NanoMedicines Research Group

Login Form

All Publications

Sorted in chronological order and then in alphabetical order, shown in reverse order.

Last Updated: November 2024

#	Citation	PDF
415	Zhao, B., Kamanzi, A., Zhang, Y., Chan, K. Y. T., Robertson, M., Leslie, S., & Cullis, P. R. (2024). Determination of the interior pH of lipid nanoparticles using a pH-sensitive fluorescent dye-based DNA probe. Biosensors and Bioelectronics, 251, 116065. doi:10.1016/j.bios.2024.116065
414	Tafech, B., Rokhforouz, M.-R., Leung, J., Sung, M. M. H., Lin, P. J. C., Sin, D. D., Lauster, D., Block, S., Quon, B. S., Tam, Y., Cullis, P. R., Feng, J. J., & Hedtrich, S. (2024). Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions. Advanced Healthcare Materials, 2304525. doi:10.1002/adhm.202304525
413	Strong, C., Leung, J., Kang, E., Badior, K. E., Robertson, M., Pereyra, N., Rowe, E., Wietrzny, A., Ma, B., Noronha, Z., Arnold, D., Ciufolini, M. A., Devine, D. V., Jan, E., Cullis, P. R., & Kastrup, C. J. (2024). Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices. Blood. doi:10.1182/blood.2024024405
412	Strilchuk, A. W., Hur, W. S., Batty, P., Sang, Y., Abrahams, S. R., Yong, A. S. M., Leung, J., Silva, L. M., Schroeder, J. A., Nesbitt, K., de Laat, B., Moutsopoulos, N. M., Bugge, T. H., Shi, Q., Cullis, P. R., Merricks, E. P., Wolberg, A. S., Flick, M. J., Lillicrap, D., Nichols, T. C., & Kastrup, C. J. (2024). Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A. Science Translational Medicine, 16(735), eadh0027. doi:10.1126/scitranslmed.adh0027
411	Short, L., Holt, R. A., Cullis, P. R., & Evgin, L. (2024). Direct in vivo CAR T cell engineering. Trends in Pharmacological Sciences, 45(5), 406-418. doi:10.1016/j.tips.2024.03.004
410	Leung, J., Primbetova, A., Strong, C., Hay, B. N., Hsu, H. H., Hagner, A., Foster, L. J., Devine, D., Cullis, P. R., Zandstra, P. W., & Kastrup, C. J. (2024). Genetic engineering of megakaryocytes from blood progenitor cells using messenger RNA lipid nanoparticles. Journal of Thrombosis and Haemostasis. doi:10.1016/j.jtha.2024.09.008
409	Kamanzi, A., Zhang, Y., Gu, Y. F., Liu, F., Berti, R., Wang, B., Saadati, F., Ciufolini, M. A., Kulkarni, J., Cullis, P., & Leslie, S. (2024). Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters. ACS Nano, 18(28), 18191-18201. doi:10.1021/acsnano.3c12981
408	Francia, V., Zhang, Y., Cheng, M. H. Y., Schiffelers, R. M., Witzigmann, D., & Cullis, P. R. (2024). A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles. Proceedings of the National Academy of Sciences, 121(11), e2307803120. doi:10.1073/pnas.2307803120
407	Ferraresso, F., Badior, K., Seadler, M., Zhang, Y., Wietrzny, A., Cau, M. F., Haugen, A., Rodriguez, G. G., Dyer, M. R., Cullis, P. R., Jan, E., & Kastrup, C. J. (2024). Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine. Molecular Therapy - Methods & Clinical Development, 101314. doi:10.1016/j.omtm.2024.101314
406	Cullis, P. R., & Felgner, P. L. (2024). The 60-year evolution of lipid nanoparticles for nucleic acid delivery. Nature Reviews Drug Discovery. doi:10.1038/s41573-024-00977-6
405	Cau, M. F., Ferraresso, F., Seadler, M., Badior, K., Zhang, Y., Ketelboeter, L. M., Rodriguez, G. G., Chen, T., Ferraresso, M., Wietrzny, A., Robertson, M., Haugen, A., Cullis, P. R., de Moya, M., Dyer, M., & Kastrup, C. J. (2024). siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles. Molecular Therapy Methods & Clinical Development, 32(2). doi:10.1016/j.omtm.2024.101258
404	Anwar, M. A., Keshteli, A. H., H., Y., Wang, W., Li, X., Messier, H. M., Cullis, P. R., Borchers, C. H., Fraser, R., & Wishart, D. S. (2024). Blood-Based Multiomics-Guided Detection of a Precancerous Pancreatic Tumor. OMICS: A Journal of Integrative Biology, 28(4), 182-192. doi:omi.2023.0278
403	Zhigaltsev, I. V., & Cullis, P. R. (2023). Morphological Behavior of Liposomes and Lipid Nanoparticles. Langmuir, 39(9), 3185-3193. doi:10.1021/acs.langmuir.2c02794
402	Uzel, A., Agiotis, L., Baron, A., Zhigaltsev, I. V., Cullis, P. R., Hasanzadeh Kafshgari, M., & Meunier, M. (2023). Single Pulse Nanosecond Laser-Stimulated Targeted Delivery of Anti-Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles. Small, 19(52), 2305591. doi:10.1002/smll.202305591
401	Mo, Y., Cheng, M. H. Y., D’Elia, A., Doran, K., Ding, L., Chen, J., Cullis, P. R., & Zheng, G. (2023). Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles. ACS Nano, 17(5), 4688-4703. doi:10.1021/acsnano.2c10936
400	Meulewaeter, S., Zhang, Y., Wadhwa, A., Fox, K., Lentacker, I., Harder, K. W., Cullis, P. R., De Smedt, S. C., H. Y. Cheng, M., & Verbeke, R. (2023). Considerations on the design of lipid-based mRNA vaccines against cancer. Journal of Molecular Biology, 168385. doi:10.1016/j.jmb.2023.168385
399	Meulewaeter, S., Nuytten, G., Cheng, M. H. Y., De Smedt, S. C., Cullis, P. R., De Beer, T., Lentacker, I., & Verbeke, R. (2023). Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures. Journal of Controlled Release, 357, 149-160. doi:10.1016/j.jconrel.2023.03.039
398	Leung, J., Strong, C., Badior, K. E., Robertson, M. K., Wu, X., Meledeo, M. A., Kang, E., Paul, M., Sato, Y., Harashima, H., Cap, A. P., Devine, D. V., Jan, E., Cullis, P. R., & Kastrup, C. J. (2023). Genetically engineered transfusable platelets using mRNA lipid nanoparticles. Science Advances, 9(48), eadi0508. doi:10.1126/sciadv.adi0508
397	Cheng, M. H. Y., Leung, J., Zhang, Y., Strong, C., Basha, G., Momeni, A., Chen, Y., Jan, E., Abdolahzadeh, A., Wang, X., Kulkarni, J. A., Witzigmann, D., & Cullis, P. R. (2023). Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency. Advanced Materials, 35(31), 2303370. doi:10.1002/adma.202303370
396	Chander, N., Basha, G., Cheng, M. H. Y., Witzigmann, D., & Cullis, P. R. (2023). Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues. Molecular Therapy - Methods & Clinical Development, 30, 235-245. doi:10.1016/j.omtm.2023.06.005
395	Bolsoni, J., Liu, D., Mohabatpour, F., Ebner, R., Sadhnani, G., Tafech, B., Leung, J., Shanta, S., An, K., Morin, T., Chen, Y., Arguello, A., Choate, K., Jan, E., Ross, C. J. D., Brambilla, D., Witzigmann, D., Kulkarni, J., Cullis, P. R., & Hedtrich, S. (2023). Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano, 17(21), 22046-22059. doi:10.1021/acsnano.3c08644
394	Zhigaltsev, I. V., Tam, Y. Y. C., Kulkarni, J. A., & Cullis, P. R. (2022). Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug. Langmuir, 38(25), 7858-7866. doi:10.1021/acs.langmuir.2c01221
393	Tam, A., Kulkarni, J., An, K., Li, L., Dorscheid, D. R., Singhera, G. K., Bernatchez, P., Reid, G. S. D., Chan, K. Y. T., Witzigmann, D., Cullis, P. R., Sin, D. D., & Lim, C. J. (2022). Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways. European Journal of Pharmaceutical Sciences, 176, 106234. doi:10.1016/j.ejps.2022.106234
392	Quick, J., Dos Santos, N., Cheng, M. H. Y., Chander, N., Brimacombe, C. A., Kulkarni, J. A., van der Meel, R., Tam, Y. Y. C., Witzigmann, D., & Cullis, P. R. (2022). Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy. Journal of Controlled Release, 349, 174-183. doi:10.1016/j.jconrel.2022.06.051
391	Pattipeiluhu, R., Arias-Alpizar, G., Basha, G., Chan, K. Y. T., Bussmann, J., Sharp, T. H., Moradi, M.-A., Sommerdijk, N., Harris, E. N., Cullis, P. R., Kros, A., Witzigmann, D., & Campbell, F. (2022). Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System. Advanced Materials, 34(16), 2201095. doi:10.1002/adma.202201095
390	Labouta, H. I., Langer, R., Cullis, P. R., Merkel, O. M., Prausnitz, M. R., Gomaa, Y., Nogueira, S. S., & Kumeria, T. (2022). Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective. Drug delivery and translational research. doi:10.1007/s13346-022-01146-1
389	Juang, L. J., Hur, W. S., Silva, L. M., Strilchuk, A. W., Francisco, B., Leung, J., Robertson, M. K., Groeneveld, D. J., La Prairie, B., Chun, E. M., Cap, A. P., Luyendyk, J. P., Palumbo, J. S., Cullis, P. R., Bugge, T. H., Flick, M. J., & Kastrup, C. J. (2022). Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA. Blood, 139(9), 1302-1311. doi:10.1182/blood.2021014559
388	Cullis, P. R. (2022). Learning lessons from lipids to make COVID-19 vaccines. Cell, 185(8), 1279-1282. doi:10.1016/j.cell.2022.03.026
387	Cheng, M. H. Y., Brimacombe, C. A., Verbeke, R., & Cullis, P. R. (2022). Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies. Molecular Pharmaceutics, 19(6), 1663-1668. doi:10.1021/acs.molpharmaceut.2c00365
386	Basha, G., Cottle, A. G., Pretheeban, T., Chan, K. Y. T., Witzigmann, D., Young, R. N., Rossi, F. M. V., & Cullis, P. R. (2022). Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo. Molecular Therapy. doi:10.1016/j.ymthe.2022.06.012
395	An, K., Kurek, D., Mahadeo, M., Zhang, Y., Thewalt, J. L., Cullis, P. R., & Kulkarni, J. A. (2022). On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology. Langmuir, 38(46), 14036-14043. doi:10.1021/acs.langmuir.2c01492
384	Al Fayez, N., Rouhollahi, E., Ong, C. Y., Wu, J., Nguyen, A., Böttger, R., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2022). Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen. Journal of Controlled Release, 350, 630-641. doi:10.1016/j.jconrel.2022.08.058
383	Al Fayez, N., Böttger, R., Ghosh, S., Nakajima, Y., Chao, P.-H., Rouhollahi, E., Nguyen, A., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2022). Development of a child-friendly oral drug formulation using liposomal multilamellar vesicle technology. International Journal of Pharmaceutics, 625, 122107. doi:10.1016/j.ijpharm.2022.122107
382	Vogler, J., Böttger, R., Al Fayez, N., Zhang, W., Qin, Z., Hohenwarter, L., Chao, P.-H., Rouhollahi, E., Bilal, N., Chen, N., Lee, B., Chen, C., Wilkinson, B., Kieffer, T. J., Kulkarni, J. A., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2021). Altering the intra-liver distribution of phospholipid-free small unilamellar vesicles using temperature-dependent size-tunability. Journal of Controlled Release, 333, 151-161. doi:10.1016/j.jconrel.2021.03.025
381	van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R., & Tam, Y. Y. C. (2021). Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery. Small, 17(37), 2103025. doi:10.1002/smll.202103025
380	Terada, T., Kulkarni, J. A., Huynh, A., Tam, Y. Y. C., & Cullis, P. (2021). Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis. Biological and Pharmaceutical Bulletin, 44(1), 144-149. doi:10.1248/bpb.b20-00679
379	Terada, T., Kulkarni, J. A., Huynh, A., Chen, S., van der Meel, R., Tam, Y. Y. C., & Cullis, P. R. (2021). Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach. Langmuir, 37(3), 1120-1128. doi:10.1021/acs.langmuir.0c03039
378	Tam, A., Leclair, P., Li, L. V., Yang, C. X., Li, X., Witzigmann, D., Kulkarni, J. A., Hackett, T. L., Dorscheid, D. R., Singhera, G. K., Hogg, J. C., Cullis, P. R., Sin, D. D., & Lim, C. J. (2021). FAM13A as potential therapeutic target in modulating TGF-beta-induced airway tissue remodeling in COPD. American Journal of Physiology-Lung Cellular and Molecular Physiology. doi:10.1152/ajplung.00477.2020
377	Morozko, E. L., Smith-Geater, C., Monteys, A. M., Pradhan, S., Lim, R. G., Langfelder, P., Kachemov, M., Hill, A., Stocksdale, J. T., Cullis, P. R., Wu, J., Ochaba, J., Miramontes, R., Chakraborty, A., Hazra, T. K., Lau, A., St-cyr, S., Orellana, I., Kopan, L., Wang, K. Q., Yeung, S., Leavitt, B. R., Reidling, J. C., Yang, X. W., Steffan, J. S., Davidson, B. L., Sarkar, P. S., & Thompson, L. M. (2021). PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease. Proceedings of the National Academy of Sciences, 118(4), e2021836118. doi:10.1073/pnas.2021836118
376	Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R., & van der Meel, R. (2021). The current landscape of nucleic acid therapeutics. Nature Nanotechnology. doi:10.1038/s41565-021-00898-0
375	Kulkarni, J. A., Chen, S., & Tam, Y. Y. C. (2021). Scalable Production of Lipid Nanoparticles Containing Amphotericin B. Langmuir, 37(24), 7312-7319. doi:10.1021/acs.langmuir.1c00530
374	Kamanzi, A., Gu, Y. F., Tahvildari, R., Friedenberger, Z., Zhu, X. Q., Berti, R., Kurylowicz, M., Witzigmann, D., Kulkarni, J. A., Leung, J., Andersson, J., Dahlin, A., Höök, F., Sutton, M., Cullis, P. R., & Leslie, S. (2021). Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles. ACS Nano. doi:10.1021/acsnano.1c04862
