letters 46, 55-58 (1974).

J.A.C. McLaughlin, P.R. Cullis, J.A. Berden and R.E. Richards. 1P NMR of Phospholipid Membranes:Effects of Chemical Shift Anistropy at High Magnetic Field Strengths. J. Mag. Resonance 20, 146-165 (1975).

E. Sim, P.R. Cullis and R.E. Richards. Physical Studies on Phosphonium Phosphatidylcholine: A Unique 31P NMR Probe for Model and Biological Membranes. Biochem. J. 151, 555-560 (1975).

B. de Kruijff, P.R. Cullis and G.K. Radda. Differential Scanning Calorimetry and 31P NMR Studies on Sonicated and Unsonicated Phosphaditylcholine Liposomes. Biochim. Biophys. Acta 406, 6-20 (1975).

B. de Kruijff, P.R. Cullis, G.K. Radda and R.E. Richards. Phosphorus Nuclear Magnetic Resonance of Acholeplasma Laidlawii Cell Membranes and Derived Liposomes. Biochim. Biophys. Acta 419, 411-424 (1976).

P.R. Cullis. Electron Paramagnetic Resonance in Inhomogeneously Broadened Systems: A Spin Temperature Approach. J. Mag. Resonance 21, 397-418 (1976).

A.C. McLaughlin, P.R. Cullis, M.A. Hemminga, D.I. Hoult, G.K. Radda, P.J. Seeley and R.E. Richards. Application of 31P NMR to Model and Biological Systems. FEBS Letters 57, 213-218 (1975).

P.R. Cullis, B. de Kruijff and R.E. Richards. Factors Affecting the Motion of the Polar Headgroup in Phospholipid Bilayers: A 31P NMR Study of Unsonicated Phosphatidylcholine Liposomes. Biochim.Biophys. Acta 426, 433-446 (1976).

P.R. Cullis and B. de Kruijff. 31P NMR Studies of Unsonicated Aqueous Dispersions of Neutral and Acidic Phospholipids: Effects of Phase Transitions, 2H and Divalent Cations on the Motion in the Phosphate Region of the Polar Headgroup. Biochim. Biophys. Acta 436, 523-540 (1976).

B. de Kruijff, P.R. Cullis and G.K. Radda. Outside-Inside Distributions and Sizes of Mixed Phosphatidylcholine Cholesterol Vesicles. Biochim. Biophys. Acta 436, 729-740 (1976).

P.R. Cullis. Lateral Diffusion Rates of Phosphatidylcholine in Vesicle Membranes: Effects of Cholesterol and Hydrocarbon Phase Transitions. FEBS Letters 70, 223-228 (1976).

P.R. Cullis. Hydrocarbon Phase Transitions, Heterogeneous Lipid Distributions and Lipid-Protein Interactions in Erythrocyte Membranes. FEBS Letters 68, 173-176 (1976).

P.R. Cullis, B. de Kruijff, A.E. McGrath, C.G. Morgan and G.K. Radda. Lipid Asymmetry, Clustering and Molecular Motion in Biological Membranes and their Models. The Structure of Biological Membranes, Nobel Symposium No. 34 (Abrahamson, S. and Pascher, I. eds) Plenum Press, New York (1976).

P.R. Cullis and A.C. McLaughlin. Phosphorus Nuclear Magnetic Resonance Studies of Model and Biological Membrane Systems. Trends in Biochemical Sciences 2, 196-199 (1977).

A.C. McLaughlin, P.R. Cullis, M.A. Hemminga, F.F. Brown and J. Brocklehurst. Magnetic Resonance Studies of Model and Biological Membranes. In NMR in Biology (Dwek, R.A., Campbell, I.D., Richards, R.E. and Williams, R.J.P., Eds) Academic Press, London (1977).

E. Sim and P.R. Cullis. 31P NMR Studies of Cell Membranes Labelled with Phosphonium Phosphatidylcholine. FEBS Letters 79, 340-345 (1977).

P.R. Cullis and Ch. Grathwohl. Hydrocarbon Phase Transitions and Lipid-Protein Interactions in the Erythrocyte Membrane: A 31P NMR and Fluorescence Study. Biochim. Biophys. Acta 471, 213-226 (1977).

P.R. Cullis and B. de Kruijff. Polymorphic Phase Behaviour of Lipid Mixtures as Detected by 31P NMR: Evidence that Cholesterol may Destabilize Bilayer Structure in Membrane Systems Containing Phosphatidylethanolamines. Biochim. Biophys. Acta 507, 207-218 (1978).

P.R. Cullis and M.J. Hope. Effects of Fusogenic Agents on the Membrane Structure of Erythrocyte Ghosts and the Mechanism of Membrane Fusion. Nature 271, 672-675 (1978).

P.R. Cullis, A.J. Verkleij and P.H.J. Th. Ververgaert. Polymorphic Phase Behaviour of Cardiolipin as Detected by 31P NMR and Freeze Fracture Techniques: Effects of Ca2+, Dibucaine and Chlorpromazine. Biochim. Biophys. Acta 513, 11-20 (1978).

B. de Kruijff, A.H.M.P. van den Besselaar, P.R. Cullis, H. van den Bosch and L.L.M. van Deenen. Evidence for Isotropic Motion of Phospholipids in Liver Microsomal Membranes: A 31P NMR Study. Biochim. Biophys. Acta 514, 1-8 (1978).

P.R. Cullis, P.W.M. van Dijck, B. de Kruijff and J. de Gier. Effects of Cholesterol on the Properties of Equimolar Mixtures of Synthetic Phosphatidylethanolamine and Phosphatidylcholine: A 31P NMR and Differential Scanning Calorimetry Study. Biochim. Biophys. Acta 513, 21-30 (1978).

P.R. Cullis and B. de Kruijff. The Polymorphic Phase Behaviour of Phosphatidylethanolamine of Natural and Synthetic Origin: A 31P NMR Study. Biochim. Biophys. Acta 513, 31-42 (1978).

P.R. Cullis and A.J. Verkleij. Modulation of Membrane Structure by Ca2+ and Dibucaine. Biochim. Biophys. Acta 552, 546-551 (1979).

P.R. Cullis and B. de Kruijff. Lipid Polymorphism and the Functional Roles of Lipids in Biological Membranes. Biochim. Biophys. Acta 559, 399-420 (1979).

A.J. Verkleij, C. Mombers, W.J. Gerritsen, J. Leunissen-Bijvelt and P.R. Cullis. Fusion of Phospholipid Vesicles in Association with the Appearance of Lipidic Particles as Visualized by Freeze-Fracturing. Biochim. Biochim. Biophys. Acta 555, 358-362 (1979).

M.J. Hope and P.R. Cullis. The Bilayer Stability of the Inner Monolayer Lipids of the Human Erythrocyte. FEBS Letters 107, 323-326 (1979).

P.R. Cullis, A.P. Hornby and M.J. Hope. Effects of Anaesthetics on Lipid Polymorphism. In: Molecular Mechanisms of Anaesthesia (Progress in Anaesthesiology, Vol. 2) (Fink, B.R., Ed.) Raven Press, New York, pp.397-404 (1980).

P.R. Cullis and M.J. Hope. The Bilayer Stabilizing Role of Sphingomyelin in the Presence of Cholesterol. Biochim. Biophys. Acta 597, 533-542 (1980).

M.J. Hope and P.R. Cullis. Effects of divalent cations and pH on phosphatidylserine model membranes: a 31P NMR study. Biochim. Biophys. Res. Comm. 92, 846-852 (1980).

B. de Kruijff, P.R. Cullis and A.J. Verkleij. Non-Bilayer Lipid Structures in Model and Biological Membranes. Trends Biochem. Sci. 5, 79-81 (1980).

B. de Kruijff, A. Rietveld and P.R. Cullis. 31P NMR Studies on Membrane Phospholipids in Microsomes, Rat Liver Slices and Intact Perfused Rat Liver. Biochim. Biophys. Acta 600, 343-357 (1980).

P.R. Cullis, B. de Kruijff, M.J. Hope, R. Nayar and A. Rietveld. Structural Properties of Phospholipids in the Rat Liver Mitochondrial Membranes: A 31P NMR Study. Biochim. Biophys. Acta 600, 625-635 (1980).

B. de Kruijff, G.A. Morris and P.R. Cullis. Application of 31P NMR Saturation Transfer Techniques to Model and Biological Membranes. Biochim. Biophys. Acta 598, 206-211 (1980).

A.J. Verkleij, C.J.A. van Echteld, W.J. Gerritsen, P.R. Cullis and B. de Kruijff. The Lipidic Particle as an Intermediate Structure in Membrane Fusion Processes and Bilayer to Hexagonal (HII) Transitions. Biochim. Biophys. Acta 600, 620-624 (1980).

P.R. Cullis, B. de Kruijff, M.J. Hope, R. Nayar and S.L. Schmid. Phospholipid and Membrane Transport. Can. J. Biochem. 58, 1091-1100 (1980).

B. de Kruijff and P.R. Cullis. Cytochrome c Specifically Induces Non-Bilayer Structures in Cardiolipin Containing Model Membranes. Biochim. Biophys. Acta 602, 477-490 (1980).

E.E. Burnell, P.R. Cullis and B. de Kruijff. Effects of Tumbling and Lateral Diffusion on Phosphatidylcholine Model Membrane 31P NMR Lineshapes. Biochim. Biophys. Acta 603, 63-69 (1980).

B. de Kruijff and P.R. Cullis. The Influence of Poly-L-lysine on Phospholipid Polymorphism. Evidence that Electrostatic Polypeptide-Phospholipid Interactions can Modulate Bilayer-Non-Bilayer Transitions. Biochim. Biophys. Acta 601, 235-242 (1980).

S.B. Farren and P.R. Cullis. Polymorphism of Phosphatidylglycerol-Phosphatidyl ethanolamine Model Membrane Systems: A 31P NMR Study. Biochem. Biophys. Res. Comm. 97, 182-191 (1980).

M.J. Hope and P.R. Cullis. The Role of Non-Bilayer Lipid Structure in the Fusion of Human Erythrocytes Induced by Lipid Fusogens. Biochim. Biophys. Acta 640, 82-90 (1981).

C.P.S. Tilcock and P.R. Cullis. The Polymorphic Phase Behaviour of Mixed Phosphatidylserine-ylethanolamine Model Systems as Detected by 31P NMR: Effects of Divalent Cations and pH. Biochim. Biophys. Acta 641, 189-201 (1981).

