All Publications
Sorted in chronological order and then in alphabetical order, shown in reverse order.
Last Updated: October 2024
| # | Citation | |
| 415 | Zhao, B., Kamanzi, A., Zhang, Y., Chan, K. Y. T., Robertson, M., Leslie, S., & Cullis, P. R. (2024). Determination of the interior pH of lipid nanoparticles using a pH-sensitive fluorescent dye-based DNA probe. Biosensors and Bioelectronics, 251, 116065. doi:10.1016/j.bios.2024.116065 |
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| 414 | Tafech, B., Rokhforouz, M.-R., Leung, J., Sung, M. M. H., Lin, P. J. C., Sin, D. D., Lauster, D., Block, S., Quon, B. S., Tam, Y., Cullis, P. R., Feng, J. J., & Hedtrich, S. (2024). Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions. Advanced Healthcare Materials, 2304525. doi:10.1002/adhm.202304525 |
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| 413 | Strong, C., Leung, J., Kang, E., Badior, K. E., Robertson, M., Pereyra, N., Rowe, E., Wietrzny, A., Ma, B., Noronha, Z., Arnold, D., Ciufolini, M. A., Devine, D. V., Jan, E., Cullis, P. R., & Kastrup, C. J. (2024). Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices. Blood. doi:10.1182/blood.2024024405 | |
| 412 | Strilchuk, A. W., Hur, W. S., Batty, P., Sang, Y., Abrahams, S. R., Yong, A. S. M., Leung, J., Silva, L. M., Schroeder, J. A., Nesbitt, K., de Laat, B., Moutsopoulos, N. M., Bugge, T. H., Shi, Q., Cullis, P. R., Merricks, E. P., Wolberg, A. S., Flick, M. J., Lillicrap, D., Nichols, T. C., & Kastrup, C. J. (2024). Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A. Science Translational Medicine, 16(735), eadh0027. doi:10.1126/scitranslmed.adh0027 |
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| 411 | Short, L., Holt, R. A., Cullis, P. R., & Evgin, L. (2024). Direct in vivo CAR T cell engineering. Trends in Pharmacological Sciences, 45(5), 406-418. doi:10.1016/j.tips.2024.03.004 |
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| 410 | Leung, J., Primbetova, A., Strong, C., Hay, B. N., Hsu, H. H., Hagner, A., Foster, L. J., Devine, D., Cullis, P. R., Zandstra, P. W., & Kastrup, C. J. (2024). Genetic engineering of megakaryocytes from blood progenitor cells using mRNA lipid nanoparticles. Journal of Thrombosis and Haemostasis. doi:10.1016/j.jtha.2024.09.008 | |
| 409 | Kamanzi, A., Zhang, Y., Gu, Y. F., Liu, F., Berti, R., Wang, B., Saadati, F., Ciufolini, M. A., Kulkarni, J., Cullis, P., & Leslie, S. (2024). Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters. ACS Nano, 18(28), 18191-18201. doi:10.1021/acsnano.3c12981 |
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| 408 | Francia, V., Zhang, Y., Cheng, M. H. Y., Schiffelers, R. M., Witzigmann, D., & Cullis, P. R. (2024). A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles. Proceedings of the National Academy of Sciences, 121(11), e2307803120. doi:10.1073/pnas.2307803120 |
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| 407 | Ferraresso, F., Badior, K., Seadler, M., Zhang, Y., Wietrzny, A., Cau, M. F., Haugen, A., Rodriguez, G. G., Dyer, M. R., Cullis, P. R., Jan, E., & Kastrup, C. J. (2024). Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine. Molecular Therapy - Methods & Clinical Development, 101314. doi:10.1016/j.omtm.2024.101314 |
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| 406 | Cullis, P. R., & Felgner, P. L. (2024). The 60-year evolution of lipid nanoparticles for nucleic acid delivery. Nature Reviews Drug Discovery. doi:10.1038/s41573-024-00977-6 |
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| 405 | Cau, M. F., Ferraresso, F., Seadler, M., Badior, K., Zhang, Y., Ketelboeter, L. M., Rodriguez, G. G., Chen, T., Ferraresso, M., Wietrzny, A., Robertson, M., Haugen, A., Cullis, P. R., de Moya, M., Dyer, M., & Kastrup, C. J. (2024). siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles. Molecular Therapy Methods & Clinical Development, 32(2). doi:10.1016/j.omtm.2024.101258 |