373	Henrickson, A., Kulkarni, J. A., Zaifman, J., Gorbet, G. E., Cullis, P. R., & Demeler, B. (2021). Density Matching Multi-wavelength Analytical Ultracentrifugation to Measure Drug Loading of Lipid Nanoparticle Formulations. ACS Nano. doi:10.1021/acsnano.0c10069
372	Chander, N., Morstein, J., Bolten, J. S., Shemet, A., Cullis, P. R., Trauner, D., & Witzigmann, D. (2021). Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release. Small, 2008198. doi:10.1002/smll.202008198
371	Al Fayez, N., Böttger, R., Rouhollahi, E., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2021). Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity. Molecular Pharmaceutics. doi:10.1021/acs.molpharmaceut.1c00520
370	Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020). Lipid nanoparticle technology for therapeutic gene regulation in the liver. Advanced Drug Delivery Reviews, 159, 344-363. doi:10.1016/j.addr.2020.06.026
369	van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R., & Tam, Y. Y. C. (2020). Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery. bioRxiv, 2020.2001.2016.907394. doi:10.1101/2020.01.16.907394
368	Uhl, P., Grundmann, C., Sauter, M., Storck, P., Tursch, A., Özbek, S., Leotta, K., Roth, R., Witzigmann, D., Kulkarni, J. A., Fidelj, V., Kleist, C., Cullis, P. R., Fricker, G., & Mier, W. (2020). Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide. Nanomedicine: Nanotechnology, Biology and Medicine, 24, 102132. doi:10.1016/j.nano.2019.102132
367	Strilchuk, A. W., Meixner, S. C., Leung, J., Safikhan, N. S., Kulkarni, J. A., Russell, H. M., van der Meel, R., Sutherland, M. R., Owens III, A. P., Palumbo, J. S., Conway, E. M., Pryzdial, E. L. G., Cullis, P. R., & Kastrup, C. J. (2020). Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. Blood, 136(25), 2946-2954. doi:10.1182/blood.2020004976
366	Roberts, M. E., Barvalia, M., Silva, J. A. F. D., Cederberg, R. A., Chu, W., Wong, A., Tai, D. C., Chen, S., Matos, I., Priatel, J. J., Cullis, P. R., & Harder, K. W. (2020). Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan. Circulation Research, 126(10), e61-e79. doi:10.1161/CIRCRESAHA.119.315708
365	Ramezanpour, M., Schmidt, M. L., Bashe, B. Y. M., Pruim, J. R., Link, M. L., Cullis, P. R., Harper, P. E., Thewalt, J. L., & Tieleman, D. P. (2020). Structural Properties of Inverted Hexagonal Phase: A Hybrid Computational and Experimental Approach. Langmuir, 36(24), 6668-6680. doi:10.1021/acs.langmuir.0c00600
364	Kulkarni, J. A., Thomson, S. B., Zaifman, J., Leung, J., Wagner, P. K., Hill, A., Tam, Y. Y. C., Cullis, P. R., Petkau, T. L., & Leavitt, B. R. (2020). Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles. Nanoscale, 12(47), 23959-23966. doi:10.1039/D0NR06816K
363	Francia, V., Schiffelers, R. M., Cullis, P. R., & Witzigmann, D. (2020). The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy. Bioconjugate Chemistry, 31(9), 2046-2059. doi:10.1021/acs.bioconjchem.0c00366
362	Chen, K. T. J., Anantha, M., Leung, A. W. Y., Kulkarni, J. A., Militao, G. G. C., Wehbe, M., Sutherland, B., Cullis, P. R., & Bally, M. B. (2020). Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use. Drug delivery and translational research, 10(1), 202-215. doi:10.1007/s13346-019-00674-7
361	Anwar, M. A., Barrera-Machuca, A. A., Calderon, N., Wang, W., Tausan, D., Vayali, T., Wishart, D., Cullis, P. R., & Fraser, R. (2020). Value-based healthcare delivery through metabolomics-based personalized health platform. Healthcare Management Forum, 33(3), 126-134. doi:10.1177/0840470420904733
360	Zhang, W., Böttger, R., Qin, Z., Kulkarni, J. A., Vogler, J., Cullis, P. R., & Li, S.-D. (2019). Phospholipid-Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver. Small, 15(43), 1901782. doi:10.1002/smll.201901782
359	Ramezanpour, M., Schmidt, M. L., Bodnariuc, I., Kulkarni, J. A., Leung, S. S. W., Cullis, P. R., Thewalt, J. L., & Tieleman, D. P. (2019). Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function. Nanoscale, 11(30), 14141-14146. doi:10.1039/c9nr02297j
358	Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thony, B., Tam, Y. Y. C., & Cullis, P. R. (2019). Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads. Nanoscale, 11(18), 9023-9031. doi:10.1039/c9nr02004g
357	Kulkarni, J. A., Witzigmann, D., Leung, J., Tam, Y. Y. C., & Cullis, P. R. (2019). On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale, 11(45), 21733-21739. doi:10.1039/c9nr09347h
356	Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R., & van der Meel, R. (2019). Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics. Accounts of Chemical Research, 52(9), 2435-2444. doi:10.1021/acs.accounts.9b00368
355	Jyotsana, N., Sharma, A., Chaturvedi, A., Budida, R., Scherr, M., Kuchenbauer, F., Lindner, R., Noyan, F., Suhs, K. W., Stangel, M., Grote-Koska, D., Brand, K., Vornlocher, H. P., Eder, M., Thol, F., Ganser, A., Humphries, R. K., Ramsay, E., Cullis, P., & Heuser, M. (2019). Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo. Annals of Hematology, 98(8), 1905-1918. doi:10.1007/s00277-019-03713-y
354	Hamano, N., Bottger, R., Lee, S. E., Yang, Y., Kulkarni, J. A., Ip, S., Cullis, P. R., & Li, S. D. (2019). Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin. Molecular Pharmaceutics, 16(9), 3957-3967. doi:10.1021/acs.molpharmaceut.9b00583
353	Buck, J., Grossen, P., Cullis, P. R., Huwyler, J., & Witzigmann, D. (2019). Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery. ACS Nano, 13(4), 3754-3782. doi:10.1021/acsnano.8b07858
352	Bromma, K., Rieck, K., Kulkarni, J., O’Sullivan, C., Sung, W., Cullis, P., Schuemann, J., & Chithrani, D. B. (2019). Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy. Cancer Nanotechnology, 10(1), 1. doi:10.1186/s12645-019-0046-z
351	Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., Mui, B. L., Semple, S. C., Tam, Y. K., Ciufolini, M., Witzigmann, D., Kulkarni, J. A., van der Meel, R., & Cullis, P. R. (2019). The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nature Nanotechnology, 14(12), 1084-1087. doi:10.1038/s41565-019-0591-y
350	Tang, W. L., Tang, W. H., Szeitz, A., Kulkarni, J., Cullis, P., & Li, S. D. (2018). Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials, 166, 13-26. doi:10.1016/j.biomaterials.2018.03.004
349	Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., van der Meel, R., Thewalt, J. L., Tam, Y. Y. C., & Cullis, P. R. (2018). On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA. ACS Nano, 12(5), 4787-4795. doi:10.1021/acsnano.8b01516
348	Kulkarni, J. A., Cullis, P. R., & van der Meel, R. (2018). Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility. Nucleic Acid Therapeutics, 28(3), 146-157. doi:10.1089/nat.2018.0721
347	Jyotsana, N., Sharma, A., Chaturvedi, A., Scherr, M., Kuchenbauer, F., Sajti, L., Barchanski, A., Lindner, R., Noyan, F., Suhs, K. W., Grote-Koska, D., Brand, K., Vornlocher, H. P., Stanulla, M., Bornhauser, B., Bourquin, J. P., Eder, M., Thol, F., Ganser, A., Humphries, R. K., Ramsay, E., Cullis, P., & Heuser, M. (2018). RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia, 32(1), 224-226. doi:10.1038/leu.2017.269
346	Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018). State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery. Small Methods, 2(9), 1700375. doi:10.1002/smtd.201700375
345	Chen, S., Zaifman, J., Kulkarni, J. A., Zhigaltsev, I. V., Tam, Y. K., Ciufolini, M. A., Tam, Y. Y. C., & Cullis, P. R. (2018). Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids. Journal of Controlled Release, 286, 46-54. doi:10.1016/j.jconrel.2018.07.026
344	Cain, S. M., Tyson, J. R., Choi, H. B., Ko, R., Lin, P. J. C., LeDue, J. M., Powell, K. L., Bernier, L. P., Rungta, R. L., Yang, Y., Cullis, P. R., O'Brien, T. J., MacVicar, B. A., & Snutch, T. P. (2018). CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons. Epilepsia, 59(4), 778-791. doi:10.1111/epi.14018
343	Neumann, U. H., Ho, J. S. S., Chen, S., Tam, Y. Y. C., Cullis, P. R., & Kieffer, T. J. (2017). Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Molecular Metabolism, 6(10), 1161-1172. doi:10.1016/j.molmet.2017.06.012
342	Kulkarni, J. A., Tam, Y. Y. C., Chen, S., Tam, Y. K., Zaifman, J., Cullis, P. R., & Biswas, S. (2017). Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles. Nanoscale, 9(36), 13600-13609. doi:10.1039/c7nr03272b
341	Kulkarni, J. A., Myhre, J. L., Chen, S., Tam, Y. Y. C., Danescu, A., Richman, J. M., & Cullis, P. R. (2017). Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine, 13(4), 1377-1387. doi:10.1016/j.nano.2016.12.014
340	Cullis, P. R., & Hope, M. J. (2017). Lipid Nanoparticle Systems for Enabling Gene Therapies. Molecular Therapy, 25(7), 1467-1475. doi:10.1016/j.ymthe.2017.03.013
339	Zhigaltsev, I. V., Tam, Y. K., Leung, A. K., & Cullis, P. R. (2016). Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents. Journal of Liposome Research, 26(2), 96-102. doi:10.3109/08982104.2015.1025411
338	Wang, H., Tam, Y. Y., Chen, S., Zaifman, J., van der Meel, R., Ciufolini, M. A., & Cullis, P. R. (2016). The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA. Molecular Therapy, 24(12), 2100-2108. doi:10.1038/mt.2016.179
337	Lee, J. B., Zhang, K., Tam, Y. Y., Quick, J., Tam, Y. K., Lin, P. J., Chen, S., Liu, Y., Nair, J. K., Zlatev, I., Rajeev, K. G., Manoharan, M., Rennie, P. S., & Cullis, P. R. (2016). A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo. Molecular Therapy: Nucleic Acids, 5, e348. doi:10.1038/mtna.2016.43
336	Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016). Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA. Journal of Controlled Release, 235, 236-244. doi:10.1016/j.jconrel.2016.05.059
335	Basha, G., Ordobadi, M., Scott, W. R., Cottle, A., Liu, Y., Wang, H., & Cullis, P. R. (2016). Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo. Molecular Therapy: Nucleic Acids, 5(9), e363. doi:10.1038/mtna.2016.68
334	Yamamoto, Y., Lin, P. J., Beraldi, E., Zhang, F., Kawai, Y., Leong, J., Katsumi, H., Fazli, L., Fraser, R., Cullis, P. R., & Gleave, M. (2015). siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer. Clinical Cancer Research, 21(21), 4845-4855. doi:10.1158/1078-0432.Ccr-15-0866
333	Rungta, R. L., Choi, H. B., Tyson, J. R., Malik, A., Dissing-Olesen, L., Lin, P. J. C., Cain, S. M., Cullis, P. R., Snutch, T. P., & MacVicar, B. A. (2015). The cellular mechanisms of neuronal swelling underlying cytotoxic edema. Cell, 161(3), 610-621. doi:10.1016/j.cell.2015.03.029
332	Ramishetti, S., Kedmi, R., Goldsmith, M., Leonard, F., Sprague, A. G., Godin, B., Gozin, M., Cullis, P. R., Dykxhoorn, D. M., & Peer, D. (2015). Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles. ACS Nano, 9(7), 6706-6716. doi:10.1021/acsnano.5b02796
331	Leung, A. K., Tam, Y. Y., Chen, S., Hafez, I. M., & Cullis, P. R. (2015). Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems. Journal of Physical Chemistry B, 119(28), 8698-8706. doi:10.1021/acs.jpcb.5b02891
330	Wan, C., Allen, T. M., & Cullis, P. R. (2014). Lipid nanoparticle delivery systems for siRNA-based therapeutics. Drug delivery and translational research, 4(1), 74-83. doi:10.1007/s13346-013-0161-z
329	Walsh, C., Ou, K., Belliveau, N. M., Leaver, T. J., Wild, A. W., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Lee, J. B., Hansen, C. L., Taylor, R. J., Ramsay, E. C., & Cullis, P. R. (2014). Microfluidic-based manufacture of siRNA-lipid nanoparticles for therapeutic applications. Methods in Molecular Biology, 1141, 109-120. doi:10.1007/978-1-4939-0363-4_6
328	Neumann, U. H., Chen, S., Tam, Y. Y., Baker, R. K., Covey, S. D., Cullis, P. R., & Kieffer, T. J. (2014). IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology, 155(3), 716-725. doi:10.1210/en.2013-1622
327	Lin, P. J., Tam, Y. K., & Cullis, P. R. (2014). Development and clinical applications of siRNA-encapsulated lipid nanoparticles in cancer. Clinical Lipidology, 9(3), 317-331. doi:10.2217/clp.14.27
326	Leung, A. K., Tam, Y. Y., & Cullis, P. R. (2014). Lipid nanoparticles for short interfering RNA delivery. Advances in Genetics, 88, 71-110. doi:10.1016/b978-0-12-800148-6.00004-3
325	Fenske, D. B., & Cullis, P. R. (2014). Chapter 15 - Medical Applications of Lipid Nanoparticles. In Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application (1 ed.). Boca Raton: CRC Press.