B. de Kruijff, A.J. Verkleij, C.J.A. van Echteld, W.J. Gerritsen, P.C. Noordam, C. Mombers, A. Rietveld, J.de Gier, P.R. Cullis, M.J. Hope and R. Nayar. Non-Bilayer Lipids and the Inner Mitochondrial Membrane. In: International Cell Biology 1980-81 (H.G. Schweiger, Ed.) Springer-Verlag Berlin, pp.559-571 (1981).

P.R. Cullis, S.B. Farren and M.J. Hope. 31P NMR Techniques and Membrane Lipid Structure: Implications for Mechanisms of Membrane Fusion. Can. J. Spectros. 26, 89-96 (1981).

A.P. Hornby and P.R. Cullis. Influence of Local and Neutral Anaesthetics on the Polymorphic Phase Preferences of Egg Yolk Phosphatidylethanolamine. Biochim. Biophys. Acta 647, 285-292 (1981).

B. de Kruijff, A.J. Verkleij, C.J.A. van Echteld, J. de Gier and P.R. Cullis. Lipid Polymorphism and the Occurrence of Non-Bilayer Phases in Model and Biological Membranes. In: Membranes and Intercellular Communication (Balian et al, Eds) pp.79-91 North Holland Publishing Co. (1981).

P.R. Cullis. Functional Significance of Non-Bilayer Lipid Structure. In: Composition and Functions of Cell Membranes in Application to the Pathophysiology of Muscle Diseases (S. Wolf and A.K. Murray, Eds) pp.137-154 Plenum Press N.Y. (1981).

C.P.S. Tilcock and P.R. Cullis. The Polymorphic Phase Behaviour and Miscibility Properties of Synthetic Phosphatidylethanolamines. Biochim. Biophys. Acta 684, 212-218 (1982).

T.D. Madden and P.R. Cullis. Stabilization of Bilayer Structure for Unsaturated Phosphatidylethanolamines by Detergents. Biochim. Biophys. Acta 684, 149-153 (1982).

B. de Kruijff, R. Nayar and P.R. Cullis. 31P NMR Studies on Phospholipid Structure in Membranes of Intact, Functionally Active Rat Liver Mitochondria. Biochim. Biophys. Acta 684, 47-52 (1982).

R. Nayar, S.L. Schmid, M.J. Hope and P.R. Cullis. Structural Preferences of Phosphatidylethanolamine Model Membranes: Influence of Ca2+ and Mg2+. Biochim. Biophys. Acta 688, 169-176 (1982).

M.A. Hemminga and P.R. Cullis. 31P NMR Studies of Oriented Phospholipid Multilayers. J. Mag. Resonance 47, 307-323 (1982).

R. Nayar M.J. Hope and P.R. Cullis. Phospholipids as Adjuncts for Ca2+ Stimulated Release of Chromaffin Granule Contents: Implications for Mechanisms of Exocytotic Release. Biochemistry 21, 4583-4590 (1982).

C.P.S. Tilcock, M.B. Bally, S.B. Farren and P.R. Cullis. Influence of Cholesterol on the Structural Preferences of Dioleoylphosphatidylethanolamine-Dioleoylphosphatidyl choline Systems: A 31P NMR and 2H NMR Study. Biochemistry 21, 4596-4602 (1982).

B. de Kruijff, P.R. Cullis and A.J. Verkleij. Structural and Functional Aspects of Non-Bilayer Lipids. In: Membranes and Transport, Vol.1 (A. Martinosi, Ed.) pp.43-49, Plenum Press, N.Y. (1982).

P.R. Cullis, B. de Kruijff, M.J. Hope, A.J. Verkleij, R. Nayar, S.B. Farren, C.P.S. Tilcock, T.D. Madden and M.B. Bally. Structural Properties of Lipids and Their Functional Roles in Biological Membranes. In: Membrane Fluidity in Biology, Vol. 1 (R.C. Aloia, Ed.) pp.39-81 Academic Press, N.Y. (1983).

M.B. Bally, C.P.S. Tilcock, M.J. Hope and P.R. Cullis. Polymorphism of Phosphatidylethanolamine-Phosphatidylserine Model Systems: Influence of Cholesterol and Mg2+ on Ca2+ Triggered Bilayer to Hexagonal (HII) Transitions. Can. J. Biochem. 61, 346-352 (1983).

S.B. Farren, M.J. Hope and P.R. Cullis. Polymorphic Phase Preferences of Phosphatidic Acid: A 31P and 2H NMR Study. Biochem. Biophys. Res. Commun. 111, 675-682 (1983).

M.J. Hope, D.C. Walker and P.R. Cullis. Ca2+ and pH Induced Fusion of Small Unilamellar Vesicles Consisting of Phosphatidylethanolamine and Negatively Charged Phospholipids: A Freeze-Fracture Study. Biochem. Biophys. Res. Commun. 110, 15-22 (1983).

T.D. Madden, M.J. Hope and P.R. Cullis. Lipid Requirements for Coupled Cytochrome Oxidase Vesicles. Biochemistry 22, 1970-1974 (1983).

B. de Kruijff, P.R. Cullis, A.J. Verkleij, M.J. Hope, C.J.A. van Echteld and T.F. Taraschi. Lipid Polymorphism and Membrane Fusion. In: Enzymes of Biological Membranes (A. Martinosi, Ed.) Plenum Press, N.Y., pp.131-204 (1984).

T.D. Madden, M.J. Hope and P.R. Cullis. Influence of Vesicle Size and Oxidase Content on Respiratory Control in Reconstituted Cytochrome Oxidase Vesicles. Biochemistry 23, 1413-1418 (1984).

C.P.S. Tilcock, M.B. Bally, S.B. Farren, P.R. Cullis and S.M. Gruner. Cation Dependent Segregation Phenomena and Phase Behaviour in Model Membrane Systems Containing Phosphatidylserine: Influence of Cholesterol and Acyl Chain Composition. Biochemistry 23, 2696-2703 (1984).

S.B. Farren, E. F. Sommerman and P.R. Cullis. Production of Specifically 2H-Labelled Unsaturated Phospholipids in Gram Quantities: A Convenient Synthesis of [11,11-2H2] Oleic Acid. Chem. Phys. Lipids 34, 279-286 (1984).

C.P.S. Tilcock, M.J. Hope and P.R. Cullis. Influence of Cholesterol Esters of Varying Unsaturation on the Polymorphic Phase Preferences of Egg Phosphatidylethanol amine. Chem. Phys. Lipids 35, 363-370 (1984).

T.D. Madden and P.R. Cullis. Detergent Induced Solubilization of Cytochrome c Oxidase as Detected in a Novel Reconstituted System. J. Biol. Chem. 259, 7655-7658 (1984).

E.F. Sommerman, P.H. Pritchard and P.R. Cullis. 125I-Labelled Inulin: A Convenient Marker for Deposition of Liposomal Contents In Vivo. Biochem. Biophys. Res. Commun. 122, 319-324 (1984).

R. Nayar, L.D. Mayer, M.J. Hope and P.R. Cullis. Phosphatidic Acid as a Calcium Ionophore in Large Unilamellar Vesicle Systems. Biochim. Biophys. Acta 777, 343-346 (1984).

A.J. Verkleij, J. Leunissen-Bijvelt, B. de Kruijff, M.J. Hope and P.R. Cullis. Non-Bilayer Structure and Membrane Fusion. Ciba Foundation Symposia 103, 45-54 (1984).

P.R. Cullis, M.J. Hope, R. Nayar, M.B. Bally and C.P.S. Tilcock. Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure. In: Phospholipids in the Nervous System, Vol. 2: Physiological Roles (L. Horrochs et al, Ed.) Raven Press, New York pp.71-86 (1985).

M.J. Hope, M.B. Bally, G. Webb and P.R. Cullis. Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure: Characterization of Size, Trapped Volume and Ability to Maintain a Membrane Potential. Biochim. Biophys. Acta 812, 55-65 (1985).

M.B. Bally, M.J. Hope, C.J.A. van Echteld and P.R. Cullis. Uptake of Safranine and Other Lipophilic Cations into Vesicles in Response to a Membrane Potential. Biochim. Biophys. Acta 812, 66-76 (1985).

L.D. Mayer, M.B. Bally, M.J. Hope and P.R. Cullis. Uptake of Dibucaine into Large Unilamellar Vesicles in Response to a Membrane Potential. J. Biol. Chem. 260, 802-808 (1985).

P.R. Cullis and M.J. Hope. Physical Properties and Functional Roles of Lipids in Membranes. In: Biochemistry of Lipids and Membranes (D.E. Vance and J.E. Vance, Eds) Benjamin Cummings, Menlo Park pp.25-72 (1985).

P.R. Cullis, M.J. Hope, B. de Kruijff, A.J. Verkleij and C.P.S. Tilcock. Structural Properties and Functional Roles of Phospholipids in Membranes. In: Phospholipids and Cellular Regulation (J.F. Kuo, Ed.) CRC Press, Boca Raton, Ch. 1, pp.1-60 (1985).

S.M. Gruner, P.R. Cullis, M.J. Hope and C.P.S. Tilcock. Lipid Polymorphism: The Molecular Basis of Non-Bilayer Phases. Ann. Rev. Biophys. and Biophys. Chem. 14, 211-238 (1985).

T.D. Madden and P.R. Cullis. Preparation of Reconstituted Cytochrome Oxidase Vesicles with Defined Trans-Membrane Protein Orientations Employing a Cytochrome c Affinity Column. Biochim. Biophys. Acta 808, 219-224 (1985).

L.D. Mayer, M.B. Bally, M.J. Hope and P.R. Cullis. Uptake of Antineoplastic Agents into Large Unilamellar Vesicles in Response to a Membrane Potential. Biochim. Biophys. Acta 816, 294-302 (1985).

T.D. Madden, M.B. Bally, M.J. Hope, P.R. Cullis, H.P. Schieren and A.S. Janoff. Protection of Large Unilamellar Vesicles by Trehalose during Lyophilization: Retention of Vesicle Contents. Biochim. Biophys. Acta 817, 67-74 (1985).

Y.Z. Zhang, R.A. Capaldi, P.R. Cullis and T.D. Madden. Orientation of Cytochrome c Oxidase Molecules in the Two Populations of Reconstituted Vesicles Resolved by Column Chromatography on DEAE Sephacryl. Biochim. Biophys. Acta 808, 209-211 (1985).