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| 404 | Anwar, M. A., Keshteli, A. H., H., Y., Wang, W., Li, X., Messier, H. M., Cullis, P. R., Borchers, C. H., Fraser, R., & Wishart, D. S. (2024). Blood-Based Multiomics-Guided Detection of a Precancerous Pancreatic Tumor. OMICS: A Journal of Integrative Biology, 28(4), 182-192. doi:omi.2023.0278 |
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| 403 | Zhigaltsev, I. V., & Cullis, P. R. (2023). Morphological Behavior of Liposomes and Lipid Nanoparticles. Langmuir, 39(9), 3185-3193. doi:10.1021/acs.langmuir.2c02794 |
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| 402 | Uzel, A., Agiotis, L., Baron, A., Zhigaltsev, I. V., Cullis, P. R., Hasanzadeh Kafshgari, M., & Meunier, M. (2023). Single Pulse Nanosecond Laser-Stimulated Targeted Delivery of Anti-Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles. Small, 19(52), 2305591. doi:10.1002/smll.202305591 |
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| 401 | Mo, Y., Cheng, M. H. Y., D’Elia, A., Doran, K., Ding, L., Chen, J., Cullis, P. R., & Zheng, G. (2023). Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles. ACS Nano, 17(5), 4688-4703. doi:10.1021/acsnano.2c10936 |
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| 400 | Meulewaeter, S., Zhang, Y., Wadhwa, A., Fox, K., Lentacker, I., Harder, K. W., Cullis, P. R., De Smedt, S. C., H. Y. Cheng, M., & Verbeke, R. (2023). Considerations on the design of lipid-based mRNA vaccines against cancer. Journal of Molecular Biology, 168385. doi:10.1016/j.jmb.2023.168385 |
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| 399 | Meulewaeter, S., Nuytten, G., Cheng, M. H. Y., De Smedt, S. C., Cullis, P. R., De Beer, T., Lentacker, I., & Verbeke, R. (2023). Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures. Journal of Controlled Release, 357, 149-160. doi:10.1016/j.jconrel.2023.03.039 |
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| 398 | Leung, J., Strong, C., Badior, K. E., Robertson, M. K., Wu, X., Meledeo, M. A., Kang, E., Paul, M., Sato, Y., Harashima, H., Cap, A. P., Devine, D. V., Jan, E., Cullis, P. R., & Kastrup, C. J. (2023). Genetically engineered transfusable platelets using mRNA lipid nanoparticles. Science Advances, 9(48), eadi0508. doi:10.1126/sciadv.adi0508 |
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| 397 | Cheng, M. H. Y., Leung, J., Zhang, Y., Strong, C., Basha, G., Momeni, A., Chen, Y., Jan, E., Abdolahzadeh, A., Wang, X., Kulkarni, J. A., Witzigmann, D., & Cullis, P. R. (2023). Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency. Advanced Materials, 35(31), 2303370. doi:10.1002/adma.202303370 |
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| 396 | Chander, N., Basha, G., Cheng, M. H. Y., Witzigmann, D., & Cullis, P. R. (2023). Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues. Molecular Therapy - Methods & Clinical Development, 30, 235-245. doi:10.1016/j.omtm.2023.06.005 |
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| 395 | Bolsoni, J., Liu, D., Mohabatpour, F., Ebner, R., Sadhnani, G., Tafech, B., Leung, J., Shanta, S., An, K., Morin, T., Chen, Y., Arguello, A., Choate, K., Jan, E., Ross, C. J. D., Brambilla, D., Witzigmann, D., Kulkarni, J., Cullis, P. R., & Hedtrich, S. (2023). Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano, 17(21), 22046-22059. doi:10.1021/acsnano.3c08644 |
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| 394 | Zhigaltsev, I. V., Tam, Y. Y. C., Kulkarni, J. A., & Cullis, P. R. (2022). Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug. Langmuir, 38(25), 7858-7866. doi:10.1021/acs.langmuir.2c01221 |