324	Chen, S., Tam, Y. Y., Lin, P. J., Leung, A. K., Tam, Y. K., & Cullis, P. R. (2014). Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. Journal of Controlled Release, 196, 106-112. doi:10.1016/j.jconrel.2014.09.025
323	Tam, Y. Y. C., Chen, S., & Cullis, P. R. (2013). Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics, 5(3), 498-507. doi:10.3390/pharmaceutics5030498
322	Tam, Y. Y., Chen, S., Zaifman, J., Tam, Y. K., Lin, P. J., Ansell, S., Roberge, M., Ciufolini, M. A., & Cullis, P. R. (2013). Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine, 9(5), 665-674. doi:10.1016/j.nano.2012.11.006
321	Rungta, R. L., Choi, H. B., Lin, P. J., Ko, R. W., Ashby, D., Nair, J., Manoharan, M., Cullis, P. R., & Macvicar, B. A. (2013). Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Molecular Therapy: Nucleic Acids, 2, e136. doi:10.1038/mtna.2013.65
320	Mui, B. L., Tam, Y. K., Jayaraman, M., Ansell, S. M., Du, X., Tam, Y. Y., Lin, P. J., Chen, S., Narayanannair, J. K., Rajeev, K. G., Manoharan, M., Akinc, A., Maier, M. A., Cullis, P., Madden, T. D., & Hope, M. J. (2013). Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy: Nucleic Acids, 2, e139. doi:10.1038/mtna.2013.66
319	Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., Zhang, X., Wang, Q., Panesar, S., Hutabarat, R., Carioto, M., Hettinger, J., Kandasamy, P., Butler, D., Rajeev, K. G., Pang, B., Charisse, K., Fitzgerald, K., Mui, B. L., Du, X., Cullis, P., Madden, T. D., Hope, M. J., Manoharan, M., & Akinc, A. (2013). Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Molecular Therapy, 21(8), 1570-1578. doi:10.1038/mt.2013.124
318	Lin, P. J., Tam, Y. Y., Hafez, I., Sandhu, A., Chen, S., Ciufolini, M. A., Nabi, I. R., & Cullis, P. R. (2013). Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA. Nanomedicine, 9(2), 233-246. doi:10.1016/j.nano.2012.05.019
317	Allen, T. M., & Cullis, P. R. (2013). Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews, 65(1), 36-48. doi:10.1016/j.addr.2012.09.037
316	Zhigaltsev, I. V., Belliveau, N. M., Hafez, I., Leung, A. K. K., Huft, J., Hansen, C. L., & Cullis, P. R. (2012). Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing. Langmuir, 28(7), 3633-3640. doi:10.1021/la204833h
315	Novobrantseva, T. I., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K., Querbes, W., Ge, P., Ruda, V. M., Milstein, S., Speciner, L., Duncan, R., Barros, S., Basha, G., Cullis, P., Akinc, A., Donahoe, J. S., Narayanannair Jayaprakash, K., Jayaraman, M., Bogorad, R. L., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, F. K., Weissleder, R., Langer, R., Anderson, D. G., de Fougerolles, A., Nahrendorf, M., & Koteliansky, V. (2012). Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular Therapy: Nucleic Acids, 1, e4. doi:10.1038/mtna.2011.3
314	Leung, A. K., Hafez, I. M., Baoukina, S., Belliveau, N. M., Zhigaltsev, I. V., Afshinmanesh, E., Tieleman, D. P., Hansen, C. L., Hope, M. J., & Cullis, P. R. (2012). Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core. Journal of Physical Chemistry C: Nanomaterials and Interfaces, 116(34), 18440-18450. doi:10.1021/jp303267y
313	Lee, J. B., Zhang, K., Tam, Y. Y., Tam, Y. K., Belliveau, N. M., Sung, V. Y., Lin, P. J., LeBlanc, E., Ciufolini, M. A., Rennie, P. S., & Cullis, P. R. (2012). Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. International Journal of Cancer, 131(5), E781-E790. doi:10.1002/ijc.27361
312	Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., Rajeev, K. G., Hafez, I. M., Akinc, A., Maier, M. A., Tracy, M. A., Cullis, P. R., Madden, T. D., Manoharan, M., & Hope, M. J. (2012). Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angewandte Chemie International Edition in English, 51(34), 8529-8533. doi:10.1002/anie.201203263
311	Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., Hansen, C. L., & Cullis, P. R. (2012). Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA. Molecular Therapy: Nucleic Acids, 1, e37. doi:10.1038/mtna.2012.28
310	Geetha-Loganathan, P., Nimmagadda, S., Hafez, I., Fu, K., Cullis, P. R., & Richman, J. M. (2011). Development of high-concentration lipoplexes for in vivo gene function studies in vertebrate embryos. Developmental Dynamics, 240(9), 2108-2119. doi:10.1002/dvdy.22708
309	Basha, G., Novobrantseva, T. I., Rosin, N., Tam, Y. Y., Hafez, I. M., Wong, M. K., Sugo, T., Ruda, V. M., Qin, J., Klebanov, B., Ciufolini, M., Akinc, A., Tam, Y. K., Hope, M. J., & Cullis, P. R. (2011). Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Molecular Therapy, 19(12), 2186-2200. doi:10.1038/mt.2011.190
308	Zhigaltsev, I. V., Winters, G., Srinivasulu, M., Crawford, J., Wong, M., Amankwa, L., Waterhouse, D., Masin, D., Webb, M., Harasym, N., Heller, L., Bally, M. B., Ciufolini, M. A., Cullis, P. R., & Maurer, N. (2010). Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles. Journal of Controlled Release, 144(3), 332-340. doi:10.1016/j.jconrel.2010.02.029
307	Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W., Stebbing, D., Crosley, E. J., Yaworski, E., Hafez, I. M., Dorkin, J. R., Qin, J., Lam, K., Rajeev, K. G., Wong, K. F., Jeffs, L. B., Nechev, L., Eisenhardt, M. L., Jayaraman, M., Kazem, M., Maier, M. A., Srinivasulu, M., Weinstein, M. J., Chen, Q., Alvarez, R., Barros, S. A., De, S., Klimuk, S. K., Borland, T., Kosovrasti, V., Cantley, W. L., Tam, Y. K., Manoharan, M., Ciufolini, M. A., Tracy, M. A., de Fougerolles, A., MacLachlan, I., Cullis, P. R., Madden, T. D., & Hope, M. J. (2010). Rational design of cationic lipids for siRNA delivery. Nature Biotechnology, 28(2), 172-176. doi:10.1038/nbt.1602
306	de Jong, S. D., Basha, G., Wilson, K. D., Kazem, M., Cullis, P., Jefferies, W., & Tam, Y. (2010). The Immunostimulatory Activity of Unmethylated and Methylated CpG Oligodeoxynucleotide Is Dependent on Their Ability To Colocalize with TLR9 in Late Endosomes. The Journal of Immunology, 184(11), 6092-6102. doi:10.4049/jimmunol.0802442
305	Wilson, K. D., de Jong, S. D., Kazem, M., Lall, R., Hope, M. J., Cullis, P. R., & Tam, Y. K. (2009). The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine. Journal of Gene Medicine, 11(1), 14-25. doi:10.1002/jgm.1267
304	Cressman, S., Sun, Y., Maxwell, E. J., Fang, N., Chen, D. D. Y., & Cullis, P. R. (2009). Binding and Uptake of RGD-Containing Ligands to Cellular αvβ3 Integrins. International Journal of Peptide Research and Therapeutics, 15(1), 49-59. doi:10.1007/s10989-008-9163-y
303	Cressman, S., Dobson, I., Lee, J. B., Tam, Y. Y. C., & Cullis, P. R. (2009). Synthesis of a Labeled RGD−Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. Bioconjugate Chemistry, 20(7), 1404-1411. doi:10.1021/bc900041f
302	Chikh, G., de Jong, S. D., Sekirov, L., Raney, S. G., Kazem, M., Wilson, K. D., Cullis, P. R., Dutz, J. P., & Tam, Y. K. (2009). Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles. International Immunology, 21(7), 757-767. doi:10.1093/intimm/dxp044
301	Sun, Y., Cressman, S., Fang, N., Cullis, P. R., & Chen, D. D. Y. (2008). Capillary Electrophoresis Frontal Analysis for Characterization of αvβ3 Integrin Binding Interactions. Analytical Chemistry, 80(9), 3105-3111. doi:10.1021/ac701604a
300	Raney, S. G., Wilson, K. D., Sekirov, L., Chikh, G., de Jong, S. D., Cullis, P. R., & Tam, Y. K. (2008). The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN. Journal of Drug Targeting, 16(7), 564-577. doi:10.1080/10611860802228756
299	Johnston, M. J., Edwards, K., Karlsson, G., & Cullis, P. R. (2008). Influence of drug-to-lipid ratio on drug release properties and liposome integrity in liposomal doxorubicin formulations. Journal of Liposome Research, 18(2), 145-157. doi:10.1080/08982100802129372
298	Fenske, D. B., & Cullis, P. R. (2008). Liposomal nanomedicines. Expert Opinion on Drug Delivery, 5(1), 25-44. doi:10.1517/17425247.5.1.25
297	Fenske, D. B., Chonn, A., & Cullis, P. R. (2008). Liposomal nanomedicines: an emerging field. Toxicologic Pathology, 36(1), 21-29. doi:10.1177/0192623307310960
296	Wilson, K. D., Raney, S. G., Sekirov, L., Chikh, G., de Jong, S. D., Cullis, P. R., & Tam, Y. K. (2007). Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles. International immunopharmacology, 7(8), 1064-1075. doi:10.1016/j.intimp.2007.04.002
295	Webb, M. S., Boman, N. L., Masin, D., Yapp, D., Ramsay, E., Chiu, G. N. C., Cullis, P. R., & Bally, M. B. (2007). A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity. Letters in Drug Design & Discovery, 4(6), 426-433. doi:10.2174/157018007781387782
294	Maurer, N., Zhigaltsev, I., & Cullis, P. R. (2007). Encapsulation of Nucleic Acid–Based Therapeutics. In G. Gregoriadis (Ed.), Liposome Technology: Entrapment of Drugs and Other Materials into Liposomes (3 ed., Vol. 2, pp. 131-148). Boca Raton: CRC Press.
293	Johnston, M. J., Semple, S. C., Klimuk, S. K., Ansell, S., Maurer, N., & Cullis, P. R. (2007). Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochimica et biophysica acta, 1768(5), 1121-1127. doi:10.1016/j.bbamem.2007.01.019
292	Fenske, D. B., & Cullis, P. R. (2007). Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques. In G. Gregoriadis (Ed.), Liposome Technology: Entrapment of Drugs and Other Materials into Liposomes (3 ed., Vol. 2, pp. 27-50). Boca Raton: CRC Press.
291	de Jonge, J., Leenhouts, J. M., Holtrop, M., Schoen, P., Scherrer, P., Cullis, P. R., Wilschut, J., & Huckriede, A. (2007). Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA. Biochemical Journal, 405(1), 41-49. doi:10.1042/bj20061756
290	de Jong, S., Chikh, G., Sekirov, L., Raney, S., Semple, S., Klimuk, S., Yuan, N., Hope, M., Cullis, P., & Tam, Y. (2007). Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. Cancer Immunology, Immunotherapy, 56(8), 1251-1264. doi:10.1007/s00262-006-0276-x
289	Zhigaltsev, I. V., Maurer, N., Edwards, K., Karlsson, G., & Cullis, P. R. (2006). Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention. Journal of Controlled Release, 110(2), 378-386. doi:10.1016/j.jconrel.2005.10.011
288	Johnston, M. J., Semple, S. C., Klimuk, S. K., Edwards, K., Eisenhardt, M. L., Leng, E. C., Karlsson, G., Yanko, D., & Cullis, P. R. (2006). Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations. Biochimica et biophysica acta, 1758(1), 55-64. doi:10.1016/j.bbamem.2006.01.009
287	Zhigaltsev, I. V., Maurer, N., Akhong, Q. F., Leone, R., Leng, E., Wang, J., Semple, S. C., & Cullis, P. R. (2005). Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention. Journal of Controlled Release, 104(1), 103-111. doi:10.1016/j.jconrel.2005.01.010
286	Waterhouse, D. N., Madden, T. D., Cullis, P. R., Bally, M. B., Mayer, L. D., & Webb, M. S. (2005). Preparation, characterization, and biological analysis of liposomal formulations of vincristine. Methods in Enzymology, 391, 40-57. doi:10.1016/s0076-6879(05)91002-1
285	Semple, S. C., Leone, R., Wang, J., Leng, E. C., Klimuk, S. K., Eisenhardt, M. L., Yuan, Z. N., Edwards, K., Maurer, N., Hope, M. J., Cullis, P. R., & Ahkong, Q. F. (2005). Optimization and characterization of a sphingomyelin/cholesterol liposome formulation of vinorelbine with promising antitumor activity. Journal of Pharmaceutical Sciences, 94(5), 1024-1038. doi:10.1002/jps.20332
284	Sandhu, A. P., Lam, A. M., Fenske, D. B., Palmer, L. R., Johnston, M., & Cullis, P. R. (2005). Calcium enhances the transfection potency of stabilized plasmid-lipid particles. Analytical Biochemistry, 341(1), 156-164. doi:10.1016/j.ab.2005.02.033
283	Maclachlan, I., & Cullis, P. R. (2005). Diffusible-PEG-Lipid Stabilized Plasmid Lipid Particles. Advances in Genetics, 53pa, 157-188. doi:10.1016/s0065-2660(05)53006-2
282	Finn, J. D., Wong, T., & Cullis, P. R. (2005). Investigation of factors responsible for cell line cytoplasmic expression differences. BMC Molecular and Cell Biology, 6(1), 11. doi:10.1186/1471-2199-6-11
281	Finn, J., MacLachlan, I., & Cullis, P. (2005). Factors limiting autogene-based cytoplasmic expression systems. FASEB Journal, 19(6), 608-610. doi:10.1096/fj.04-2769fje
280	Fenske, D. B., & Cullis, P. R. (2005). Entrapment of small molecules and nucleic acid-based drugs in liposomes. Methods in Enzymology, 391, 7-40. doi:10.1016/s0076-6879(05)91001-x
279	Ambegia, E., Ansell, S., Cullis, P., Heyes, J., Palmer, L., & MacLachlan, I. (2005). Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochimica et biophysica acta, 1669(2), 155-163. doi:10.1016/j.bbamem.2005.02.001
278	Abraham, S. A., Waterhouse, D. N., Mayer, L. D., Cullis, P. R., Madden, T. D., & Bally, M. B. (2005). The liposomal formulation of doxorubicin. Methods in Enzymology, 391, 71-97. doi:10.1016/s0076-6879(05)91004-5
277	Hafez, I. M., & Cullis, P. R. (2004). Tunable pH-sensitive liposomes. Methods in Enzymology, 387, 113-134. doi:10.1016/s0076-6879(04)87007-1
276	Finn, J., Lee, A. C., MacLachlan, I., & Cullis, P. (2004). An enhanced autogene-based dual-promoter cytoplasmic expression system yields increased gene expression. Gene Therapy, 11(3), 276-283. doi:10.1038/sj.gt.3302172
275	Fenske, D. B., & Cullis, P. R. (2004). Liposomes: Models of Biological Membranes and Drug Delivery Systems. Physics in Canada, 60(2), 187-194.