L.D. Mayer, M.J. Hope, P.R. Cullis and A.S. Janoff. Solute Distributions and Trapping Efficiencies Observed in Freeze-Thawed Multilamellar Vesicles. Biochim. Biophys. Acta 817, 193-196 (1985).

J. Rauch, M. Tannenbaum, H. Tannenbaum, H. Massicotte, H. Ramelson, P.R. Cullis, C.P.S. Tilcock, M.J.Hope and A.S. Janoff. Human Hybridoma Lupus Anticoagulants Distinguish between Lamellar and Hexagonal Phase Systems. J. Biol. Chem. 261, 9672-9677 (1986).

C.P.S. Tilcock, P.R. Cullis, M.J. Hope and S.M. Gruner. The Polymorphic Phase Behaviour of Unsaturated Lysophosphatidylethanolamines: A 31P NMR and X-Ray Diffraction Study. Biochemistry 25, 816-822 (1986).

P.R. Cullis, B. de Kruijff, A.J. Verkleij and M.J. Hope. Lipid Polymorphism and Membrane Fusion. Biochemical Society Transactions 14, 242-245 (1986).

L.D. Mayer, M.B. Bally and P.R. Cullis. Uptake of Adriamycin into Large Unilamellar Vesicles in Response to a pH Gradient. Biophys. Acta 857, 123-126 (1986).

L.D. Mayer, M.J. Hope and P.R. Cullis. Vesicles of Variable Sizes Produced by a Rapid Extrusion Procedure. Biochim. Biophys. Acta 858, 161-168 (1986).

R.L. Richards, R.C. Habbersett, I. Scher, A.S. Janoff, H.P. Schieren, L.D. Mayer, P.R. Cullis and C.R. Alving. Influence of Vesicle Size on Complement-Dependent Immune Damage to Liposomes. Biochim. Biophys. Acta 855, 223-230 (1986).

C.P.S. Tilcock, P.R. Cullis and S.M. Gruner. On the Validity of 31P NMR Identifications of Phospholipid Phase Behaviour. Chem. Phys. Lipids 40, 47-56 (1986).

M.J. Hope, M.B. Bally, L.D. Mayer, A.S. Janoff and P.R. Cullis. Generation of Multilamellar and Unilamellar Phospholipid Vesicles. Chem. Phys. Lipids 40, 89-108 (1986).

P.R. Cullis, M.J. Hope and C.P.S. Tilcock. Lipid Polymorphism and the Roles of Lipids in Membranes. Chem. Phys. Lipids 40, 127-144 (1986).

L.D. Mayer, M.B. Bally, M.J. Hope and P.R. Cullis. Techniques for Encapsulating Bioactive Agents into Liposomes. Chem. Phys. Lipids 40, 333-346 (1986).

J. Rauch, H. Tannenbaum, J.L. Senécal, A.S. Janoff, P.R. Cullis, M.M.Frojmovic MM. Polyfunctional properties of hybridoma lupus anticoagulant antibodies. J Rheumatol Suppl. 1987 Jun;14 Suppl 13:132-7.

M.J. Hope, P.R. Cullis. Lipid Asymmetry Induced by Transmembrane pH Gradients in Large Unilamellar Vesicles. J. Biol. Chem. 262, 4360-4366 (1987).

P.R. Cullis, M.J. Hope, M.B. Bally, A.S. Janoff, T.D. Madden and L.D. Mayer. Liposomes as Pharmaceuticals. In: Liposomes (M. Ostro, Ed.), Marcel Dekker, NY pp. 39-72 (1987).

T.D. Madden, M.J. Hope and P.R. Cullis. Modeling the Biological Membrane. Biochemical Society Transactions 15, 75-77 (1987).

C.P.S. Tilcock and P.R. Cullis. Lipid Polymorphism. Ann. NY Acad. Sci. 492, 88-101 (1987).

H.C. Loughrey, M.B. Bally and P.R. Cullis. A Non-Covalent Method of Attaching Antibodies to Liposomes. Biochim. Biophys. Acta 901, 157-160 (1987).

K.F. Wong, Y. Parmar, P.H. Pritchard and P.R. Cullis. Detection of Protein-Free Lipoprotein Analogues with an Apolar Lipid Core by Freeze-Etch Electron Microscopy. Biochim. Biophys. Acta 921, 411-414 (1987).

D.L. Sparke, J. Frolich, P.R. Cullis and P.H. Pritchard. Cholesteryl Ester Transfer Activity in Plasma Measured by Using Solid Phase Bound High Density Lipoprotein. Clinical Chemistry 33, 390-393 (1987).

S.M. Gruner, M.W. Tate, G.L. Kirk, P.T.C. So, D.C. Turner, C.P.S. Tilcock and P.R. Cullis. X-ray Diffraction Study of the Polymorphic Behaviour of N-Methylated Dioleoylphosphatidylcholine. Biochemistry 27, 2853-2866 (1988).

R. Nayar, C.P. Tilcock, M.J. Hope, P.R. Cullis, A.J. Schroit. N-succinyldioleoylphosphatidylethanolamine: structural preferences in pure and mixed model membranes. Biochim Biophys Acta. 1988 Jan 13;937(1):31-41.

C.P.S. Tilcock, P.R. Cullis and S.M. Gruner. Calcium Induced Phase Separation Phenomena in Multicomponent Unsaturated Lipid Mixtures. Biochemistry 27, 1415-1420 (1988).

M.B. Bally, M.J. Hope, L.D. Mayer, T.D. Madden and P.R. Cullis. Novel Procedures for Generating and Loading Liposomal Systems. In: Liposomes as Drug Carriers: Recent Trends and Progress (G. Gregoriadis, ed.), John Wiley & Sons Ltd, pp.841-853 (1988).

L.D. Mayer, K. Wong, K. Menon, C. Chong, P.R. Harrigan and P.R. Cullis. Influence of Ion Gradients on the Transbilayer Distribution of Dibucaine in Large Unilamellar Vesicles. Biochemistry 27, 2053-2060 (1988).

R. Nayar, C.P.S. Tilcock, M.J. Hope, P.R. Cullis and A.J. Schroit. N-Succinyldioleoylphosphatidylethanolamine: Structural Preferences in Pure and Mixed Model Membranes. Biochim. Biophys. Acta 937, 31-41 (1988).

M.B. Bally, L.D. Mayer, H. Loughrey, T. Redelmeier, T.D. Madden, K. Wong, P.R. Harrigan, M.J. Hope and P.R. Cullis. Dopamine Accumulation in Large Unilamellar Vesicle Systems Induced by Transmembrane Ion Gradients. Chem. Phys. Lipids 47, 97-107 (1988).

A.S. Janoff, C.L. Kurtz, R.L. Jablonski, S.R. Minchey, L.T. Boni, S.M. Gruner, P.R. Cullis, L.D. Mayer and M.J. Hope. Characterization of Cholesterol Hemisuccinate and Alpha Tocopherol Hemisuccinate Vesicles. Biochim. Biophys. Acta 941, 165-175 (1988).

A.S. Janoff, L.T. Boni, M.C. Popescu, S.R. Minchey, P.R. Cullis, T.D. Madden, T. Taraschi, S.M. Gruner, E. Shyamsunder, M.W. Tate, R. Mendelsohn and D. Bonner. Unusual Lipid Structures Selectively Reduce the Toxicity of Amphotericin B. Proc. Natl Acad. Sci. USA 85, 6122-6126 (1988).

Y.I. Parmar, D.L. Sparks, J. Frohlich, P.R. Cullis, P.H. Pritchard. Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy. J Lipid Res. 1989 May;30(5):765-71.

C.P.S. Tilcock, E.F. Sommerman, R.S. Molday and P.R. Cullis. Magnetic Filtration of Vesicles Containing Iron-Dextran Particles. J. Liposome Research 1, 137-150 (1988).

E. Sternin, B. Fine, M. Bloom, C.P.S. Tilcock, K.F. Wong and P.R. Cullis. Acyl Chain Orientational Order in the Hexagonal HII Phase of Phospholipid-Water Dispersions. Biophys. J. 54, 689-694 (1988).

T.D. Madden, C.P.S. Tilcock, K.F. Wong and P.R. Cullis. Spontaneous Vesiculation of Large Multilamellar Vesicles Composed of Saturated Phosphatidylcholine and Phosphatidylglycerol Mixtures. Biochemistry 27, 8724-8730 (1988).

L.W. Reinish, M.B. Bally, H.C. Loughrey and P.R. Cullis. Interactions of Liposomes and Platelets. Thrombosis and Haemostasis 60, 518-523 (1988).

J. Balazsovits, L.D. Mayer, M.B. Bally, P.R. Cullis, R.S. Ginsberg and R. Falk. Analysis of the Effect of Liposome Encapsulation on the Vesicant Properties, Acute and Cardiac Toxicities and Antitumour Efficacy of Doxorubicin. Cancer Chemotherapy and Pharmacology 23, 81-86 (1989).

C.P.S. Tilcock, P.R. Cullis, T. Dempsey, B. Youens and D. Fisher. Aqueous Two-Phase Polymer Partitioning of Lipid Vesicles of Defined Size and Composition. Biochim. Biophys. Acta 979, 208-214 (1989).

T.E. Redelmeier, L.D. Mayer, K.F. Wong, M.B. Bally and P.R. Cullis. Proton Flux in Large Unilamellar Vesicles in Response to Electrical Potentials and pH Gradients. Biophys. J., 56, 385-393 (1989).

M.J. Hope, T.E. Redelmeier, K.F. Wong, W. Rodrigueza and P.R. Cullis. Phospholipid Asymmetry in Large Unilamellar Vesicles Induced by Transmembrane pH Gradients. Biochemistry 28, 4181-4187 (1989).

S.J. Eastman, J. Wilschut, P.R. Cullis and M.J. Hope. Intervesicular Exchange of Lipids with Weak Acid and Weak Base Characteristics: Influence of Transmembrane pH gradients. Biochim. Biophys. Acta 981, 178-184 (1989).

M.J. Ostro and P.R. Cullis. Use of Liposomes as Injectable Drug Delivery Systems. BAm. J. Hosp. Pharm. 46, 1576-1587 (1989).

