LN Delivery of Conventional Drugs
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The aim of our research with respect to the encapsulation of conventional chemotherapeutics is to take advantage of the natural tendency of long-circulating LN systems to accumulate at tumour sites.
Our research in this area focuses on designing LN delivery systems which have optimized circulation lifetimes, to allow for an increased concentration of drug at the tumour site, and optimized drug release characteristics, to maximize the benefits of providing local sustained release of cell cycle-specific drugs at the site of disease. In addition, we are investigating ways in which to extend the LN technology to drugs that currently are not amenable to loading and retention in LN systems in attempt to increase the therapeutic index of already established drugs. |
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