274	Chen, T., Palmer, L. R., Fenske, D. B., Lam, A. M., Wong, K. F., & Cullis, P. R. (2004). Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake. Journal of Liposome Research, 14(3-4), 155-173. doi:10.1081/lpr-200033437
273	Chen, T., McIntosh, D., He, Y. H., Kim, J. S., Tirrell, D. A., Scherrer, P., Fenske, D. B., Sandhu, A. P., & Cullis, P. R. (2004). Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pH-dependent intracellular delivery of liposomal contents. Molecular Membrane Biology, 21(6), 385-393. doi:10.1080/09687860400010516
272	Allen, T. M., & Cullis, P. R. (2004). Drug delivery systems: entering the mainstream. Science, 303(5665), 1818-1822. doi:10.1126/science.1095833
271	Palmer, L. R., Chen, T., Lam, A. M., Fenske, D. B., Wong, K. F., MacLachlan, I., & Cullis, P. R. (2003). Transfection properties of stabilized plasmid-lipid particles containing cationic PEG lipids. Biochimica et biophysica acta, 1611(1-2), 204-216. doi:10.1016/s0005-2736(03)00058-0
270	Zhigaltsev, I. V., Maurer, N., Wong, K. F., & Cullis, P. R. (2002). Triggered release of doxorubicin following mixing of cationic and anionic liposomes. Biochimica et biophysica acta, 1565(1), 129-135. doi:10.1016/s0005-2736(02)00543-6
269	Gaucheron, J., Wong, T., Wong, K. F., Maurer, N., & Cullis, P. R. (2002). Synthesis and Properties of Novel Tetraalkyl Cationic Lipids. Bioconjugate Chemistry, 13(3), 671-675. doi:10.1021/bc0101259
268	Fenske, D. B., MacLachlan, I., & Cullis, P. R. (2002). Stabilized plasmid-lipid particles: a systemic gene therapy vector. Methods in Enzymology, 346, 36-71. doi:10.1016/s0076-6879(02)46048-x
267	Cullis, P. R. (2002). Stabilized plasmid-lipid particles for systemic gene therapy. Cellular & Molecular Biology Letters, 7(2), 226.
266	Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., & Scherrer, P. (2001). Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochimica et biophysica acta, 1510(1-2), 152-166. doi:10.1016/s0005-2736(00)00343-6
265	Maurer, N., Wong, K. F., Stark, H., Louie, L., McIntosh, D., Wong, T., Scherrer, P., Semple, S. C., & Cullis, P. R. (2001). Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes. Biophysical journal, 80(5), 2310-2326. doi:10.1016/s0006-3495(01)76202-9
264	Maurer, N., Fenske, D. B., & Cullis, P. R. (2001). Developments in liposomal drug delivery systems. Expert Opinion on Biological Therapy, 1(6), 923-947. doi:10.1517/14712598.1.6.923
263	Hafez, I. M., Maurer, N., & Cullis, P. R. (2001). On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Therapy, 8(15), 1188-1196. doi:10.1038/sj.gt.3301506
262	Hafez, I. M., & Cullis, P. R. (2001). Roles of lipid polymorphism in intracellular delivery. Advanced Drug Delivery Reviews, 47(2-3), 139-148. doi:10.1016/s0169-409x(01)00103-x
261	Fenske, D. B., Palmer, L. R., Chen, T., Wong, K. F., & Cullis, P. R. (2001). Cationic poly(ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells. Biochimica et biophysica acta, 1512(2), 259-272. doi:10.1016/s0005-2736(01)00327-3
260	Fenske, D. B., MacLachlan, I., & Cullis, P. R. (2001). Long-circulating vectors for the systemic delivery of genes. Current Opinion in Molecular Therapeutics, 3(2), 153-158. Retrieved from http://europepmc.org/abstract/MED/11338928
259	Webb, M. S., Sarris, A. H., Cabanillas, F., Mayer, L. D., Bally, M. B., Burge, C., & Cullis, P. R. (2000). Clinical and Preclinical Pharmacology of Liposomal Vincristine. Journal of Liposome Research, 10(4), 501-512. doi:10.3109/08982100009031114
258	Tam, P., Monck, M., Lee, D., Ludkovski, O., Leng, E. C., Clow, K., Stark, H., Scherrer, P., Graham, R. W., & Cullis, P. R. (2000). Stabilized plasmid-lipid particles for systemic gene therapy. Gene Therapy, 7(21), 1867-1874. doi:10.1038/sj.gt.3301308
257	Scherrer, P., Maurer, N., Monck, M., Saravolac, E., Zhang, Y. P., Wheeler, J., Tam, P., Lam, A., & Cullis, P. R. (2000). Design and Properties of a Lipid-Based Carrier System for Systemic Gene Therapy. In G. Gregoriadis & B. McCormack (Eds.), Targeting of Drugs: Strategies for Gene Constructs and Delivery (Vol. 323, pp. 165-185). Amsterdam, Washington, D. C.: IOS Press.
256	Saravolac, E. G., Ludkovski, O., Skirrow, R., Ossanlou, M., Zhang, Y. P., Giesbrecht, C., Thompson, J., Thomas, S., Stark, H., Cullis, P. R., & Scherrer, P. (2000). Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optimal transfection activity. Journal of Drug Targeting, 7(6), 423-437. doi:10.3109/10611860009102217
255	Oja, C., Tardi, P., Schutze-Redelmeier, M., & Cullis, P. R. (2000). Doxorubicin entrapped within liposome-associated antigens results in a selective inhibition of the antibody response to the linked antigen. Biochimica et biophysica acta, 1468(1-2), 31-40. doi:10.1016/s0005-2736(00)00178-4
254	Monck, M. A., Mori, A., Lee, D., Tam, P., Wheeler, J. J., Cullis, P. R., & Scherrer, P. (2000). Stabilized Plasmid–Lipid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumors following Intravenous Injection. Journal of Drug Targeting, 7(6), 439-452. doi:10.3109/10611860009102218
253	MacLachlan, I., Cullis, P. R., & Graham, R. W. (2000). Synthetic Virus Systems for Systemic Gene Therapy. In N. S. Templeton & D. D. Lasic (Eds.), Gene Therapy: Therapeutic Mechanisms and Strategies (pp. 267-290). New York: Marcel Dekker Inc.
252	Lam, A. M., & Cullis, P. R. (2000). Calcium enhances the transfection potency of plasmid DNA-cationic liposome complexes. Biochimica et biophysica acta, 1463(2), 279-290. doi:10.1016/s0005-2736(99)00219-9
251	Huang, Y. Y., Maurer, N., & Cullis, P. R. (2000). Developing serum-stabilized cationic liposome-dna particles for gene therapy by preformed vesicles and ethanol method. Biomedical Engineering: Applications, Basis and Communications, 12, 217-222.
250	Hafez, I. M., & Cullis, P. R. (2000). Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. Biochimica et biophysica acta, 1463(1), 107-114. doi:10.1016/s0005-2736(99)00186-8
249	Hafez, I. M., Ansell, S., & Cullis, P. R. (2000). Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids. Biophysical journal, 79(3), 1438-1446. doi:10.1016/S0006-3495(00)76395-8
248	Cullis, P. R., & Huang, Y. Y. (2000). Transfection of BHK cell by serum-stabilized cationic liposome-DNA particles. Biomedical Engineering: Applications, Basis and Communications, 12(6), 281-287.
247	Cullis, P. R. (2000). Commentary: Liposomes by Accident. Journal of Liposome Research, 10(2-3), ix-xxiv. doi:10.3109/08982100009029380
246	Chen, T., Wong, K. F., Fenske, D. B., Palmer, L. R., & Cullis, P. R. (2000). Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups. Bioconjugate Chemistry, 11(3), 433-437. doi:10.1021/bc990171x
245	Ansell, S. M., Harasym, T. O., Tardi, P. G., Buchkowsky, S. S., Bally, M. B., & Cullis, P. R. (2000). Antibody conjugation methods for active targeting of liposomes. Methods In Molecular Medicine, 25, 51-68. doi:10.1385/1-59259-075-6:51
244	Zhang, Y. P., Sekirov, L., Saravolac, E. G., Wheeler, J. J., Tardi, P., Clow, K., Leng, E., Sun, R., Cullis, P. R., & Scherrer, P. (1999). Stabilized plasmid-lipid particles for regional gene therapy: formulation and transfection properties. Gene Therapy, 6(8), 1438-1447. doi:10.1038/sj.gt.3300965
243	Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999). Stabilized plasmid-lipid particles: construction and characterization. Gene Therapy, 6(2), 271-281. doi:10.1038/sj.gt.3300821
242	Schoen, P., Chonn, A., Cullis, P. R., Wilschut, J., & Scherrer, P. (1999). Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles. Gene Therapy, 6(5), 823-832. doi:10.1038/sj.gt.3300919
241	Mok, K. W., Lam, A. M., & Cullis, P. R. (1999). Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochimica et biophysica acta, 1419(2), 137-150. doi:10.1016/s0005-2736(99)00059-0
240	Maurer-Spurej, E., Wong, K. F., Maurer, N., Fenske, D. B., & Cullis, P. R. (1999). Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients. Biochimica et biophysica acta, 1416(1-2), 1-10. doi:10.1016/s0005-2736(98)00204-1
239	Maurer, N., Mori, A., Palmer, L., Monck, M. A., Mok, K. W., Mui, B., Akhong, Q. F., & Cullis, P. R. (1999). Lipid-based systems for the intracellular delivery of genetic drugs. Molecular Membrane Biology, 16(1), 129-140. doi:10.1080/096876899294869
238	MacLachlan, I., Cullis, P., & Graham, R. W. (1999). Progress towards a synthetic virus for systemic gene therapy. Current Opinion in Molecular Therapeutics, 1(2), 252-259
237	Chen, T., Choi, L. S., Einstein, S., Klippenstein, M. A., Scherrer, P., & Cullis, P. R. (1999). Proton-Induced Permeability and Fusion of Large Unilamellar Vesicles by Covalently Conjugated Poly(2-Ethylacrylic Acid). Journal of Liposome Research, 9(3), 387-405. doi:10.3109/08982109909018658
236	Webb, M. S., Saxon, D., Wong, F. M., Lim, H. J., Wang, Z., Bally, M. B., Choi, L. S., Cullis, P. R., & Mayer, L. D. (1998). Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine. Biochimica et biophysica acta, 1372(2), 272-282. doi:10.1016/s0005-2736(98)00077-7
235	Semple, S. C., Chonn, A., & Cullis, P. R. (1998). Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo. Advanced Drug Delivery Reviews, 32(1-2), 3-17. doi:10.1016/s0169-409x(97)00128-2
234	Schmid, S. L., & Cullis, P. R. (1998). Membrane sorting. Endosome marker is fat not fiction. Nature, 392(6672), 135-136. doi:10.1038/32309
233	Mori, A., Chonn, A., Choi, L. S., Israels, A., Monck, M. A., & Cullis, P. R. (1998). Stabilization and Regulated Fusion of Liposomes Containing a Cationic Lipid Using Amphipathic Polyethyleneglycol Derivatives. Journal of Liposome Research, 8(2), 195-211. doi:10.3109/08982109809035526
232	Mayer, L. D., Cullis, P. R., & Bally, M. B. (1998). Chapter 4.2 - Designing therapeutically optimized liposomal anticancer delivery systems: Lessons from conventional liposomes. In D. D. Lasic & D. Papahadjopoulos (Eds.), Medical Applications of Liposomes (pp. 231-257). Amsterdam: Elsevier Science B.V.