C.M. Doerschuk, R.P. Gie, M.B. Bally, P.R. Cullis and L.W. Reinish. Platelet Distribution in Rabbits Following Infusion of Liposomes. Thrombosis and Haemostasis 61, 392-396 (1989).

L.D. Mayer, L.C. Tai, D.S.C. Ko, D. Masin, R.S. Ginsberg, P.R. Cullis and M.B. Bally. Influence of Vesicle Size, Lipid Composition and Drug-to-Lipid Ratio on the Biological Activity of Liposomal Doxorubicin. Cancer Res. 49, 5922-5930 (1989).

E. C. Unger, P. MacDougall, P.R. Cullis, C. Tilcock. Liposomal Gd-DTPA: Effect of encapsulation on enhancement of hepatoma model by MRI. Magnetic Resonance Imaging, Volume 7, Issue 4, July–August 1989, Pages 417-423.

P.R. Cullis, L.D. Mayer, M.B. Bally, T.D. Madden and M.J. Hope. Generation and Loading of Liposomal Systems for Drug Delivery Applications. Advanced Drug Delivery Reviews, 3, 267-282 (1989).

M.J. Hope, K.F. Wong and P.R. Cullis. Freeze-Fracture of Lipids and Model Membrane Systems. AJ. Electron Microscopy Techniques 13, 277-287 (1989).

C.P.S. Tilcock, E. Unger, P.R. Cullis and P. MacDougall. Liposomal Gd-DTPA: Preparation and Characterization of Relaxivity. Radiology 171, 77-80 (1989).

M. Lafleur, B. Fine, E. Sternin, P.R. Cullis and M. Bloom. Smoothed Orientational Order Profile by 2HNMR. Biophys. J. 56, 1037-1041 (1989).

R. Nayar, M.J. Hope and P.R. Cullis. Generation of Large Unilamellar Vesicles from Long-Chain Saturated Phosphatidylcholines by Extrusion Techniques. Biochim. Biophys. Acta 986, 200-206 (1989).

C.P.S. Tilcock, R. Chin, J.A. Veiro, P.R. Cullis and D. Fisher. Detection of Surface Charge-Related Properties in Model Membrane Systems by Aqueous Two-Phase Partition. Biochim. Biophys. Acta 986, 167-171 (1989).

P.R. Harrigan, T.D. Madden and P.R. Cullis. Protection of Liposomes during Dehydration or Freezing. Chem. Phys. Lipids 52, 139-149 (1990).

T.D. Madden, P.R. Cullis and A.S. Janoff. Incorporation of Amphotericin B into Large Unilamellar Vesicles Composed of Phosphatidylcholine and Phosphatidylglycerol via Partition through an Aqueous Intermediate. Chem. Phys. Lipids 52, 189-198 (1990).

T.D. Madden, P.R. Harrigan, L.C. Tai, M.B. Bally, L.D. Mayer, T.E. Redelmeier, H.C. Loughrey, C.P.S. Tilcock, L.W. Reinish and P.R. Cullis. The Accumulation of Drugs within Large Unilamellar Vesicles Exhibiting a Proton Gradient: A Survey. Chem. Phys. Lipids 53, 37-46 (1990).

L.D. Mayer, M.B. Bally, H. Loughrey, D. Masin and P.R. Cullis. Liposomal Vincristine Preparations Which Exhibit Decreased Drug Toxicity and Activity Against Murine L1210 and P388 Tumors. Cancer Research 50, 575-579 (1990).

M. Lafleur, M. Bloom and P.R. Cullis. Lipid Polymorphism and Hydrocarbon Order. Biochemistry and Cell Biology 68, 1-8 (1990).

L.D. Mayer, M.B. Bally, P.R. Cullis, S.L. Wilson, J.T. Emerman. Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor. Cancer Lett. 1990 Sep;53(2-3):183-90.

L.D. Mayer, L.C.L. Tai, M.B. Bally, G.N. Mitilenes, R.S. Ginsberg and P.R. Cullis. Characterization of Liposomal Systems Containing Doxorubicin Entrapped in Response to pH Gradients. Biochim. Biophys. Acta 1025, 143-151 (1990).

M.B. Bally, R. Nayar, D. Masin, M.J. Hope, P.R. Cullis and L.D. Mayer. Liposomes with Entrapped Doxorubicin Exhibit Extended Blood Residence Times. Biochim. Biophys. Acta 1023, 133-139 (1990).

T.E. Redelmeier, M.J. Hope and P.R. Cullis. The Binding of Phosphatidylglycerol Liposomes to Rat Platelets is Mediated by Complement. Biochemistry 29, 3046-3053 (1990).

H.C. Loughrey, L. Choi, M.B. Bally and P.R. Cullis. Optimized Procedures for the Coupling of Proteins to Liposomes. J. Immunological Methods 132, 25-35 (1990).

H.C. Loughrey, M.B. Bally, K.F. Wong, L. Choi and P.R. Cullis. Protein-Liposome Conjugates with Defined Size Distributions. Biochim. Biophys. Acta 1028, 73-81 (1990).

H.C. Loughrey, M.B. Bally, L.W. Reinish and P.R. Cullis. The Binding of Phosphatidylglycerol Liposomes to Rat Platelets is Mediated by Complement. Thrombosis and Haemostasis 64, 172-176 (1990).

M.B. Bally, R. Nayar, D. Masin, P.R. Cullis and L.D. Mayer. Studies on the Myelosuppressive Activity of Doxorubicin Entrapped in Liposomes. Cancer Chemotherapy and Pharmacology 27, 13-19 (1990).

L.D. Mayer, M.B. Bally, P.R. Cullis, S.L. Wilson and J.T. Emerman. Comparison of Free and Liposome Encapsulated Doxorubicin Tumor Drug Uptake and Antitumor Efficacy in the SC115 Murine Mammary Tumor. Cancer Letters 53, 183-190 (1990).

J.A. Veiro and P.R. Cullis. A Novel Method for the Efficient Entrapment of Ca2+ in Large Unilamellar Vesicles. Biochim. Biophys. Acta 1025, 109-115 (1990).

L.T. Boni, W.R. Perkins, S.R. Minchey, L.E. Bolcsak, S.M. Gruner, P.R. Cullis, M.J. Hope and A.S. Janoff. Polymorphic Phase Behaviour of Alpha Tocopherol Hemisuccinate. Chem. Phys. Lipids 54, 193-203 (1990).

L.D. Mayer, M.B. Bally and P.R. Cullis. Strategies for Optimizing Liposomal Doxorubicin. J. Liposome Res. 1, 463-480 (1990).

R.L. Thies, W. Cowens, P.R. Cullis, M.B. Bally and L.D. Mayer. Method for Rapid Separation of Liposome-Associated Doxorubicin from Free Doxorubicin in Plasma. Anal. Biochem. 188, 65-71 (1990).

M. Lafleur, P.R. Cullis, B. Fine and M. Bloom. Comparison of the Orientational Order of Lipid Chains in the L-alpha and the HII Phases. Anal. Biochem. 188, 65-71 (1990).

M. Lafleur, P.R. Cullis and M. Bloom. Modulation of the orientational order profile of the lipid acyl chain in the L alpha phase. European J. Biophysics 19, 55-62 (1990).

A.C. Chakrabarti, J.A. Veiro, N. Wong, P.R. Cullis. Use of transmembrane pH gradients and A23187 to produce dense iron liposomes. Biochem Soc Trans. 1990 Oct;18(5):946-7.

P.R. Cullis, C.P. Tilcock and M.J. Hope. Lipid Polymorphism. In Membrane Fusion (J. Wilschut and D. Hoeckstra, Eds) pp. 35-64, Marcel Dekker, N.Y. (1990).

S.J. Eastman, M.J. Hope and P.R. Cullis. Transbilayer Transport of Phosphatidic Acid in Response to Transmembrane pH Gradients. Biochemistry 30, 1740-1745 (1991).

A. Chonn, P.R. Cullis and D.V. Devine. The Role of Surface Charge in the Activation of the Classical and Alternative Pathways of Complement by Liposomes. J. Immunology 146, 4234-4241 (1991).

P.R. Cullis, M.B. Bally, T.D. Madden, L.D. Mayer and M.J. Hope. pH Gradients and Membrane Transport in Liposomal Systems. Trends in Biotechnology 9, 268-272 (1991).

A. Chonn, S.C. Semple and P.R. Cullis. Separation of Large Unilamellar Liposomes from Blood Components by a Spin Column Procedure: Towards Identifying Plasma Proteins which Mediate Liposome Clearance In Vivo. Biochim. Biophys. Acta 1070, 215-222 (1991).

A.C. Chakrabarti, I. Clarke-Lewis, P.R. Harrigan and P.R. Cullis. Uptake of Basic Amino Acids and Peptides into Liposomes in Response to Transmembrane pH Gradients. Biophys. J. 61, 228-234 (1992).

J. Wilschut, J. Scholma, S.J. Eastman, M.J. Hope and P.R. Cullis. Ca2+-Induced Fusion of Phospholipid Vesicles Containing Free Fatty Acids: Modulation by Transmembrane pH Gradients. Biochemistry 31, 2629-2636 (1992).

S.J. Eastman, M.J. Hope, K.F. Wong and P.R. Cullis. Influence of Phospholipid Asymmetry on Fusion Between Large Unilamellar Vesicles. Biochemistry 31, 4262-4268 (1992).

A.C. Chakrabarti, J.A. Viero, N.S. Wong, J.J. Wheeler and P.R. Cullis. Generation and Characterization of Iron- and Barium-Loaded Liposomes. Biochim. Biophys. Acta 1108, 233-239 (1992).

A. Chonn, S.C. Semple and P.R. Cullis. Association of Blood Proteins with Large Unilamellar Liposomes In Vivo: Relation to Circulation Lifetimes. J. Biol. Chem. 267, 18759-18765 (1992).

N. Kitson, M. Monck, K.F. Wong and P.R. Cullis. The Influence of Cholesterol-3-Sulphate on Phase Behaviour and Hydrocarbon Order in Model Membrane Systems. Biochim. Biophys. Acta 1111, 127-133 (1992).

M.A. Monck, M. Bloom, M. Lafleur, R.N.A.H. Lewis, R.N. McElhaney and P.R. Cullis. Influence of Lipid Composition on the Orientational Order in Acholeplasma laidlawii Strain B Membranes: A Deuterium NMR Study. Biochemistry 31, 10037-10043 (1992).

P.R. Harrigan, M.J. Hope, T.E. Redelmeier and P.R. Cullis. Determination of Transmembrane pH Gradients and Membrane Potentials in Liposomes. Biophys. J. 63, 1336-1345 (1992).

D.B. Fenske and P.R. Cullis. Chemical Exchange Between Lamellar and Non-Lamellar Phases. A One and Two-Dimensional 31P NMR Study. Biochim. Biophys. Acta 1108, 201-209 (1992).

A. Chonn and P.R. Cullis. Ganglioside GM1 and Hydrophilic Polymers Increase Liposome Circulation Times by Inhibiting the Association of Blood Proteins. J. Liposome Res. 2, 397-410 (1992).

M.J. Hope, R. Nayar, L.D. Mayer and P.R. Cullis. Reduction of Liposome Size and Preparation of Unilamellar Vesicles by Extrusion Techniques. In: Liposome Technology (G. Gregoriadis, Ed.) Vol. I, p.123 (1993).

L.D. Mayer, T.D. Madden, M.B. Bally and P.R. Cullis. pH Gradient-Mediated Drug Entrapment in Liposomes. In: Liposome Technology (G. Gregoriadis, Ed.) Vol. II, p. 27-44 (1993).

H.C. Loughrey, L.S. Choi, K.F. Wong, P.R. Cullis and M.B. Bally. Preparation of Streptavidin-Liposomes for Use in Ligand-Specific Targeting Applications. In: Liposome Technology (G. Gregoriadis, Ed.) Vol. III, p. 163-178 (1993).

B.L.S. Mui, P.R. Cullis, E.A. Evans and T.D. Madden. Osmotic Properties of Large Unilamellar Vesicles Prepared by Extrusion. Biophys. J. 64, 443-453 (1993).

M.A. Monck, M. Bloom, M. Lafleur, R.N.A.H. Lewis, R.N. McElhaney and P.R. Cullis. Evidence for Two Pools of Cholesterol in the Acholeplasma laidlawii Strain B Membrane: A Deuterium NMR and DSC Study. Biochemistry 32, 3081-3088 (1993).

D.B. Fenske and P.R. Cullis. Acyl Chain Orientational Order in Large Unilamellar Vesicles: Comparison with Multilamellar Liposomes. A 2H and 31P NMR Study. Biophys. J. 64, 1482-1491 (1993).

P.R. Harrigan, K.F. Wong, T.E. Redelmeier, J.J. Wheeler and P.R. Cullis. Accumulation of Doxorubicin and Other Lipophilic Amines Into Large Unilamellar Vesicles in Response to Transmembrane pH Gradients. Biochim. Biophys. Acta 1149, 329-338 (1993).

M.J. Parr, M.B. Bally and P.R. Cullis. The Presence of GM1 in Liposomes with Entrapped Doxorubicin Does Not Prevent RES Blockade. Biochim. Biophys. Acta 1168, 249-252 (1993).

N.L. Boman, L.D. Mayer and P.R. Cullis. Optimization of the Retention Properties of Vincristine in Liposomal Systems. Biochim. Biophys. Acta 1152, 253-258 (1993).

P.M. Kanter, G.A. Bullard, F.G. Pilkiewicz, L.D. Mayer, P.R. Cullis, Z.P. Pavelic. Preclinical toxicology study of liposome encapsulated doxorubicin (TLC D-99): comparison with doxorubicin and empty liposomes in mice and dogs. In Vivo. 1993 Jan-Feb;7(1):85-95.

N.L. Boman, P.R. Cullis, M.B. Bally and L.D. Mayer. Preclinical and Clinical Activity of Liposomal Doxorubicin. in: Liposomes in Biomedical Applications (Dr. P.N. Shek, Ed) HAP Academic Publishers, p.85-103 (1995).

L.D. Mayer, R. Nayar, R.L. Thies, N.L. Boman, P.R. Cullis and M.B. Bally. Identification of Vesicle Properties Which Enhance the Antitumour Activity of Liposomal Vincristine Against Murine L1210 Leukemia. Chemotherapy and Pharmacology 33, 17-34(1993).

L. Embree, K.A. Gelmon, A. Lohr, L.D. Mayer, A.J. Coldman, P.R. Cullis, W. Palaitis, F. Pilkiewicz, N.J. Hudon, J.R. Heggie and J.H. Goldie. Chromatographic Analysis and Pharmacokinetics of Liposome- Encapsulated Doxorubicin in Non-Small-Cell Lung Cancer Patients. J. of Pharmaceutical Sciences 82, 627-634 (1993).

D.V. Devine, K.F. Wong, L. Serrano, A. Chonn and P.R. Cullis. Liposome-Complement Interactions in Rat Serum: Implications for Liposome Survival Studies. Biochim. Biophys. Acta 1191, 43-51 (1994).

L-S.B. Mui, P.R. Cullis, P.H. Pritchard and T.D Madden. Influence of Plasma on the Osmotic Sensitivity of Large Unilamellar Vesicles Prepared by Extrusion. J.Biol.Chem 269, 7364-7370 (1994).

N.L. Boman, D. Masin, L.D. Mayer, P.R. Cullis and M.B. Bally. Liposomal Vincristine Which Exhibits Increased Drug Retention and Increased Circulation Longevity Cures Mice Bearing P388 Tumors. Cancer Res. 54, 2830-2833 (1994).

R.N.A.H. Lewis, R.N. McElhaney, M.A. Monck and P.R. Cullis. Studies of Highly Asymmetric Mixed- Chain Diacyl Phosphatidylcholines that Form Mixed-Interdigitated Gel Phases: Fourier Transform Infrared and 2H-NMR Spectroscopic Studies of Hydrocarbon Chain Conformation and Orientational Order in the Liquid-Crystalline State. Biophys. J. 67, 197-207 (1994).

J.J. Wheeler, J.A. Veiro and P.R. Cullis. Ionophore-Mediated Loading of Ca2+Into Large Unilamellar Vesicles in Response to Transmembrane pH Gradients. Molecular Membrane Biology, 11, 151-157 (1994).

A.C. Chakrabarti, I. Clark-Lewis and P.R. Cullis. Influence of Charge, Charge Distribution and Hydrophobicity on the Transport of Short Model Peptides into Liposomes in Response to Transmembrane pH Gradients. Biochemistry, 33, 8479-8485 (1994).

L.D. Mayer, P.R. Cullis and M.B. Bally. The Use of Transmembrane pH Gradient-Driven Drug Encapsulation in the Pharmacodynamic Evaluation of Liposomal Doxorubicin. J. Liposome Res. 4, 529-553 (1994).

M.B. Bally, D. Masin, L.D. Mayer, P.R. Cullis and R. Nayar. Transfer of Liposomal Drug Carriers from the Blood to the Peritoneal Cavity of Normal and Ascitic Tumor-bearing Mice. Cancer Chemoth and Pharmacol 34, 137-146 (1994).

M.J. Parr, S.M. Ansell, L. Choi and P.R. Cullis. Factors Influencing the Retention and Chemical Stability Poly(ethylene Glycol)-Lipid Conjugates Incorporated into Large Unilamellar Vesicles. Biochim. Biophys. Acta 1195, 21-30 (1994).

A.L. Bailey and P.R. Cullis. Modulation of Membrane Fusion by Asymmetric Transbilayer Distributions of Amino Lipids. Biochemistry 33, 12573-12580 (1994).

D.B. Fenske, M.A. Monck, M.J. Hope and P.R. Cullis. The Functional Roles of Lipids in Biological Membranes. in: Biomembranes, Vol. 1, JAI Press, p.1-28 (1995).

N.L. Boman, M.B. Bally, P.R. Cullis, L.D. Mayer, M.S. Webb. Encapsulation of vincristine in liposomes reduces its toxicity and improves its antitumor efficacy. J. Liposome Research, J. Liposome Research 5, 523-541(1995).

T.O. Harasym, P. Tardi, S.A. Longman, S.M. Ansell, M.B. Bally, P.R. Cullis and L.S.L. Choi. Poly(ethylene-glycol)-modified phospholipids prevent aggregation during covalent conjugation of proteins to liposomes. Bioconjugate Chemistry 6, 187 (1995).

B.L.S. Mui, H.-G. Dobereiner, T.D. Madden and P.R. Cullis. Influence of Transbilayer Area Asymmetry on the Morphology of Large Unilamellar Vesicles. Biophys. J. 69, 930-941 (1995).

A. Chonn, S.C. Semple and P.R. Cullis. B2-Glycoprotein I Associates with Very Rapidly Cleared Liposomes In Vivo, Suggesting a Major Role in the Immune Clearance of “Non-Self” Particles. J. Biol. Chem. 270, 25845-25849 (1995).

S.A. Longman, P.G. Tardi, M.J. Parr, L. Choi, P.R. Cullis and M.B. Bally. Accumulation of protein-coated liposomes in an extravascular site: Influence of increasing circulation lifetimes. J. Pharmacology and Experimental Therapeutics 275, 1177-1184 (1995).

A. Chonn and P.R. Cullis. Recent Advances in Liposome Drug Delivery Systems. Current Opinion in Biotechnology 6, 698-708 (1995).

P.R. Cullis and M.J. Hope. Liposomes, Dimitri Papahadjopoulos, and us. J. Liposome Research 5, 829-836 (1995).

S.A. Longman, P.R. Cullis and M.B. Bally. A Model Approach for Assessing Liposome Targeting In Vivo. Drug Delivery 2, 156-165 (1995).

S.A. Longman, P.R. Cullis, L. Choi, Gary de Jong and M.B. Bally . A two-step targeting approach for delivery of doxorubicin-loaded liposomes to tumour cells in vivo. Cancer Chemother Pharmacol 36,91-101 (1995).

D.B. Fenske and P.R. Cullis. Lipid Polymorphism. in: Encyclopedia of NMR (John Wiley & Sons, Ed) p. 2730-2735 (1996).

N.L. Boman, V.A. Tron, M.B. Bally and P.R. Cullis. Vincristine-Induced Dermal Toxicity is Significantly Reduced When The Drug is Given in Liposomes. Cancer Chemotherapy and Pharmacology 37, 351-355 (1996).

S.C. Semple, A. Chonn and P.R. Cullis. Influence of Cholesterol on the Association of Plasma Proteins with Liposomes. Biochemistry 35, 2521-2525 (1996).