231	Maurer, N., Wong, K. F., Hope, M. J., & Cullis, P. R. (1998). Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study. Biochimica et biophysica acta, 1374(1-2), 9-20. doi:10.1016/s0005-2736(98)00125-4
230	Fenske, D. B., Wong, K. F., Maurer, E., Maurer, N., Leenhouts, J. M., Boman, N., Amankwa, L., & Cullis, P. R. (1998). Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients. Biochimica et biophysica acta, 1414(1-2), 188-204. doi:10.1016/s0005-2736(98)00166-7
229	Chonn, A., & Cullis, P. R. (1998). Recent advances in liposome technologies and their applications for systemic gene delivery. Advanced Drug Delivery Reviews, 30(1-3), 73-83. doi:10.1016/s0169-409x(97)00108-7
228	Cheung, B. C., Sun, T. H., Leenhouts, J. M., & Cullis, P. R. (1998). Loading of doxorubicin into liposomes by forming Mn2+-drug complexes. Biochimica et biophysica acta, 1414(1-2), 205-216. doi:10.1016/s0005-2736(98)00168-0
227	Boman, N. L., Cullis, P. R., Mayer, L. D., Bally, M. B., & Webb, M. S. (1998). Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations. In M. C. Woodle & G. Storm (Eds.), Long Circulating Liposomes: Old Drugs, New Therapeutics (pp. 29-49). Berlin, Heidelberg: Springer Berlin Heidelberg
226	Bally, M. B., Lim, H., Cullis, P. R., & Mayer, L. D. (1998). Controlling the Drug Delivery Attributes of Lipid-Based Drug Formulations. Journal of Liposome Research, 8(3), 299-335. doi:10.3109/08982109809035537
225	Tardi, P. G., Swartz, E. N., Harasym, T. O., Cullis, P. R., & Bally, M. B. (1997). An immune response to ovalbumin covalently coupled to liposomes is prevented when the liposomes used contain doxorubicin. Journal of Immunological Methods, 210(2), 137-148. doi:10.1016/s0022-1759(97)00178-6
224	Parr, M. J., Masin, D., Cullis, P. R., & Bally, M. B. (1997). Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). Journal of Pharmacology and Experimental Therapeutics, 280(3), 1319-1327
223	Mok, K. W., & Cullis, P. R. (1997). Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA. Biophysical journal, 73(5), 2534-2545. doi:10.1016/S0006-3495(97)78282-1
222	Harasym, T. O., Cullis, P. R., & Bally, M. B. (1997). Intratumor distribution of doxorubicin following i.v. administration of drug encapsulated in egg phosphatidylcholine/cholesterol liposomes. Cancer Chemotherapy and Pharmacology, 40(4), 309-317. doi:10.1007/s002800050662
221	Felgner, P. L., Barenholz, Y., Behr, J. P., Cheng, S. H., Cullis, P. R., Huang, L., Jessee, J. A., Seymour, L., Szoka, F., Thierry, A. R., Wagner, E., & Wu, G. (1997). Nomenclature for Synthetic Gene Delivery Systems. Human Gene Therapy, 8(5), 511-512. doi:10.1089/hum.1997.8.5-511
220	Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., & Fenske, D. B. (1997). Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochimica et biophysica acta, 1331(2), 187-211. doi:10.1016/s0304-4157(97)00006-3
219	Bailey, A. L., Monck, M. A., & Cullis, P. R. (1997). pH-induced destabilization of lipid bilayers by a lipopeptide derived from influenza hemagglutinin. Biochimica et biophysica acta, 1324(2), 232-244. doi:10.1016/s0005-2736(96)00228-3
218	Bailey, A. L., & Cullis, P. R. (1997). Membrane fusion with cationic liposomes: effects of target membrane lipid composition. Biochemistry, 36(7), 1628-1634. doi:10.1021/bi961173x
217	Bailey, A. L., & Cullis, P. R. (1997). Chapter 9 - Liposome Fusion. In R. M. Epand (Ed.), Current Topics in Membranes (Vol. 44, pp. 359-373): Academic Press
216	Tardi, P. G., Boman, N. L., & Cullis, P. R. (1996). Liposomal doxorubicin. Journal of Drug Targeting, 4(3), 129-140. doi:10.3109/10611869609015970
215	Semple, S. C., Chonn, A., & Cullis, P. R. (1996). Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry, 35(8), 2521-2525. doi:10.1021/bi950414i
214	Oja, C. D., Semple, S. C., Chonn, A., & Cullis, P. R. (1996). Influence of dose on liposome clearance: critical role of blood proteins. Biochimica et biophysica acta, 1281(1), 31-37. doi:10.1016/0005-2736(96)00003-x
213	Lafleur, M., Bloom, M., Eikenberry, E. F., Gruner, S. M., Han, Y., & Cullis, P. R. (1996). Correlation between lipid plane curvature and lipid chain order. Biophysical journal, 70(6), 2747-2757. doi:10.1016/S0006-3495(96)79844-2
212	Holland, J. W., Hui, C., Cullis, P. R., & Madden, T. D. (1996). Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine. Biochemistry, 35(8), 2618-2624. doi:10.1021/bi952000v
211	Holland, J. W., Cullis, P. R., & Madden, T. D. (1996). Poly(ethylene glycol)-lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids. Biochemistry, 35(8), 2610-2617. doi:10.1021/bi951999j
210	Fenske, D. B., & Cullis, P. R. (1996). Lipid Polymorphism. In The Encyclopedia of Nuclear Magnetic Resonance (pp. 2730-2735). New York: John Wiley & Sons
209	Cullis, P. R., Fenske, D. B., & Hope, M. J. (1996). Chapter 1 - Physical properties and functional roles of lipids in membranes. In D. E. Vance & J. E. Vance (Eds.), New Comprehensive Biochemistry (Vol. 31, pp. 1-33): Elsevier
208	Boman, N. L., Tron, V. A., Bally, M. B., & Cullis, P. R. (1996). Vincristine-induced dermal toxicity is significantly reduced when the drug is given in liposomes. Cancer Chemotherapy and Pharmacology, 37(4), 351-355. doi:10.1007/s002800050396
207	Mui, B. L., Döbereiner, H. G., Madden, T. D., & Cullis, P. R. (1995). Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles. Biophysical journal, 69(3), 930-941. doi:10.1016/S0006-3495(95)79967-2
206	Longman, S. A., Tardi, P. G., Parr, M. J., Choi, L., Cullis, P. R., & Bally, M. B. (1995). Accumulation of protein-coated liposomes in an extravascular site: influence of increasing carrier circulation lifetimes. Journal of Pharmacology and Experimental Therapeutics, 275(3), 1177-1184
205	Longman, S. A., Cullis, P. R., Choi, L., de Jong, G., & Bally, M. B. (1995). A two-step targeting approach for delivery of doxorubicin-loaded liposomes to tumour cells in vivo. Cancer Chemotherapy and Pharmacology, 36(2), 91-101. doi:10.1007/bf00689191
204	Longman, S. A., Cullis, P. R., & Bally, M. B. (1995). A model approach for assessing liposome targeting in vivo. Drug Delivery, 2(3-4), 156-165. doi:10.3109/10717549509031365
203	Harasym, T. O., Tardi, P., Longman, S. A., Ansell, S. M., Bally, M. B., Cullis, P. R., & Choi, L. S. (1995). Poly(ethylene glycol)-modified phospholipids prevent aggregation during covalent conjugation of proteins to liposomes. Bioconjugate Chemistry, 6(2), 187-194. doi:10.1021/bc00032a006
202	Fenske, D. B., Monck, M. A., Cullis, P. R., & Hope, M. J. (1995). The functional roles of lipids in biological membranes. In A. G. lee (Ed.), Biomembranes: A Multi-Volume Treatise (Vol. 1, pp. 1-28): JAI
201	Cullis, P. R., & Hope, M. J. (1995). Liposomes, dimitri papahadjopoulos, and us. Journal of Liposome Research, 5(4), 829-836. doi:10.3109/08982109509012684
200	Chonn, A., Semple, S. C., & Cullis, P. R. (1995). β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of "Non-self" Particles. Journal of Biological Chemistry, 270(43), 25845-25849. doi:10.1074/jbc.270.43.25845
199	Chonn, A., & Cullis, P. R. (1995). Recent advances in liposomal drug-delivery systems. Current Opinion in Biotechnology, 6(6), 698-708. doi:10.1016/0958-1669(95)80115-4
198	Boman, N. L., Cullis, P. R., Bally, M. B., & Mayer, L. D. (1995). Preclinical and Clinical Activity of Liposomal Doxorubicin. In Liposomes in Biomedical Applications (pp. 85-103): Harwood Academic Publishers
197	Boman, N. L., Bally, M. B., Cullis, P. R., Mayer, L. D., & Webb, M. S. (1995). Encapsulation of Vincristine in Liposomes Reduces its Toxicity and Improves its Anti-Tumor Efficacy. Journal of Liposome Research, 5(3), 523-541. doi:10.3109/08982109509010240
196	Wheeler, J. J., Veiro, J. A., & Cullis, P. R. (1994). Ionophore-mediated loading of Ca 2+ into large unilamellar vesicles in response to transmembrane pH gradients. Molecular Membrane Biology, 11(3), 151-157. doi:10.3109/09687689409162233
195	Parr, M. J., Ansell, S. M., Choi, L. S., & Cullis, P. R. (1994). Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles. Biochimica et biophysica acta, 1195(1), 21-30. doi:10.1016/0005-2736(94)90004-3
194	Mui, B. L., Cullis, P. R., Pritchard, P. H., & Madden, T. D. (1994). Influence of plasma on the osmotic sensitivity of large unilamellar vesicles prepared by extrusion. Journal of Biological Chemistry, 269(10), 7364-7370
193	Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994). The Use of Transmembrane pH Gradient-Driven Drug Encapsulation in the Pharmacodynamic Evaluation of Liposomal Doxorubicin. Journal of Liposome Research, 4(1), 529-553. doi:10.3109/08982109409037060
192	Lewis, R. N., McElhaney, R. N., Monck, M. A., & Cullis, P. R. (1994). Studies of highly asymmetric mixed-chain diacyl phosphatidylcholines that form mixed-interdigitated gel phases: Fourier transform infrared and 2H NMR spectroscopic studies of hydrocarbon chain conformation and orientational order in the liquid-crystalline state. Biophysical journal, 67(1), 197-207. doi:10.1016/s0006-3495(94)80470-9
191	Devine, D. V., Wong, K., Serrano, K., Chonn, A., & Cullis, P. R. (1994). Liposome-complement interactions in rat serum: implications for liposome survival studies. Biochimica et biophysica acta, 1191(1), 43-51. doi:10.1016/0005-2736(94)90231-3
190	Chonn, A., Semple, S. C., & Cullis, P. R. (1994). Protein-Membrane Interactions in the Complex Biological Milieu. In Biological Membranes: Structure, Biogenesis and Dynamics (pp. 101-106). Berlin, Heidelberg: Springer
189	Chakrabarti, A. C., Clark-Lewis, I., & Cullis, P. R. (1994). Influence of Charge, Charge Distribution, and Hydrophobicity on the Transport of Short Model Peptides into Liposomes in Response to Transmembrane pH Gradients. Biochemistry, 33(28), 8479-8485. doi:10.1021/bi00194a012
188	Boman, N. L., Masin, D., Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994). Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors. Cancer Research, 54(11), 2830-2833
187	Bally, M. B., Masin, D., Nayar, R., Cullis, P. R., & Mayer, L. D. (1994). Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice. Cancer Chemotherapy and Pharmacology, 34(2), 137-146. doi:10.1007/BF00685931
186	Bailey, A. L., & Cullis, P. R. (1994). Modulation of Membrane Fusion by Asymmetric Transbilayer Distributions of Amino Lipids. Biochemistry, 33(42), 12573-12580. doi:10.1021/bi00208a007
185	Parr, M. J., Bally, M. B., & Cullis, P. R. (1993). The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade. Biochimica et biophysica acta, 1168(2), 249-252. doi:10.1016/0005-2760(93)90132-s
184	Mui, B. L., Cullis, P. R., Evans, E. A., & Madden, T. D. (1993). Osmotic properties of large unilamellar vesicles prepared by extrusion. Biophysical journal, 64(2), 443-453. doi:10.1016/S0006-3495(93)81385-7
183	Monck, M. A., Bloom, M., Lafleur, M., Lewis, R. N. A. H., McElhaney, R. N., & Cullis, P. R. (1993). Evidence for two pools of cholesterol in the Acholeplasma laidlawii strain B membrane: A deuterium NMR and DSC study. Biochemistry, 32(12), 3081-3088. doi:10.1021/bi00063a020
182	Mayer, L. D., Nayar, R., Thies, R. L., Boman, N. L., Cullis, P. R., & Bally, M. B. (1993). Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia. Cancer Chemotherapy and Pharmacology, 33(1), 17-24. doi:10.1007/bf00686017
181	Mayer, L. D., Madden, T. D., Bally, M. B., & Cullis, P. R. (1993). pH Gradient-Mediated Drug Entrapment in Liposomes. In Liposome Technology: Entrapment of Drugs and Other Materials (2 ed., Vol. 2, pp. 27-44)
180	Loughrey, H. C., Choi, L. S., Wong, K. F., Cullis, P. R., & Bally, M. B. (1993). Preparation of Streptavidin-Liposomes for Use in Ligand-Specific Targeting Applications. In Liposome Technology: Interactions of Liposomes with the Biological Milieu (2 ed., Vol. 3, pp. 163-178)
179	Kanter, P. M., Bullard, G. A., Pilkiewicz, F. G., Mayer, L. D., Cullis, P. R., & Pavelic, Z. P. (1993). Preclinical toxicology study of liposome encapsulated doxorubicin (TLC D-99): comparison with doxorubicin and empty liposomes in mice and dogs. In Vivo, 7(1), 85-95
178	Hope, M. J., Nayar, R., Mayer, L. D., & Cullis, P. R. (1993). Reduction of Liposome Size and Preparation of Unilamellar Vesicles by Extrusion Techniques. In Liposome Technology: Liposome Preparation and Related Techniques (2 ed., Vol. 1, pp. 123). Boca Raton, FL: CRC Press, Inc.
177	Harrigan, P. R., Wong, K. F., Redelmeier, T. E., Wheeler, J. J., & Cullis, P. R. (1993). Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients. Biochimica et biophysica acta, 1149(2), 329-338. doi:10.1016/0005-2736(93)90218-o
176	Fenske, D. B., & Cullis, P. R. (1993). Acyl chain orientational order in large unilamellar vesicles: comparison with multilamellar liposomes: a 2H and 31P nuclear magnetic resonance study. Biophysical journal, 64(5), 1482-1491. doi:10.1016/S0006-3495(93)81515-7
175	Embree, L., Gelmon, K. A., Lohr, A., Mayer, L. D., Coldman, A. J., Cullis, P. R., Palaitis, W., Pilkiewicz, F. G., Hudon, N. J., Heggie, J. R., & Goldie, J. H. (1993). Chromatographic Analysis and Pharmacokinetics of Liposome-Encapsulated Doxorubicin in Non-Small-Cell Lung Cancer Patients. Journal of Pharmaceutical Sciences, 82(6), 627-634. doi:10.1002/jps.2600820617
174	Boman, N. L., Mayer, L. D., & Cullis, P. R. (1993). Optimization of the retention properties of vincristine in liposomal systems. Biochimica et biophysica acta, 1152(2), 253-258. doi:10.1016/0005-2736(93)90256-Y
173	Wilschut, J., Scholma, J., Eastman, S. J., Hope, M. J., & Cullis, P. R. (1992). Ca(2+)-induced fusion of phospholipid vesicles containing free fatty acids: modulation by transmembrane pH gradients. Biochemistry, 31(10), 2629-2636. doi:10.1021/bi00125a001
172	Monck, M. A., Bloom, M., Lafleur, M., Lewis, R. N. A. H., McElhaney, R. N., & Cullis, P. R. (1992). Influence of lipid composition on the orientational order in Acholeplasma laidlawii strain B membranes: A deuterium NMR study. Biochemistry, 31(41), 10037-10043. doi:10.1021/bi00156a025
171	Kitson, N., Monck, M. A., Wong, K., Thewalt, J., & Cullis, P. R. (1992). The influence of cholesterol 3-sulphate on phase behaviour and hydrocarbon order in model membrane systems. Biochimica et biophysica acta, 1111(1), 127-133. doi:10.1016/0005-2736(92)90282-Q
170	Harrigan, P. R., Hope, M. J., Redelmeier, T. E., & Cullis, P. R. (1992). Determination of transmembrane pH gradients and membrane potentials in liposomes. Biophysical journal, 63(5), 1336-1345. doi:10.1016/S0006-3495(92)81711-3
169	Fenske, D. B., & Cullis, P. R. (1992). Chemical exchange between lamellar and non-lamellar lipid phases. A one- and two-dimensional 31P-NMR study. Biochimica et biophysica acta, 1108(2), 201-209. doi:10.1016/0005-2736(92)90026-I
168	Eastman, S. J., Hope, M. J., Wong, K. F., & Cullis, P. R. (1992). Influence of phospholipid asymmetry on fusion between large unilamellar vesicles. Biochemistry, 31(17), 4262-4268. doi:10.1021/bi00132a016
167	Chonn, A., Semple, S. C., & Cullis, P. R. (1992). Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. Journal of Biological Chemistry, 267(26), 18759-18765.