J.W. Holland, C. Hui, P.R. Cullis and T.D. Madden. Poly(ethylene-glycol)-lipid Conjugates Regulate the Ca2+ Induced Fusion of Liposomes Composed of Phosphatidylethanolamine and Phosphatidylserine. Biochemistry 35, 2618-2624(1996).

J.W. Holland, P.R. Cullis and T.D. Madden. Poly(ethylene-glycol)-lipid Conjugates Promote Bilayer Formation in Mixtures of Non-Bilayer Forming Lipids. Biochemistry 35, 2610-2617 (1996).

C.D. Oja, S.C. Semple, A. Chonn and P.R. Cullis. Influence of Dose on Liposome Clearance: Role of Blood Proteins. Biochim et Biophys Acta 1281, 31-37 (1996).

P.G. Tardi, N.L. Boman and P.R. Cullis. Liposomal Doxorubicin. J. of Drug Targeting 4, 129-140 (1996).

M. Lafleur, M. Bloom, E.F. Eikenberry, S.M. Gruner, Y, Han and P.R. Cullis. Correlation Between Lipid Plane Curvature and Lipid Chain Order. Biophys. J., 70, 2747-2757 (1996).

P.R. Cullis, D.B. Fenske and M.J. Hope. Physical properties and functional roles of lipids in membranes. in: Biochemistry of Lipids, Lipoproteins, and Membranes (New Comprehensive Biochemistry Vol. 31) (Vance, D.E. and Vance, J.E., Eds) Elsevier Science, Amsterdam, pp.1-33 (1996).

P.R. Cullis, M.J. Hope, M.B. Bally, T.D. Madden, L.D. Mayer and D.B. Fenske. Influence of pH Gradients on the Transbilayer Transport of Drugs, Lipids, Peptides and Metal Ions into Large Unilamellar Vesicles. Biochim Biophys. Acta (Reviews on Biomembranes), 1331, 187-211 (1997).

A.L. Bailey and P.R. Cullis. Membrane Fusion with Cationic Liposomes: Effects of Target Membrane Lipid Composition. Biochemistry, 36, 1628-1634 (1997).

A.L. Bailey, M.A. Monck and P.R. Cullis. pH-Induced Destabilization of Lipid Bilayers by a Lipopeptide Derived from Influenza Hemagglutinin. Biochim. Biophys. Acta 1342, 232-244 (1997).

A.L. Bailey and P.R. Cullis. Liposome Fusion. in: Current Topics in Membranes, (Academic Press) Vol. 44, pp. 359-373 (1997).

T.O. Harasym, P.R. Cullis and M.B. Bally. Intratumor Distribution of Doxorubicin Following I.V. Administration of Drug Encapsulated in Egg phosphatidylcholine/Cholesterol Liposomes. Cancer Chemotherapy and Pharmacology 40, 308-317 (1997).

K.W.C. Mok and P.R. Cullis. Structural and Fusogenic Properties of Cationic Liposomes in the Presence of Plasmid DNA. Biophys. J., 73, 2534-2545 (1997).

P.G. Tardi, E.N. Swartz, T.O. Harasym, P.R. Cullis and M.B. Bally. An Immune Response to Ovalbumin Covalently Coupled to Liposomes is Prevented When the Liposomes Used Contain Doxorubicin. J. of Immunol. Methods 210, 137-148 (1997).

M.J. Parr, D. Masin, P.R. Cullis and M.B. Bally. Accumulation of Liposomal Lipid and Encapsulated Dororubicin in Murine Lewis Lung Carcinoma: The Lack of Beneficial Effects by Coating Liposomes with Poly(ethylene glycol). J. Pharmacol and Experimental Therapeutics 280, 1319-1327 (1997).

N.L. Boman, P.R. Cullis, L.D. Mayer, M.B. Bally and M.S. Webb. Liposomal Vincristine: The Role of Drug Retention in Therapeutically Optimized Anticancer Formulations. in: Long Circulating Liposomes: Old Drugs, New Therapeutics (M.C. Woodle, G. Storm, eds.) Landes Bioscience, Austin, TX pp.29-49 (1998).

A. Chonn and P.R. Cullis. Recent Advances in Liposome Technologies and Their Applications for Systemic Gene Delivery. Advanced Drug Delivery Reviews 30, 73-84 (1998).

L.D. Mayer, P.R. Cullis and M.B. Bally. Designing Therapeutically Optimized Liposomal Anticancer Delivery Systems: Lessons from Conventional Liposomes. in Medical Applications of Liposomes (Lasic and Papahadjopoulos, Eds.) Elsevier Science B.V., pp.231-257 (1998).

N. Maurer, K.F. Wong, M.J. Hope and P.R. Cullis. Anomalous Solubility Behaviour of the Antibiotic Ciprofloxacin Encapsulated in Liposomes. Biochim. Biophys. Acta 1374, 9-20 (1998).

S.C. Semple, A. Chonn and P.R. Cullis. Interactions of Liposomes and Lipid-Based Carrier Systems with Blood Proteins: Relation to Clearance Behaviour in vivo. Advanced Drug Delivery Reviews 32, 3-18 (1998).

S.L. Schmid, P.R. Cullis. Membrane sorting. Endosome marker is fat not fiction. Nature. 1998 Mar 12;392(6672):135-6.

A. Mori, A. Chonn, L.S. Choi, A. Israels, M.A. Monck and P.R. Cullis. Stabilization and Regulated Fusion of Liposomes Containing a Cationic Lipid Using Amphipathic Polyethyleneglycol Derivatives. J. Liposome Res. 8, 195-211 (1998).

B.C.L. Cheung, T.H.T. Sun, J.M. Leenhouts and P.R. Cullis. Loading of Doxorubicin into Liposomes by Forming Mn2+-Drug Complexes. JBiochim. Biophys. Acta 1414, 205-216 (1998).

D.B. Fenske, K.F. Wong, E. Maurer, N. Maurer, J.M. Leenhouts, N. Boman, L. Amankwa and P.R. Cullis. Ionophore-Mediated Uptake of Ciprofloxacin and Vincristine into Large Unilamellar Vesicles Exhibiting Transmembrane Ion Gradients. Biochim. Biophys. Acta 1414, 188-204 (1998).

M.S. Webb, D. Saxon, F.M.P. Wong, H.J. Lim, Z. Wang, M.B. Bally, L.S.L. Choi, P.R. Cullis and L.D. Mayer. Comparison of Different Hydrophobic Anchors Conjugated to Poly(ethylene glycol): Effects on the Pharmacokinetics of Liposomal Vincristine. Biochim. Biophys. Acta 1372, 272-282 (1998).

E. Maurer-Spurej, K.F. Wong, N. Maurer, D.B. Fenske and P.R. Cullis. Factors Influencing Uptake and Retention of Amino-Containing Drugs in Large Unilamellar Vesicles Exhibiting Transmembrane pH Gradients. Biochim. Biophys. Acta 1416, 1-10 (1999).

J.J. Wheeler, L. Palmer, M. Ossanlou, I. MacLachlan, R.W. Graham, M.J. Hope, P. Scherrer and P.R. Cullis. Stabilized Plasmid-Lipid Particles: Construction and Characterization. Gene Therapy 6, 271-281 (1999).

P. Schoen, A. Chonn, P.R. Cullis, J. Wilschut and P. Scherrer. Gene Transfer Mediated by Reconstituted Influenza Virus Envelopes Containing Cationic Lipid. Gene Therapy 6, 823-832 (1999).

K.W.C. Mok, A.M.I. Lam and P.R. Cullis. Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochimica et Biophysica Acta - Biomembranes 1419, 137-150 (1999).

Y.P. Zhang, L. Sekirov, E.G. Saravolac, P. Tardi, K. Clow, E. Leng, R. Sun, P.R. Cullis and P. Scherrer. Stabilized Plasmid-Lipid Particles for Regional Gene Therapy: Formulation and Transfection Properties. Gene Therapy 6, 1438-1447 (1999).

N. Maurer, A. Mori, L. Palmer, M.A. Monck, K.W.C. Mok, B. Mui, Q.F. Akhong, P.R. Cullis. Lipid-based systems for the intracellular delivery of genetic drugs. Molecular Membrane Biology 16, 129-140 (1999).

A. MacLachlan, P. R. Cullis and R. W. Graham. Progress towards a synthetic virus for systemic gene therapy. Curr. Opinion in Molecular Therapeutics 1, 252-259 (1999).

T. Chen, L.S. Choi, S. Einstein, M.A. Klippenstein, P. Scherrer and P.R. Cullis. Proton-Induced Permeability and Fusion of Large Unilamellar Vesicles by Covalently Conjugated Poly(2-ethylacrylic Acid). J. Liposome Research 9, 387-405 (1999).

E.G. Saravolac, O. Ludkovski, R. Skirrow, M. Ossanlou, Y.P. Zhang, C. Giesbrecht, J. Thompson, S. Thomas, H. Stark, P.R. Cullis, and P. Scherrer. Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentrations for optimal transfection activity. J. Drug Targeting 7, 423-437 (2000).

M.A. Monck, A. Mori, D. Lee, P. Tam, J.J. Wheeler, P.R. Cullis. Stabilized Plasmid-Lpid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumours Following Intravenous Injection. J. Drug Targeting 7, 439-452 (2000).

A. MacLachlan, P.R. Cullis and R.W. Graham. Synthetic Virus Systems for Systemic Gene Therapy. in Gene Therapy: Therapeutic Mechanisms and Strategies (N. Smythe-Templeton and D. Lasic, eds), Marcel Dekker, N.Y., Ch.13, p. 267-290 (2000).

I.M. Hafez and P.R. Cullis. Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behaviour. Biochim. Biophys. Acta 1463, 107-114 (2000).

A.M.I. Lam and P.R. Cullis. Calcium Enhances the Transfection Potency of Cationic Liposome-Plasmid DNA Complexes. Biochim. Biophys. Acta 1463, 279-290 (2000).

P. Tam, M. Monck, D. Lee, O. Ludkovski, E.C. Leng, K. Clow, H. Stark, P. Scherrer, R.W. Graham and P.R. Cullis. Stabilized Plasmid-Lipid Particles for Systemic Gene Therapy. Gene Therapy 7, 1867-1874 (2000).