166	Chonn, A., & Cullis, P. R. (1992). Ganglioside GM1 and Hydrophilic Polymers Increase Liposome Circulation Times by Inhibiting the Association of Blood Proteins. Journal of Liposome Research, 2(3), 397-410. doi:10.3109/08982109209010217
165	Chakrabarti, A. C., Veiro, J. A., Wong, N. S., Wheeler, J. J., & Cullis, P. R. (1992). Generation and characterization of iron- and barium-loaded liposomes. Biochimica et biophysica acta, 1108(2), 233-239. doi:10.1016/0005-2736(92)90030-P
164	Chakrabarti, A. C., Clark-Lewis, I., Harrigan, P. R., & Cullis, P. R. (1992). Uptake of basic amino acids and peptides into liposomes in response to transmembrane pH gradients. Biophysical journal, 61(1), 228-234. doi:10.1016/S0006-3495(92)81829-5
163	Eastman, S. J., Hope, M. J., & Cullis, P. R. (1991). Transbilayer transport of phosphatidic acid in response to transmembrane pH gradients. Biochemistry, 30(7), 1740-1745. doi:10.1021/bi00221a002
162	Cullis, P. R., Bally, M. B., Madden, T. D., Mayer, L. D., & Hope, M. J. (1991). pH gradients and membrane transport in liposomal systems. Trends in Biotechnology, 9(1), 268-272. doi:10.1016/0167-7799(91)90088-Y
161	Chonn, A., Semple, S. C., & Cullis, P. R. (1991). Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo. Biochimica et biophysica acta, 1070(1), 215-222. doi:10.1016/0005-2736(91)90167-7
160	Chonn, A., Cullis, P. R., & Devine, D. V. (1991). The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. The Journal of Immunology, 146(12), 4234-4241
159	Veiro, J. A., & Cullis, P. R. (1990). A novel method for the efficient entrapment of calcium in large unilamellar phospholipid vesicles. Biochimica et biophysica acta, 1025(1), 109-115. doi:10.1016/0005-2736(90)90197-V
158	Thies, R. L., Cowens, D. W., Cullis, P. R., Bally, M. B., & Mayer, L. D. (1990). Method for rapid separation of liposome-associated doxorubicin from free doxorubicin in plasma. Analytical Biochemistry, 188(1), 65-71. doi:10.1016/0003-2697(90)90528-h
157	Redelmeier, T. E., Hope, M. J., & Cullis, P. R. (1990). On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients. Biochemistry, 29(12), 3046-3053. doi:10.1021/bi00464a022
156	Mayer, L. D., Tai, L. C., Bally, M. B., Mitilenes, G. N., Ginsberg, R. S., & Cullis, P. R. (1990). Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients. Biochimica et biophysica acta, 1025(2), 143-151. doi:10.1016/0005-2736(90)90091-2
155	Mayer, L. D., Bally, M. B., Loughrey, H., Masin, D., & Cullis, P. R. (1990). Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors. Cancer Research, 50(3), 575-579
154	Mayer, L. D., Bally, M. B., Cullis, P. R., Wilson, S. L., & Emerman, J. T. (1990). Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor. Cancer Letters, 53(2-3), 183-190. doi:10.1016/0304-3835(90)90212-g
153	Mayer, L. D., Bally, M. B., & Cullis, P. R. (1990). Strategies for Optimizing Liposomal Doxorubicin. Journal of Liposome Research, 1(4), 463-480. doi:10.3109/08982109009036008
152	Madden, T. D., Janoff, A. S., & Cullis, P. R. (1990). Incorporation of amphotericin B into large unilamellar vesicles composed of phosphatidylcholine and phosphatidylglycerol. Chemistry and Physics of Lipids, 52(3-4), 189-198. doi:10.1016/0009-3084(90)90114-7
151	Madden, T. D., Harrigan, P. R., Tai, L. C., Bally, M. B., Mayer, L. D., Redelmeier, T. E., Loughrey, H. C., Tilcock, C. P., Reinish, L. W., & Cullis, P. R. (1990). The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey. Chemistry and Physics of Lipids, 53(1), 37-46. doi:10.1016/0009-3084(90)90131-a
150	Loughrey, H. C., Wong, K. F., Choi, L. S., Cullis, P. R., & Bally, M. B. (1990). Protein-liposome conjugates with defined size distributions. Biochimica et biophysica acta, 1028(1), 73-81. doi:10.1016/0005-2736(90)90267-r
149	Loughrey, H. C., Choi, L. S., Cullis, P. R., & Bally, M. B. (1990). Optimized procedures for the coupling of proteins to liposomes. Journal of Immunological Methods, 132(1), 25-35. doi:10.1016/0022-1759(90)90394-B
148	Loughrey, H. C., Bally, M. B., Reinish, L. W., & Cullis, P. R. (1990). The binding of phosphatidylglycerol liposomes to rat platelets is mediated by complement. Journal of Thrombosis and Haemostasis, 64(1), 172-176
147	Lafleur, M., Cullis, P. R., Fine, B., & Bloom, M. (1990). Comparison of the orientational order of lipid chains in the L.alpha. and HII phases. Biochemistry, 29(36), 8325-8333. doi:10.1021/bi00488a018
146	Lafleur, M., Cullis, P. R., & Bloom, M. (1990). Modulation of the orientational order profile of the lipid acyl chain in the Lα phase. European Biophysics Journal, 19(2), 55-62. doi:10.1007/BF00185086
145	Lafleur, M., Bloom, M., & Cullis, P. R. (1990). Lipid polymorphism and hydrocarbon order. Biochemistry and Cell Biology, 68(1), 1-8. doi:10.1139/o90-001
144	Harrigan, P. R., Madden, T. D., & Cullis, P. R. (1990). Protection of liposomes during dehydration or freezing. Chemistry and Physics of Lipids, 52(2), 139-149. doi:10.1016/0009-3084(90)90157-M
143	Cullis, P. R., Tilcock, C. P., & Hope, M. J. (1990). Lipid Polymorphism. In Membrane Fusion. New York: Marcel Dekker, Inc.
142	Chakrabarti, A. C., Veiro, J. A., Wong, N., & Cullis, P. R. (1990). Use of transmembrane pH gradients and A23187 to produce dense iron liposomes. Biochemical Society Transactions, 18(5), 946-947. doi:10.1042/bst0180946
141	Boni, L. T., Perkins, W. R., Minchey, S. R., Bolcsak, L. E., Gruner, S. M., Cullis, P. R., Hope, M. J., & Janoff, A. S. (1990). Polymorphic phase behavior of alpha-tocopherol hemisuccinate. Chemistry and Physics of Lipids, 54(3), 193-203. doi:10.1016/0009-3084(90)90012-G
140	Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., & Mayer, L. D. (1990). Liposomes with entrapped doxorubicin exhibit extended blood residence times. Biochimica et biophysica acta, 1023(1), 133-139. doi:10.1016/0005-2736(90)90018-j
139	Bally, M. B., Nayar, R., Masin, D., Cullis, P. R., & Mayer, L. D. (1990). Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes. Cancer Chemotherapy and Pharmacology, 27(1), 13-19. doi:10.1007/BF00689270
138	Unger, E. C., MacDougall, P., Cullis, P. R., & Tilcock, C. P. (1989). Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI. Magnetic Resonance Imaging, 7(4), 417-423. doi:10.1016/0730-725x(89)90491-8
137	Tilcock, C. P. S., Unger, E., Cullis, P. R., & MacDougall, P. (1989). Liposomal Gd-DTPA: preparation and characterization of relaxivity. Radiology, 171(1), 77-80. doi:10.1148/radiology.171.1.2928549
136	Tilcock, C. P. S., Dempsey, T., Cullis, P. R., & Fisher, D. (1989). The Partitioning of Liposomes of Defined Size and Composition. In D. Fisher & I. A. Sutherland (Eds.), Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology (pp. 179-180). Boston, MA: Springer US.
135	Tilcock, C. P. S., Cullis, P. R., Dempsey, T., Youens, B. N., & Fisher, D. (1989). Aqueous two-phase polymer partitioning of lipid vesicles of defined size and composition. Biochimica et biophysica acta, 979(2), 208-214. doi:10.1016/0005-2736(89)90436-7
134	Tilcock, C. P. S., Chin, R., Veiro, J., Cullis, P. R., & Fisher, D. (1989). Detection of surface charge-related properties in model membrane systems by aqueous two-phase partition. Biochimica et biophysica acta, 986(1), 167-171. doi:10.1016/0005-2736(89)90287-3
133	Redelmeier, T. E., Mayer, L. D., Wong, K. F., Bally, M. B., & Cullis, P. R. (1989). Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients. Biophysical journal, 56(2), 385-393. doi:10.1016/S0006-3495(89)82684-0
132	Post, C. B., Ray, W. J., Jr., & Gorenstein, D. G. (1989). Time-dependent 31P saturation transfer in the phosphoglucomutase reaction. Characterization of the spin system for the Cd(II) enzyme and evaluation of rate constants for the transfer process. Biochemistry, 28(2), 548-558. doi:10.1021/bi00428a021
131	Parmar, Y. I., Sparks, D. L., Frohlich, J., Cullis, P. R., & Pritchard, P. H. (1989). Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy. Journal of Lipid Research, 30(5), 765-771.
130	Ostro, M. J., & Cullis, P. R. (1989). Use of liposomes as injectable-drug delivery systems. American Journal of Hospital Pharmacy, 46(8), 1576-1587.
129	Nayar, R., Hope, M. J., & Cullis, P. R. (1989). Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion technique. Biochimica et biophysica acta, 986(2), 200-206. doi:10.1016/0005-2736(89)90468-9
128	Mayer, L. D., Tai, L. C., Ko, D. S., Masin, D., Ginsberg, R. S., Cullis, P. R., & Bally, M. B. (1989). Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Research, 49(21), 5922-5930.
127	Lafleur, M., Fine, B., Sternin, E., Cullis, P. R., & Bloom, M. (1989). Smoothed orientational order profile of lipid bilayers by 2H-nuclear magnetic resonance. Biophysical journal, 56(5), 1037-1041. doi:10.1016/S0006-3495(89)82749-3
126	Hope, M. J., Wong, K. F., & Cullis, P. R. (1989). Freeze-fracture of lipids and model membrane systems. Journal of Electron Microscopy Technique, 13(4), 277-287. doi:10.1002/jemt.1060130403
125	Hope, M. J., Redelmeier, T. E., Wong, K. F., Rodrigueza, W., & Cullis, P. R. (1989). Phospholipid asymmetry in large unilamellar vesicles induced by transmembrane pH gradients. Biochemistry, 28(10), 4181-4187. doi:10.1021/bi00436a009
124	Eastman, S. J., Wilschut, J., Cullis, P. R., & Hope, M. J. (1989). Intervesicular exchange of lipids with weak acid and weak base characteristics: influence of transmembrane pH gradients. Biochimica et biophysica acta, 981(2), 178-184. doi:10.1016/0005-2736(89)90026-6
123	Doerschuk, C. M., Gie, R. P., Bally, M. B., Cullis, P. R., & Reinish, L. W. (1989). Platelet distribution in rabbits following infusion of liposomes. Journal of Thrombosis and Haemostasis, 61(3), 392-396.
122	Cullis, P. R., Mayer, L. D., Bally, M. B., Madden, T. D., & Hope, M. J. (1989). Generating and loading of liposomal systems for drug-delivery applications. Advanced Drug Delivery Reviews, 3(3), 267-282. doi:10.1016/0169-409X(89)90024-0
121	Balazsovits, J. A. E., Mayer, L. D., Bally, M. B., Cullis, P. R., McDonell, M., Ginsberg, R. S., & Falk, R. E. (1989). Analysis of the effect of liposome encapsulation on the vesicant properties, acute and cardiac toxicities, and antitumor efficacy of doxorubicin. Cancer Chemotherapy and Pharmacology, 23(2), 81-86. doi:10.1007/BF00273522
120	Unger, E., Needleman, P., Cullis, P., & Tilcock, C. (1988). Gadolinium-DTPA liposomes as a potential MRI contrast agent. Work in progress. Investigative radiology, 23(12), 928-932. doi:10.1097/00004424-198812000-00010
119	Tilcock, C. P. S., Sommerman, E. F., Molday, R. S., & Cullis, P. R. (1988). Magnetic Filtration of Vesicles Containing Iron-Dextran Particles. Journal of Liposome Research, 1, 137-150. doi:10.3109/08982108809035987
118	Tilcock, C. P. S., Cullis, P. R., & Gruner, S. M. (1988). Calcium-induced phase separation phenomena in multicomponent unsaturated lipid mixtures. Biochemistry, 27(5), 1415-1420. doi:10.1021/bi00405a004
117	Sternin, E., Fine, B., Bloom, M., Tilcock, C. P., Wong, K. F., & Cullis, P. R. (1988). Acyl chain orientational order in the hexagonal HII phase of phospholipid-water dispersions. Biophysical journal, 54(4), 689-694. doi:10.1016/S0006-3495(88)83004-2
116	Reinish, L. W., Bally, M. B., Loughrey, H. C., & Cullis, P. R. (1988). Interactions of liposomes and platelets. Thrombosis and haemostasis, 60(3), 518-523
115	Nayar, R., Tilcock, C. P. S., Hope, M. J., Cullis, P. R., & Schroit, A. J. (1988). N-Succinyldioleoylphosphatidylethanolamine: structural preferences in pure and mixed model membranes. Biochimica et biophysica acta, 937, 31-41. doi:10.1016/0005-2736(88)90224-6
114	Mayer, L. D., Wong, K. F., Menon, K., Chong, C., Harrigan, P. R., & Cullis, P. R. (1988). Influence of ion gradients on the transbilayer distribution of dibucaine in large unilamellar vesicles. Biochemistry, 27(6), 2053-2060. doi:10.1021/bi00406a036
113	Madden, T. D., Tilcock, C. P. S., Wong, K., & Cullis, P. R. (1988). Spontaneous vesiculation of large multilamellar vesicles composed of saturated phosphatidylcholine and phosphatidylglycerol mixtures. Biochemistry, 27(24), 8724-8730. doi:10.1021/bi00424a006
112	Janoff, A. S., Kurtz, C. L., Jablonski, R. L., Minchey, S. R., Boni, L. T., Gruner, S. M., Cullis, P. R., Mayer, L. D., & Hope, M. J. (1988). Characterization of cholesterol hemisuccinate and α-tocopherol hemisucccinate vesicles. Biochimica et biophysica acta, 941(2), 165-175. doi:10.1016/0005-2736(88)90177-0
111	Janoff, A. S., Boni, L. T., Popescu, M. C., Minchey, S. R., Cullis, P. R., Madden, T. D., Taraschi, T., Gruner, S. M., Shyamsunder, E., & Tate, M. W. (1988). Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proceedings of the National Academy of Sciences of the United States of America, 85(16), 6122-6126. doi:10.1073/pnas.85.16.6122
110	Gruner, S. M., Tate, M. W., Kirk, G. L., So, P. T. C., Turner, D. C., Keane, D. T., Tilcock, C. P. S., & Cullis, P. R. (1988). X-ray diffraction study of the polymorphic behavior of N-methylated dioleoylphosphatidylethanolamine. Biochemistry, 27(8), 2853-2866. doi:10.1021/bi00408a029
109	Cullis, P. R., & Hope, M. J. (1988). Lipid Polymorphism, Lipid Asymmetry and Membrane Fusion. In S. Ohki, D. Doyle, T. D. Flanagan, S. W. Hui, & E. Mayhew (Eds.), Molecular Mechanisms of Membrane Fusion (pp. 37-51). Boston, MA: Springer US
108	Bally, M. B., Mayer, L. D., Loughrey, H., Redelmeier, T., Madden, T. D., Wong, K., Harrigan, P. R., Hope, M. J., & Cullis, P. R. (1988). Dopamine accumulation in large unilamellar vesicle systems induced by transmembrane ion gradients. Chemistry and Physics of Lipids, 47(2), 97-107. doi:10.1016/0009-3084(88)90078-3
107	Bally, M. B., Hope, M. J., Mayer, L. D., Madden, T. D., & Cullis, P. R. (1988). Novel Procedures for Generating and Loading Liposomal Systems (G. Gregoriadis Ed.): John Wiley & Sons Ltd
106	Wong, K. F., Parmar, Y. I., Mayer, L. D., Pritchard, P. H., & Cullis, P. R. (1987). Detection of protein-free lipoprotein analogues with an apolar lipid core by freeze-etch electron microscopy. Biochimica et biophysica acta, 921(2), 411-414. doi:10.1016/0005-2760(87)90044-0
105	Tilcock, C. P. S., & Cullis, P. R. (1987). Lipid Polymorphism. Annals of the New York Academy of Sciences, 492(1), 88-102. doi:10.1111/j.1749-6632.1987.tb48657.x
104	Sparks, D. L., Frohlich, J., Cullis, P. R., & Pritchard, P. H. (1987). Cholesteryl ester transfer activity in plasma measured by using solid-phase-bound high-density lipoprotein. Clinical Chemistry, 33(3), 390-393. doi:10.1093/clinchem/33.3.390
103	Rauch, J., Tannenbaum, H., Senécal, J. L., Janoff, A. S., Cullis, P. R., & Frojmovic, M. M. (1987). Polyfunctional properties of hybridoma lupus anticoagulant antibodies. The Journal of Rheumatology. Supplement, 14 Suppl 13, 132-137
102	Madden, T. D., Hope, M. J., & Cullis, P. R. (1987). Modelling the biological membrane. Biochemical Society Transactions, 15(1), 75
101	Loughrey, H., Bally, M. B., & Cullis, P. R. (1987). A non-covalent method of attaching antibodies to liposomes. Biochimica et biophysica acta, 901(1), 157-160. doi:10.1016/0005-2736(87)90267-7
100	Hope, M. J., & Cullis, P. R. (1987). Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. Journal of Biological Chemistry, 262(9), 4360-4366
99	Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., & Janoff, A. S. (1987). Liposomes as Pharmaceuticals. New York: Marcel Dekker
98	Tilcock, C. P. S., Cullis, P. R., Hope, M. J., & Gruner, S. M. (1986). Polymorphic phase behavior of unsaturated lysophosphatidylethanolamines: A phosphorus-31 NMR and x-ray diffraction study. Biochemistry, 25(4), 816-822. doi:10.1021/bi00352a013
97	Tilcock, C. P. S., Cullis, P. R., & Gruner, S. M. (1986). On the validity of 31P-NMR determinations of phospholipid polymorphic phase behaviour. Chemistry and Physics of Lipids, 40(1), 47-56. doi:10.1016/0009-3084(86)90061-7
96	Richards, R. L., Habbersett, R. C., Scher, I., Janoff, A. S., Schieren, H. P., Mayer, L. D., Cullis, P. R., & Alving, C. R. (1986). Influence of vesicle size on complement-dependent immune damage to liposomes. Biochimica et biophysica acta, 855(2), 223-230. doi:10.1016/0005-2736(86)90168-9
95	Rauch, J., Tannenbaum, M., Tannenbaum, H., Ramelson, H., Cullis, P. R., Tilcock, C. P. S., Hope, M. J., & Janoff, A. S. (1986). Hybridoma Lupus Anticoagulants Distinguish between Bilayer and Nonbilayer Phase Lipid Systems. Annals of the New York Academy of Sciences, 475(1), 366-369. doi:10.1111/j.1749-6632.1986.tb20896.x
94	Rauch, J., Tannenbaum, M., Tannenbaum, H., Ramelson, H., Cullis, P. R., Tilcock, C. P. S., Hope, M. J., & Janoff, A. S. (1986). Human hybridoma lupus anticoagulants distinguish between lamellar and hexagonal phase lipid systems. Journal of Biological Chemistry, 261(21), 9672-9677. Retrieved from http://www.jbc.org/content/261/21/9672.abstract
93	Mayer, L. D., Hope, M. J., & Cullis, P. R. (1986). Vesicles of variable sizes produced by a rapid extrusion procedure. Biochimica et biophysica acta, 858(1), 161-168. doi:10.1016/0005-2736(86)90302-0
92	Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1986). Techniques for encapsulating bioactive agents into liposomes. Chemistry and Physics of Lipids, 40(2-4), 333-345. doi:10.1016/0009-3084(86)90077-0
91	Mayer, L. D., Bally, M. B., & Cullis, P. R. (1986). Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochimica et biophysica acta, 857(1), 123-126. doi:10.1016/0005-2736(86)90105-7
90	Hope, M. J., Bally, M. B., Mayer, L. D., Janoff, A. S., & Cullis, P. R. (1986). Generation of multilamellar and unilamellar phospholipid vesicles. Chemistry and Physics of Lipids, 40(2), 89-107. doi:10.1016/0009-3084(86)90065-4
89	Cullis, P. R., Hope, M. J., & Tilcock, C. P. S. (1986). Lipid polymorphism and the roles of lipids in membranes. Chemistry and Physics of Lipids, 40(2), 127-144. doi:10.1016/0009-3084(86)90067-8
88	Cullis, P. R., De Kruijff, B., Verkleij, A. J., & Hope, M. J. (1986). Lipid polymorphism and membrane fusion. Biochemical Society Transactions, 14(2), 242-245. doi:10.1042/bst0140242
87	Zhang, Y. Z., Capaldi, R. A., Cullis, P. R., & Madden, T. D. (1985). Orientation of cytochrome c oxidase molecules in the two populations of reconstituted vesicles resolved by column chromatography on DEAE-Sephacryl. Biochimica et biophysica acta, 808(1), 209-211. doi:10.1016/0005-2728(85)90045-3
86	Verkleij, A. J., Van Venetië, R., Leunissen-Bijvelt, J., De Kruijff, B., Hope, M., & Cullis, P. R. (1985). Membrane Fusion and Lipid Polymorphism. In F. Conti, W. E. Blumberg, J. de Gier, & F. Pocchiari (Eds.), Physical Methods on Biological Membranes and Their Model Systems (pp. 179-192). Boston, MA: Springer US
85	Mayer, L. D., Hope, M. J., Cullis, P. R., & Janoff, A. S. (1985). Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochimica et biophysica acta, 817(1), 193-196. doi:10.1016/0005-2736(85)90084-7
84	Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1985). Uptake of dibucaine into large unilamellar vesicles in response to a membrane potential. Journal of Biological Chemistry, 260(2), 802-808
83	Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1985). Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential. Biochimica et biophysica acta, 816(2), 294-302. doi:10.1016/0005-2736(85)90497-3
82	Madden, T. D., & Cullis, P. R. (1985). Preparation of reconstituted cytochrome oxidase vesicles with defined trans-membrane protein orientations employing a cytochrome c affinity column. Biochimica et biophysica acta, 808(2), 219-224. doi:10.1016/0005-2728(85)90002-7
81	Madden, T. D., Bally, M. B., Hope, M. J., Cullis, P. R., Schieren, H. P., & Janoff, A. S. (1985). Protection of large unilamellar vesicles by trehalose during dehydration: retention of vesicle contents. Biochimica et biophysica acta, 817(1), 67-74. doi:10.1016/0005-2736(85)90069-0
80	Hope, M. J., Bally, M. B., Webb, G., & Cullis, P. R. (1985). Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochimica et biophysica acta, 812(1), 55-65. doi:10.1016/0005-2736(85)90521-8
79	Gruner, S. M., Cullis, P. R., Hope, M. J., & Tilcock, C. P. S. (1985). Lipid Polymorphism: The Molecular Basis of Nonbilayer Phases. Annual Review of Biophysics and Biophysical Chemistry, 14(1), 211-238. doi:10.1146/annurev.bb.14.060185.001235
78	De Kruijff, B., Cullis, P. R., Verkleij, A. J., Hope, M. J., Van Echteld, C. J. A., & Taraschi, T. F. (1985). Lipid Polymorphism and Membrane Function. In A. N. Martonosi (Ed.), The Enzymes of Biological Membranes: Membrane Structure and Dynamics (Vol. 1, pp. 131-204). Boston, MA: Springer US
77	Cullis, P. R., Hope, M. J., & Taraschi, T. F. (1985). Modulation of lipid polymorphism by lipid-protein interactions. Progress in protein-lipid interactions, 1, 89-142
76	Cullis, P. R., Hope, M. J., Nayar, R., & Tilcock, C. P. S. (1985). Roles of Phospholipids in Exocytosis (G. B. Ansell, G. Porcellati, & L. A. Horrocks Eds.). New York: Raven Press
75	Cullis, P. R., Hope, M. J., Nayar, R., Bally, M. B., & Tilcock, C. P. S. (1985). Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure (G. B. Ansell, G. Porcellati, & L. A. Horrocks Eds.). Vol. 2: Physiological Roles
74	Cullis, P. R., Hope, M. J., De Kruijff, B., Verkleij, A. J., & Tilcock, C. P. S. (1985). Structural Properties and Functional Roles of Phospholipids in Membranes. In Phospholipids and Cellular Regulation. Boca Raton: CRC Press.
73	Cullis, P. R., & Hope, M. J. (1985). Physical Properties and Functional Roles of Lipids in Membranes (D. E. Vance & J. E. Vance Eds.). Menlo Park: Benjamin/Cummings
72	Bally, M. B., Hope, M. J., Van Echteld, C. J. A., & Cullis, P. R. (1985). Uptake of safranine and other lipophilic cations into model membrane systems in response to a membrane potential. Biochimica et biophysica acta, 812(1), 66-76. doi:10.1016/0005-2736(85)90522-X
71	Verkleij, A. J., Leunissen-Bijvelt, L., De Kruijff, B., Hope, M. J., & Cullis, P. R. (1984). Non-Bilayer Structures in Membrane Fusion. In Ciba Foundation Symposium ‐ Cell Fusion (Vol. 103, pp. 45-59)
70	Tilcock, C. P. S., Hope, M. J., & Cullis, P. R. (1984). Influence of cholesterol esters of varying unsaturation on the polymorphic phase preferences of egg phosphatidylethanolamine. Chemistry and Physics of Lipids, 35(4), 363-370. doi:10.1016/0009-3084(84)90078-1
69	Tilcock, C. P. S., Bally, M. B., Farren, S. B., Cullis, P. R., & Gruner, S. M. (1984). Cation-dependent segregation phenomena and phase behavior in model membrane systems containing phosphatidylserine: influence of cholesterol and acyl chain composition. Biochemistry, 23(12), 2696-2703. doi:10.1021/bi00307a025
68	Sommerman, E. F., Pritchard, P. H., & Cullis, P. R. (1984). 125I labelled inulin: a convenient marker for deposition of liposomal contents in vivo. Biochemical and Biophysical Research Communications, 122(1), 319-324. doi:10.1016/0006-291x(84)90477-7
67	Nayar, R., Mayer, L. D., Hope, M. J., & Cullis, P. R. (1984). Phosphatidic acid as a calcium ionophore in large unilamellar vesicle systems. Biochimica et biophysica acta, 777(2), 343-346. doi:10.1016/0005-2736(84)90438-3
66	Madden, T. D., Hope, M. J., & Cullis, P. R. (1984). Influence of vesicle size and oxidase content on respiratory control in reconstituted cytochrome oxidase vesicles. Biochemistry, 23(7), 1413-1418. doi:10.1021/bi00302a012
65	Madden, T. D., & Cullis, P. R. (1984). Detergent-induced solubilization of cytochrome c oxidase as detected in a novel reconstituted system. Journal of Biological Chemistry, 259(12), 7655-7658
64	Farren, S. B., Sommerman, E., & Cullis, P. R. (1984). Production of specifically deuterium labelled dioleoyl phospholipid species in gram quantities: A convenient synthesis of [C[11-2H2]oleic acid. Chemistry and Physics of Lipids, 34(3), 279-286. doi:10.1016/0009-3084(84)90062-8
63	Madden, T. D., Hope, M. J., & Cullis, P. R. (1983). Lipid requirements for coupled cytochrome oxidase vesicles. Biochemistry, 22(8), 1970-1974. doi:10.1021/bi00277a036
62	Hope, M. J., Walker, D. C., & Cullis, P. R. (1983). Ca2+ and pH induced fusion of small unilamellar vesicles consisting of phosphatidylethanolamine and negatively charged phospholipids: a freeze fracture study. Biochemical and Biophysical Research Communications, 110(1), 15-22. doi:10.1016/0006-291x(83)91253-6
61	Farren, S. B., Hope, M. J., & Cullis, P. R. (1983). Polymorphic phase preferences of phosphatidic acid: A 31P and 2H NMR study. Biochemical and Biophysical Research Communications, 111(2), 675-682. doi:10.1016/0006-291x(83)90359-5
60	Cullis, P. R., De Kruijff, B., Hope, M. J., Verkleij, A. J., Nayar, R., Farren, S. B., Tilcock, C. P. S., Madden, T. D., & Bally, M. B. (1983). Structural Properties of Lipids and Their Functional Roles in Biological Membranes. In R. C. Aloia (Ed.), Concepts of Membrane Structure (pp. 39-81). New York: Academic Press.
59	Bally, M. B., Tilcock, C. P. S., Hope, M. J., & Cullis, P. R. (1983). Polymorphism of phosphatidylethanolamine-phosphatidylserine model systems: influence of cholesterol and Mg2+ on Ca2+-triggered bilayer to hexagonal (HII) transitions. Canadian Journal of Biochemistry and Cell Biology, 61, 346-352
58	Tilcock, C. P. S., & Cullis, P. R. (1982). The polymorphic phase behaviour and miscibility properties of synthetic phosphatidylethanolamines. Biochimica et biophysica acta, 684(2), 212-218. doi:10.1016/0005-2736(82)90008-6
57	Tilcock, C. P. S., Bally, M. B., Farren, S. B., & Cullis, P. R. (1982). Influence of cholesterol on the structural preferences of dioleoylphosphatidylethanolamine-dioleoylphosphatidylcholine systems: a phosphorus-31 and deuterium nuclear magnetic resonance study. Biochemistry, 21(19), 4596-4601. doi:10.1021/bi00262a013
56	Nayar, R., Schmid, S. L., Hope, M. J., & Cullis, P. R. (1982). Structural preferences of phosphatidylinositol and phosphatidylinositol-phosphatidylethanolamine model membranes. Influence of Ca2+ and Mg2+. Biochimica et biophysica acta, 688(1), 169-176. doi:10.1016/0005-2736(82)90592-2
55	Nayar, R., Hope, M. J., & Cullis, P. R. (1982). Phospholipids as adjuncts for calcium ion stimulated release of chromaffin granule contents: implications for mechanisms of exocytosis. Biochemistry, 21(19), 4583-4589. doi:10.1021/bi00262a011
54	Madden, T. D., & Cullis, P. R. (1982). Stabilization of bilayer structure for unsaturated phosphatidylethanolamines by detergents. Biochimica et biophysica acta, 684(1), 149-153. doi:10.1016/0005-2736(82)90061-X
53	Hemminga, M. A., & Cullis, P. R. (1982). 31P NMR studies of oriented phospholipid multilayers. Journal of Magnetic Resonance (1969), 47(2), 307-323. doi:10.1016/0022-2364(82)90122-6
52	De Kruijff, B., Nayar, R., & Cullis, P. R. (1982). 31P-NMR studies on phospholipid structure in membranes of intact, functionally-active, rat liver mitochondria. Biochimica et biophysica acta, 684(1), 47-52. doi:10.1016/0005-2736(82)90047-5
51	De Kruijff, B., Cullis, P. R., & Verkleij, A. J. (1982). Structural and Functional Aspects of Nonbilayer Lipids. In A. N. Martonosi (Ed.), Membranes and Transport: Volume 1 (pp. 43-49). Boston, MA: Springer US
50	Tilcock, C. P. S., & Cullis, P. R. (1981). The polymorphic phase behavior of mixed phosphatidylserine-phosphatidylethanolamine model systems as detected by 31P-NMR. Effects of divalent cations and pH. Biochimica et biophysica acta, 641(1), 189-201. doi:10.1016/0005-2736(81)90583-6
49	Hornby, A. P., & Cullis, P. R. (1981). Influence of local and neutral anaesthetics on the polymorphic phase preferences of egg yolk phosphatidylethanolamine. Biochimica et biophysica acta, 647(2), 285-292. doi:10.1016/0005-2736(81)90256-X
48	Hope, M. J., & Cullis, P. R. (1981). The role of nonbilayer lipid structures in the fusion of human erythrocytes induced by lipid fusogens. Biochimica et Biophysica Acta 640(1), 82-90. doi:10.1016/0005-2736(81)90533-2
47	De Kruijff, B., Verkleij, A. J., V an Echteld, C. J. A., Gerritsen, W. J., Noordam, P. C., Mombers, C., Rietveld, A., de Gier, J., Cullis, P. R., Hope, M. J., & Nayar, R. (1981). Non-bilayer Lipids and the Inner Mitochondrial Membrane. In H. G. Schweiger (Ed.), International Cell Biology 1980–1981: Papers Presented at the Second International Congress on Cell Biology Berlin (West), August 31 – September 5, 1980 (pp. 559-571). Berlin, Heidelberg: Springer Berlin Heidelberg
46	De Kruijff, B., Verkleij, A. J., Van Echteld, C. J. A., De Gier, J., & Cullis, P. R. (1981). Lipid Polymorphism and the Occurrence of Non-Bilayer Phases in Model and Biological Membranes, 1981 (B. e. al. Ed.): North Holland Publishing Co
45	Cullis, P. R., Farren, S. B., & Hope, M. J. (1981). 31P NMR Techniques and Membrane Lipid Structure: Implications for Mechanisms of Membrane Fusion. Canadian Journal of Spectroscopy, 26, 89-94
44	Cullis, P. R. (1981). Chapter 4 - The Lipid Bilayer, Mechanisms of Fusion and Transmembrane Transport. In S. Wolf & A. K. Murray (Eds.), Advances in Experimental Medicine and Biology - Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases (Vol. 140, pp. 137-186). New York: Plenum Press.