T. Chen, K.F. Wong, D. B. Fenske, L. R. Palmer and P.R. Cullis. Fluorescently Labelled Poly(ethylene glycol) Lipid Conjugates With Distal Cationic Headgroups. Bioconjugate Chemistry 11, 433-437 (2000).

C. Oja, P. Tardi, M.P. Redelmeier and P.R. Cullis. Doxorubicin Entrapped Within Liposome-Associated Antigens Results in a Selective Inhibition of the Antibody Response to the Linked Antigen. Biochim. Biophys. Acta 1468, 31-40 (2000).

I.M. Hafez, S. Ansell and P.R. Cullis. Tunable pH Sensitive Liposomes Composed of Mixtures of Cationic and Anionic Lipids. Biophys. J. 79, 1438-1446 (2000).

P.R. Cullis. “Liposomes by Accident” (A.D. Bangham award lecture). J. Liposome Res. 10, ix-xxiv (2000).

P. Scherrer, N. Maurer, M. Monck, E. Saravolac, Y.P. Zhang, J. Wheller, P. Tam, A. Lam and P. R. Cullis. Design and Properties of a Lipid-Based Carrier System for Systemic Gene Therapy. in Targeting of Drugs: Strategies for Gene Constructs and Delivery (G. Gregoriadis and B. McCormack, eds), NATO Science Series A: Life Sciences Vol. 323, p. 165-185, IOS Press, Ohmsha (2000).

S.M. Ansell, T.O. Harasym, P.G. Tardi, S.S. Buchkowsky, M.B. Bally and P.R. Cullis. Antibody Conjugation Methods for the Active Targeting of Liposomes. Methods in Molecular Medicine 25, 51-68 (2000).

S.C. Semple, S.K. Klimuk, T.O. Harasym, N. Dos Santos, S.M. Ansell, K.F. Wong, N. Maurer, H. Stark, P.R. Cullis, M.J. Hope, and P. Scherrer. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochim. Biophys. Acta 1510, 152-166 (2001).

D.B. Fenske, I. MacLachlan and P.R. Cullis. Long-Circulating Vectors for the Systemic Delivery of Genes. Current Opinion in Molecular Therapeutics 3, 153-158 (2001).

N. Maurer, K.F. Wong, H. Stark, L. Louie, D. McIntosh, T. Wong, P. Scherrer, S. Semple and P.R. Cullis. Spontaneous Entrapment of Polynucleotides Upon Electrostatic Interaction With Ethanol Destabilized Cationic Liposomes: Formation of Small Multilamellar Liposomes. Biophys. J. 80, 2310-2326 (2001).

D.B. Fenske, L.R. Palmer, T. Chen, K.F. Wong and P.R. Cullis. Cationic PEG Lipids Incorporated into Pre-Formed Vesicles Enhance Binding and Uptake into BHK Cells. Biochim. Biophys. Acta 78097, 1-14 (2001).

Hafez and P.R. Cullis. Roles of Lipid Polymorphism in Intracellular Delivery. Advanced Drug Delivery Reviews 47, 139-148 (2001).

Hafez, N. Maurer and P.R. Cullis. On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids. Gene Therapy 8, 1188-1196 (2001).

N. Maurer, D.B. Fenske and P.R. Cullis. Developments in Liposomal Drug Delivery Systems. Expert Opinion Biological Therapeutics 1, 1-33 (2001).

D.B. Fenske, I. MacLachlan and P.R. Cullis. Stabilized Plasmid-Lipid Particles: A Systemic Gene Therapy Vector. in Methods in Enzymology: Gene Therapy Methods (M. I. Phillips, ed.) 346, 36-71 (2002).

I.V. Zhigaltsev, K.F. Wong, N. Maurer and P.R. Cullis. Triggered Release of Doxorubicin Following Mixing of Cationic and Anionic Liposomes. Biochim. Biophys. Acta, 1565, 129-135 (2002).

P.R. Cullis. Stabilized plasmid-lipid particles for systemic gene therapy. Cell Mol Biol Lett. 2002;7(2):226.

J. Gaucheron, T. Wong, K.F. Wong, N. Maurer and P.R. Cullis. Synthesis and Properties of Novel Tetra- Alkyl Cationic Lipids. Bioconjugate Chemistry 13, 671-675 (2002).

L.R. Palmer, T. Chen, A.M.I. Lam, D.B. Fenske, K.F. Wong and P.R. Cullis. Transfection Properties of Stabilized Plasmid-Lipid Particles Containing Cationic PEG Lipids. Biochim. Biophys. Acta 1611, 204-216 (2003).

J. Finn, A. Lee, I. MacLachlan and P.R. Cullis. TAn Enhanced Autogene-based Dual Promoter Cytoplasmic Expression System Yields Increased Gene Expression In Vitro. Gene Therapy 11, 276-283 (2004).

T.M. Allen and P.R. Cullis. Drug Delivery Systems: Entering the Mainstream. Science 303, 1818-1822 (2004).

D.B. Fenske and P.R. Cullis. Liposomes: Models of Biological Membranes and Drug Delivery Systems. Physics in Canada 60, 187-194 (2004).

T. Chen, L. Palmer, D. B. Fenske, A. M. Lam, K. F. Wong and P. R. Cullis. Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake. J. Liposome Research 14, 155-173 (2004).

T. Chen, D. McIntosh, Y. He, J. Kim, D. A.Tirrell, P. Scherrer, D. B. Fenske, A. Sandhu and P. R. Cullis. Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pHdependent intracellular delivery of liposomal contents. Molecular Membrane Biology 21, 385-394 (2004).

I.M. Hafez and P.R. Cullis. Tunable pH-Sensitive Liposomes. Methods in Enzymology 387, 113-134 (2004).

D.B. Fenske and P.R. Cullis. Entrapment of Small Molecules and Nucleic Acid-Based Drugs in Liposomes. Methods in Enzymology 391, 7-39 (2005).

Methods in Enzymology 391, 40-57 (2005).

S.A. Abraham, D.N. Waterhouse, L.D. Mayer, P.R. Cullis, T.D. Madden and M.B. Bally. The Liposomal Formulation of Doxorubicin. Methods in Enzymology, 391, 71-96 (2005).

E. Ambegia, S. Ansell, P.R. Cullis, J. Heyes, L. Palmer and I. MacLachlan. Stabilized plasmid-lipid particles containing PEG-diacyglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochim. Biophys. Acta 1669, 155-163 (2005).

I.V.Zhigaltsev, N. Maurer, Q. Ahkong, R. Leone, E. Leng, J. Wang, S.C. Semple and P. R. Cullis. Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention. J. Controlled Release 104, 103-11.

J.D. Finn, T. Wong and P.R. Cullis. Investigation of factors responsible for cell line cytoplasmic expression differences. BMC Molecular Biology, 6, 1471-2199 (2005).

S.C. Semple, R. Leone, J. Wang, E.C. Leng, S.K. Klimuk, M.L. Eisenhardt, Z. Yuan, K. Edwards, N. Maurer, M.J. Hope, P.R. Cullis and Q. Ahkong. Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity. J. Pharmaceutical Science 94,1024 - 1038 (2005).

A.P. Sandhu, A.M.I. Lam, D.B. Fenske, L.R. Palmer, M. Johnston and P.R. Cullis. Calcium enhances the transfection potency of stabilized plasmid-lipid particles. Analytical Biochemistry, 341, 156-64 (2005).

MacLachlan and P.R. Cullis. Diffusible-PEG-lipid Stabilized Plasmid Lipid Particles. In: Huang L, Wagner E, eds. Non-viral Vectors. New York: Elsevier; 2005. p. 157-188.

J. Finn, I. MacLachlan and P.R. Cullis. Factors limiting autogene-based cytoplasmic expression systems. FASEB J. 19, 608-610 (2005).

I.V. Zhigaltsev, N. Maurer, K. Edwards, G. Karlsson and P.R. Cullis. Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention. J. Controlled Release 110 (2006) 378-386.

M.J.W. Johnston, S.C. Semple, S.K. Klimuk, K. Edwards, M.L. Eisenhardt, E.C. Leng, G. Karlsson, D. Yanko and P.R. Cullis. Therapeutically Optimized Rates of Drug Release can be Achieved by Varying the Drug-to-Lipid Ratio in Liposomal Vincristine Formulations. Biochim. Biophys. Acta 1758 (2006) 55-64.

D.B. Fenske and P.R. Cullis. Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques. Liposome Technology, Vol. 2 (G. Gregoriadis, ed.) p. 27-50 (2006).

N. Maurer, I. Zhigaltsev and P.R. Cullis. Encapsulation of Nucleic Acid-Based Therapeutics. Liposome Technology, Vol. 2 (G. Gregoriadis, ed.) p. 131-148 (2006).

S. de Jong, G.G. Chikh, L.L. Sekirov, S. Raney, S.C. Semple, S.K. Klimuk, Z.N. Yuan, M. Hope, P.R. Cullis and Y.K. Tam. Encapsulation of CpG ODN in Liposomal Nanoparticles Enhances the Immunostimulatory, Adjuvant and Anti-tumour Activity of Subcutaneously Administered CpG ODN. Cancer Immunology and Immunotherapy 56 (2007) 1251-1264.

M.J.W. Johnston, S.C. Semple, S.K. Klimuk, S. Ansell, N. Maurer , P.R. Cullis. Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochim. Biophys. Acta 1768, 1121-1127 (2007).

J. de Jonge, J.M. Leenhouts, M. Holtrop, P. Schoen, P. Scherrer, P.R. Cullis, J. Wilschut, A. Huckriede. Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA. Biochem J. 2007 Jul 1;405(1):41-9.

K. D. Wilson, S.G. Raney, L. Sekirov, G. Chikh, S. de Yong, P.R. Cullis and Y.K. Tam. Effects of i.v. and s.c. Administration on the Pharmacokinetics, Biodistribution, Cellular Uptake and Immunostimulatory Activity of CpG Oligonucleotides Encapsulated in Liposomal Nanoparticles. International Immunopharmacology 7, 1064-1075 (2007).

M.S. Webb, N.L. Boman, D. Masin, D. Yapp, E. Ramsay, G.N.C. Chiu, P.R. Cullis and M.B. Bally. A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity. Lett. Drug Design and Discovery 4, 426-433 (2007).

D.B. Fenske and P.R. Cullis. Liposomal Nanomedicines. Expert Opinion in Drug Delivery 5, 25-44 (2008).