43	Verkleij, A. J., Van Echteld, C. J. A., Gerritsen, W. J., Cullis, P. R., & De Kruijff, B. (1980). The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions. Biochimica et biophysica acta, 600(3), 620-624. doi:10.1016/0005-2736(80)90465-4
42	Hope, M. J., & Cullis, P. R. (1980). Effects of divalent cations and pH on phosphatidylserine model membranes: A 31P NMR study. Biochemical and Biophysical Research Communications, 92(3), 846-852. doi:10.1016/0006-291X(80)90780-9
41	Farren, S. B., & Cullis, P. R. (1980). Polymorphism of phosphatidylglycerol-phosphatidylethanolamine model membrane systems: A 31P NMR study. Biochemical and Biophysical Research Communications, 97(1), 182-191. doi:10.1016/S0006-291X(80)80152-5
40	De Kruijff, B., Rietveld, A., & Cullis, P. R. (1980). 31P-NMR studies on membrane phospholipids in microsomes, rat liver slices and intact perfused rat liver. Biochimica et Biophysica Acta 600(2), 343-357. doi:10.1016/0005-2736(80)90438-1
39	De Kruijff, B., Morris, G. A., & Cullis, P. R. (1980). Application of 31P-NMR saturation transfer techniques to investigate phospholipid motion and organization in model and biological membranes. Biochimica et biophysica acta, 598(1), 206-211. doi:10.1016/0005-2736(80)90281-3
38	De Kruijff, B., Cullis, P. R., Verkleij, A. J., Vanechteld, C. J. A., Gerritsen, W. J., Mombers, C., Noordam, P. C., & Gier, J. D. (1980). Structural and functional roles of lipids in model and biological-membranes. European Journal of Cell Biology, 22(1), 217
37	De Kruijff, B., Cullis, P. R., & Verkleij, A. J. (1980). Non-bilayer lipid structures in model and biological membranes. Trends in Biochemical Sciences, 5(3), 79-81. doi:10.1016/0968-0004(80)90074-2
36	De Kruijff, B., & Cullis, P. R. (1980). The influence of poly(l-lysine) on phospholipid polymorphism - Evidence that electrostatic polypeptide-phospholipid interactions can modulate bilayer/non-bilayer transitions. Biochimica et biophysica acta, 601, 235-240. doi:10.1016/0005-2736(80)90528-3
35	De Kruijff, B., & Cullis, P. R. (1980). Cytochrome c specifically induces non-bilayer structures in cardiolipin-containing model membranes. Biochimica et biophysica acta, 602(3), 477-490. doi:10.1016/0005-2736(80)90327-2
34	Cullis, P. R., De Kruijff, B., Hope, M. J., Nayar, R., & Schmid, S. L. (1980). Phospholipids and membrane transport. Canadian Journal of Biochemistry, 58(10), 1091-1100. doi:10.1139/o80-147
33	Cullis, P. R., Hornby, A. P., & Hope, M. J. (1980). Effects of Anesthetics on Lipid Polymorphism (B. R. Fink Ed. Vol. 2: Progress in Anaesthesiology). New York: Raven Press
32	Cullis, P. R., & Hope, M. J. (1980). The bilayer stabilizing role of sphingomyelin in the presence of cholesterol. A 31P NMR study. Biochimica et biophysica acta, 597(3), 533-542. doi:10.1016/0005-2736(80)90225-4
31	Cullis, P. R., De Kruijff, B., Hope, M. J., Nayar, R., Rietveld, A., & Verkleij, A. J. (1980). Structural properties of phospholipids in the rat liver inner mitochondrial membrane. A 31P-NMR study. Biochimica et biophysica acta, 600(3), 625-635. doi:10.1016/0005-2736(80)90466-6
30	Burnell, E. E., Cullis, P. R., & De Kruijff, B. (1980). Effects of tumbling and lateral diffusion on phosphatidylcholine model membrane 31P-NMR lineshapes. Biochimica et biophysica acta, 603(1), 63-69. doi:10.1016/0005-2736(80)90391-0
29	Verkleij, A. J., Mombers, C., Gerritsen, W. J., Leunissen-Bijvelt, L., & Cullis, P. R. (1979). Fusion of phospholipid vesicles in association with the appearance of lipidic particles as visualized by freeze fracturing. Biochimica et Biophysica Acta (BBA) - Biomembranes, 555(2), 358-361. doi:10.1016/0005-2736(79)90175-5
28	Hope, M. J., & Cullis, P. R. (1979). The bilayer stability of inner monolayer lipids from the human erythrocyte. FEBS Letters, 107(2), 323-326. doi:10.1016/0014-5793(79)80399-3
27	Cullis, P. R., & Verkleij, A. J. (1979). Modulation of membrane structure by Ca2+ and dibucaine as detected by 31P NMR. Biochimica et Biophysica Acta, 552(3), 546-551. doi:10.1016/0005-2736(79)90200-1
26	Cullis, P. R., & De Kruijff, B. (1979). Lipid polymorphism and the functional roles of lipids in biological membranes. Biochimica et Biophysica Acta, 559(4), 399-420. doi:10.1016/0304-4157(79)90012-1
25	De Kruijff, B., van den Besselaar, A. M., Cullis, P. R., van den Bosch, H., & van Deenen, L. L. (1978). Evidence for isotropic motion of phospholipids in liver microsomal membranes. A 31P NMR study. Biochimica et Biophysica Acta, 514(1), 1-8. doi:10.1016/0005-2736(78)90072-x
24	Cullis, P. R., Verkleij, A. J., & Ververgaert, P. H. J. T. (1978). Polymorphic phase behaviour of cardiolipin as detected by 31P NMR and freeze-fracture techniques. Effects of calcium, dibucaine and chlorpromazine. Biochimica et Biophysica Acta (BBA), 513(1), 11-20. doi:10.1016/0005-2736(78)90107-4
23	Cullis, P. R., Van Dijck, P. W. M., De Kruijff, B., & De Gier, J. (1978). Effects of cholesterol on the properties of equimolar mixtures of synthetic phosphatidylethanolamine and phosphatidylcholine. A 31P NMR and differential scanning calorimetry study. Biochimica et Biophysica Acta, 513(1), 21-30. doi:10.1016/0005-2736(78)90108-6
22	Cullis, P. R., & Hope, M. J. (1978). Effects of fusogenic agent on membrane structure of erythrocyte ghosts and the mechanism of membrane fusion. Nature, 271(5646), 672-674. doi:10.1038/271672a0
21	Cullis, P. R., & De Kruijff, B. (1978). The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study. Biochimica et Biophysica Acta, 513(1), 31-42. doi:10.1016/0005-2736(78)90109-8
20	Cullis, P. R., & De Kruijff, B. (1978). Polymorphic phase behaviour of lipid mixtures as detected by 31P NMR. Evidence that cholesterol may destabilize bilayer structure in membrane systems containing phosphatidylethanolamine. Biochimica et Biophysica Acta, 507(2), 207-218. doi:10.1016/0005-2736(78)90417-0
19	Sim, E., & Cullis, P. R. (1977). 31P Nuclear magnetic resonance studies of cell membranes labelled with phosphonium phosphatidylcholine. FEBS Letters, 79(2), 340-344. doi:10.1016/0014-5793(77)80816-8
18	McLaughlin, A. C., Cullis, P. R., Hemminga, M. A., Brown, F. F., & Brocklehurst, J. (1977). Magnetic Resonance Studies of Model and Biological Membranes (R. A. Dwek, I. D. Campbell, R. E. Richards, & R. J. P. Williams Eds.): Academic Press
17	Cullis, P. R., & McLaughlin, A. C. (1977). Phosphorus nuclear magnetic resonance studies of model and biological membranes. Trends in Biochemical Sciences, 2(9), 196-199.
16	Cullis, P. R., & Grathwohl, C. (1977). Hydrocarbon phase transitions and lipid-protein interactions in the erythrocyte membrane. A 31P NMR and fluorescence study. Biochimica et Biophysica Acta, 471(2), 213-226. doi:10.1016/0005-2736(77)90251-6
15	Cullis, P. R., De Kruijff, B., McGrath, A. E., Morgan, C. G., & Radda, G. K. (1977). Lipid Asymmetry, Clustering and Molecular Motion in Biological Membranes and Their Models. In S. Abrahamsson & I. Pascher (Eds.), Structure of Biological Membranes (pp. 389-407). Boston, MA: Springer US
14	De Kruijff, B., Cullis, P. R., Radda, G. K., & Richards, R. E. (1976). Phosphorus nuclear magnetic resonance of Acholeplasma laidlawii cell membranes and derived liposomes. Biochimica et Biophysica Acta, 419(3), 411-424. doi:10.1016/0005-2736(76)90255-8
13	De Kruijff, B., Cullis, P. R., & Radda, G. K. (1976). Outside-inside distributions and sizes of mixed phosphatidylcholine-cholesterol vesicles. Biochimica et Biophysica Acta, 436(4), 729-740. doi:10.1016/0005-2736(76)90402-8
12	Cullis, P. R., De Kruyff, B., & Richards, R. E. (1976). Factors affecting the motion of the polar headgroup in phospholipid bilayers. A 31P NMR study of unsonicated phosphatidylcholine liposomes. Biochimica et Biophysica Acta, 426(3), 433-446. doi:10.1016/0005-2736(76)90388-6
11	Cullis, P. R., & De Kruyff, B. (1976). 31P NMR studies of unsonicated aqueous dispersions of neutral and acidic phospholipids. Effects of phase transitions, p2H and divalent cations on the motion in the phosphate region of the polar headgroup. Biochimica et Biophysica Acta, 436(3), 523-540. doi:10.1016/0005-2736(76)90438-7
10	Cullis, P. R. (1976). Lateral diffusion rates of phosphatidylcholine in vesicle membranes: Effects of cholesterol and hydrocarbon phase transitions. FEBS Letters, 70(1), 223-228. doi:10.1016/0014-5793(76)80762-4
9	Cullis, P. R. (1976). Hydrocarbon phase transitions, heterogeneous lipid distributions and lipid—protein interactions in erythrocyte membranes. FEBS Letters, 68(2), 173-176. doi:10.1016/0014-5793(76)80430-9
8	Cullis, P. R. (1976). Electron paramagnetic resonance in inhomogeneously broadened systems: A spin temperature approach. Journal of Magnetic Resonance (1969), 21(3), 397-418. doi:10.1016/0022-2364(76)90044-5
7	Sim, E., Cullis, P. R., & Richards, R. E. (1975). Physical studies on phosphonium phosphatidylcholine. A unique [31P]phosphorus nuclear-magnetic-resonance probe for model and biological membranes. The Biochemical Journal, 151(3), 555-560. doi:10.1042/bj1510555
6	McLaughlin, A. C., Cullis, P. R., Hemminga, M. A., Hoult, D. I., Radda, G. K., Ritchie, G. A., Seeley, P. J., & Richards, R. E. (1975). Application of 31P NMR to model and biological membrane systems. FEBS Letters, 57(2), 213-218. doi:10.1016/0014-5793(75)80719-8
5	McLaughlin, A. C., Cullis, P. R., Berden, J. A., & Richards, R. E. (1975). 31P NMR of Phospholipid membranes: Effects of chemical and anisotropy at high magnetic field strengths. Journal of Magnetic Resonance (1969), 20(1), 146-165. doi:10.1016/0022-2364(75)90162-6
4	De Kruijff, B., Cullis, P. R., & Radda, G. K. (1975). Differential scanning calorimetry and 31P NMR studies on sonicated and unsonicated phosphatidylcholine liposomes. Biochimica et Biophysica Acta, 406(1), 6-20. doi:10.1016/0005-2736(75)90038-3
3	Cullis, P. R., & Marko, J. R. (1975). Electron paramagnetic resonance properties of n-type silicon in the intermediate impurity-concentration range. Physical Review B, 11(11), 4184-4200. doi:10.1103/PhysRevB.11.4184
2	Berden, J. A., Cullis, P. R., Hoult, D. I., McLaughlin, A. C., Radda, G. K., & Richards, R. E. (1974). Frequency dependence of 31P NMR linewidths in sonicated phospholipid vesicles: Effects of chemical shift anisotropy. FEBS Letters, 46(1), 55-58. doi:10.1016/0014-5793(74)80333-9
1	Cullis, P. R., & Marko, J. R. (1970). Determination of the Donor Pair Exchange Energy in Phosphorus-Doped Silicon. Physical Review B, 1(2), 632-637. doi:10.1103/PhysRevB.1.632