D.B. Fenske, A. Chonn, P.R. Cullis. Liposomal nanomedicines: an emerging field. Toxicol Pathol. 2008 Jan;36(1):21-9.

Y. Sun, S. Cressman, N. Fang, P.R. Cullis, D. Chen. Capillary Electrophoresis Frontal Analysis for Characterization of avß3 Integrin Binding Interactions. Analytical Chem 80, 3105-3111 (2008).

S.G. Raney, K.D. Wilson, L. Sekirov, G. Chikh, S.D. de Jong, P.R. Cullis and Y.K. Tam. The effect of circulation lifetime and drug:lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG ODN. J. Drug Targeting16, 564-577 (2008).

M. J.W. Johnston, K. Edwards, G. Karlsson, and P.R. Cullis. Influence of Drug-to-Lipid Ratio on Drug Release Properties and Liposome Integrity in Liposomal Doxorubicin Formulations. J. Liposome Res. 18, 145-152 (2008).

K.D. Wilson, S.D. de Jong, M.Kazem, R. Lall, M.J. Hope, P.R. Cullis, Y.K. Tam. The Combination Of Stabilized Plasmid Lipid Particles And Lipid Nanoparticle Encapsulated CpG Containing Oligodeoxynucleotides As A Systemic Genetic Vaccine. J Gene Med 11, 14–25 (2009).

S. Cressman, Y. Sun, E.J. Maxwell, N. Fang, D.D.Y. Chen and P.R. Cullis. Binding and Uptake of RGDContaining Ligands to Cellular avß3 Integrins. Int. J. Peptide Research & Therapeutics 15:49–59 (2009).

G. Chikh, S.D. de Jong, L. Sekirov, S.G. Raney, P.R. Cullis, J.P. Dutz and Y.K. Tam. Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles. International Immunology 21, 757-67 (2009).

S. Cressman, I. Dobson, J.B. Lee., Y.Y.C. Tam, P.R. Cullis. Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. Bioconjugate Chemistry 20, 1404-1411 (2009).

I.V. Zhigaltsev, G. Winters, M. Srinivasulu, J. Crawford, M. Wong, L. Amankwa, D. Waterhouse, D. Masin, M. Webb, N. Harasym, L. Heller, M.B. Bally, M.A. Ciufolini, P.R. Cullis, N. Maurer. Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles. J. Control Release 144, 332-340 (2010).

S.C. Semple, A. Akinc, J. Chen, A.P. Sandhu, B.L. Mui, C.K. Cho, D.W. Sah, D. Stebbing, E.J. Crosley, E. Yaworski, I.M. Hafez, J.R. Dorkin, J. Qin, K. Lam, K.G. Rajeev, K.F. Wong, L.B. Jeffs, L. Nechev, M.L. Eisenhardt, M. Jayaraman, M. Kazem, M.A. Maier, M. Srinivasulu, M.J. Weinstein, Q. Chen, R. Alvarez, S.A. Barros, S. De, S.K. Klimuk, T. Borland, V. Kosovrasti, W.L. Cantley, Y.K. Tam, M. Manoharan, M.A. Ciufolini, M.A. Tracy, A. de Fougerolles, I. MacLachlan, P.R. Cullis, T.D. Madden, M.J. Hope. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6. Epub 2010 Jan 17.

S.D. de Jong, G. Basha, K.D. Wilson, M. Kazem, W. Jefferies, P.R. Cullis and Y.K. Tam. The immunostimulatory activity of unmethylated and methylated CpG ODN is dependent on their ability to colocalize with TLR9 in late endosomes. J. Immunology, 184, 6092-6102 (2010).

J.B. Lee, K. Zhang, Y.Y. Tam, Y.K. Tam, N.M. Belliveau, V.Y. Sung, P.J. Lin, E. Leblanc, M.A. Ciufolini, P.S. Rennie, P.R. Cullis. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. Int J Cancer. 2012 Sep 1;131(5):E781-90. doi: 10.1002/ijc.27361. Epub 2012 Jan 3.

G. Basha, T. I. Novobrantseva, N. Rosin, Y.Y.C. Tam, I. M. Hafez, M. K. Wong, T. Sugo, V. M. Ruda, J. Qin, B. Klebanov, M. Ciufolini, A. Akinc, Y. K. Tam, M. J. Hope and P. R. Cullis. Influence Of Cationic Lipid Composition On Gene Silencing Properties Of Lipid Nanoparticle Formulations Of siRNA In Antigen Presenting Cells. Molecular Therapy,19(12):2186-200 (2011).

P. Geetha-Loganathan, S. Nimmagadda, I. Hafez, K. Fu, P.R. Cullis, J.M. Richman. Development of high-concentration lipoplexes for in vivo gene function studies in vertebrate embryos. Dev Dyn. 2011 Sep;240(9):2108-19. doi: 10.1002/dvdy.22708. Epub 2011 Jul 29.

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids. 2012 Jan 24;1:e4. doi: 10.1038/mtna.2011.3.

Y.Y.C.Tam, S. Chen, J. Zaifman, Y.K. Tam, P.J. Lin, S. Ansell, M. Roberge, M. Ciufolini, and P. R. Cullis. Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine. 2012 Dec 6. pii: S1549-9634(12)00689-2. doi: 10.1016/j.nano.2012.11.006. [Epub ahead of print].

I.V. Zhigaltsev, N. Belliveau, I. Hafez, J. Huft, C.L. Hansen and P.R. Cullis. Bottom-up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores using Millisecond Microfluidic Mixing. Langmuir, 28(7):3633-40 (2012).

P.J.C Lin, Y.Y.C. Tam, I. Hafez, A. Sandhu, S. Chen, M. Ciufolini, R. Nabi, and P.R. Cullis. Influence Of Cationic Lipid Composition On Uptake And Intracellular Processing Of Lipid Nanoparticle Formulations Of siRNA In A Macrophage Cell Line. Nanomedicine, Epub ahead of print (2012).

N.M. Belliveau, J. Huft, P.J.C Lin, S. Chen, J. Lee, Y.K. Tam, C Hansen and P.R. Cullis. Microfluidic Synthesis of Highly Potent Limit-Size Lipid Nanoparticles for In Vivo Delivery of siRNA. Molecular Therapy-Nucleic Acids, Molecular Therapy–Nucleic Acids (2012) 1, e37.

A.K. Leung, I.M. Hafez, S. Baoukina, N.M. Belliveau, I. Zhigaltsev, E. Afshinmanesh, D.P. Tieleman, C.L. Hansen, M.J. Hope and P.R. Cullis. Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core. J. Phys. Chem. C 34, 18440-18450 (2012).

M. Jayaraman, S.M. Ansell, B.L. Mui, Y.K. Tam, J. Chen, X. Du, D. Butler, L. Eltepu, S. Matsuda, J.K. Narayanannair, K.G. Rajeev, I.M. Hafez, A. Akinc, M.A. Maier, M.A. Tracy, P.R. Cullis, T.D. Madden, M. Manoharan, M.J. Hope. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo. Angew Chem Int Ed Engl,Epub ahead of print (2012).

T.M.Allen and P.R. Cullis. Liposomal drug delivery systems: From concept to clinical applications. Advance Drug Delivery Reviews. Volume 65, Issue 1, Pages 1-148 (January 2013).

MA Maier, M Jayaraman, S Matsuda, J Liu, S Barros,W Querbes, YK Tam, SM Ansell, V Kumar, J Qin, X Zhang, Q Wang, S Panesar, R Hutabarat, M Carioto, J Hettinger, P Kandasamy, D Butler, KG Rajeev, B Pang, K Charisse, K Fitzgerald, BL Mui, X Du, P Cullis, TD Madden, MJ Hope, M Manoharan, A Akinc. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics. Mol Ther. 2013 Aug;21(8):1570-8. doi: 10.1038/mt.2013.124. Epub 2013 Jun 25.

YYC Tam, S Chen, PR Cullis. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013; 5(3):498-507.

C. Wan, T.M. Allen and P.R. Cullis. Lipid nanoparticle delivery systems for siRNA-based therapeutics. Drug Delivery and Translational Research. 2013; doi:10.1007/s13346-013-0161-z

B.L. Mui, Y.K. Tam, M. Jayaraman, S.M. Ansell, X. Du, Y.Y.C. Tam, P.J.C. Lin, S. Chen, J.K. Narayanannair, K.G. Rajeev, M. Manoharan, A. Akinc, M.A. Maier, P. Cullis, T.D. Madden, M.J. Hope. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy—Nucleic Acids (2013) 2, e139; doi:10.1038/mtna.2013.66

R.L. Rungta, H.B. Choi, P.J.C. Lin, R. Ko, D. Ashby, J. Nair, M. Manoharan, P.R. Cullis, B.A. MacVicar. Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Mol Ther Nucleic Acids. 2013 Dec 3;2:e136. doi: 10.1038/mtna.2013.65

U.H. Neumann, S. Chen, Y.Y.C. Tam, R.K. Baker, S.D. Covey, P.R. Cullis, and T.J. Kieffer. IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice. Endocrinology, 155(3):716-25 (2014)

C. Walsh, K. Ou, N.M. Belliveau, T.J. Leaver, A.W. Wild, J. Huft, P.J.C Lin, S. Chen, A.K. Leung, J.B. Lee, C.L. Hansen, R.J. Taylor, E.C. Ramsay, and P.R. Cullis. Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications. Methods Mol Biol. 2014;1141:109-20. doi: 10.1007/978-1-4939-0363-4_6

S. Chen, Y.Y.C. Tam, P.J.C. Lin, A.K.K. Leung, Y.K. Tam, P.R. Cullis. Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. J. Controlled Release 196 (2014) 106–112.

A.K.K. Leung, Y.Y.C. Tam, P.R. Cullis. Lipid Nanoparticles for Short Interfering RNA Delivery. Chapter Four-Advances in Genetics, Volume 88 ISSN 0065-2660.

R.L. Rungta, H.B. Choi, J.R. Tyson, A. Malik, L. Dissing-Olesen, P.J.C. Lin, S.M. Cain, P.R. Cullis, T.P. Snutch, B.A. MacVicar. The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema. Cell 161, 610–621, April 23, 2015.

I.V. Zhigaltsev, Y.K. Tam, A.K.K. Leung, P.R. Cullis. Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents. J. Liposome Research, Early Online: 1–7; DOI: 10.3109/08982104.2015.1025411.

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