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| 393 | Tam, A., Kulkarni, J., An, K., Li, L., Dorscheid, D. R., Singhera, G. K., Bernatchez, P., Reid, G. S. D., Chan, K. Y. T., Witzigmann, D., Cullis, P. R., Sin, D. D., & Lim, C. J. (2022). Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways. European Journal of Pharmaceutical Sciences, 176, 106234. doi:10.1016/j.ejps.2022.106234 |
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| 392 | Quick, J., Dos Santos, N., Cheng, M. H. Y., Chander, N., Brimacombe, C. A., Kulkarni, J. A., van der Meel, R., Tam, Y. Y. C., Witzigmann, D., & Cullis, P. R. (2022). Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy. Journal of Controlled Release, 349, 174-183. doi:10.1016/j.jconrel.2022.06.051 |
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| 391 | Pattipeiluhu, R., Arias-Alpizar, G., Basha, G., Chan, K. Y. T., Bussmann, J., Sharp, T. H., Moradi, M.-A., Sommerdijk, N., Harris, E. N., Cullis, P. R., Kros, A., Witzigmann, D., & Campbell, F. (2022). Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System. Advanced Materials, 34(16), 2201095. doi:10.1002/adma.202201095 |
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| 390 | Labouta, H. I., Langer, R., Cullis, P. R., Merkel, O. M., Prausnitz, M. R., Gomaa, Y., Nogueira, S. S., & Kumeria, T. (2022). Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective. Drug delivery and translational research. doi:10.1007/s13346-022-01146-1 |
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| 389 | Juang, L. J., Hur, W. S., Silva, L. M., Strilchuk, A. W., Francisco, B., Leung, J., Robertson, M. K., Groeneveld, D. J., La Prairie, B., Chun, E. M., Cap, A. P., Luyendyk, J. P., Palumbo, J. S., Cullis, P. R., Bugge, T. H., Flick, M. J., & Kastrup, C. J. (2022). Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA. Blood, 139(9), 1302-1311. doi:10.1182/blood.2021014559 |
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| 388 | Cullis, P. R. (2022). Learning lessons from lipids to make COVID-19 vaccines. Cell, 185(8), 1279-1282. doi:10.1016/j.cell.2022.03.026 |
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| 387 | Cheng, M. H. Y., Brimacombe, C. A., Verbeke, R., & Cullis, P. R. (2022). Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies. Molecular Pharmaceutics, 19(6), 1663-1668. doi:10.1021/acs.molpharmaceut.2c00365 |
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| 386 | Basha, G., Cottle, A. G., Pretheeban, T., Chan, K. Y. T., Witzigmann, D., Young, R. N., Rossi, F. M. V., & Cullis, P. R. (2022). Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo. Molecular Therapy. doi:10.1016/j.ymthe.2022.06.012 |
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| 395 | An, K., Kurek, D., Mahadeo, M., Zhang, Y., Thewalt, J. L., Cullis, P. R., & Kulkarni, J. A. (2022). On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology. Langmuir, 38(46), 14036-14043. doi:10.1021/acs.langmuir.2c01492 |
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| 384 | Al Fayez, N., Rouhollahi, E., Ong, C. Y., Wu, J., Nguyen, A., Böttger, R., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2022). Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen. Journal of Controlled Release, 350, 630-641. doi:10.1016/j.jconrel.2022.08.058 |
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| 383 | Al Fayez, N., Böttger, R., Ghosh, S., Nakajima, Y., Chao, P.-H., Rouhollahi, E., Nguyen, A., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2022). Development of a child-friendly oral drug formulation using liposomal multilamellar vesicle technology. International Journal of Pharmaceutics, 625, 122107. doi:10.1016/j.ijpharm.2022.122107 |
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| 382 | Vogler, J., Böttger, R., Al Fayez, N., Zhang, W., Qin, Z., Hohenwarter, L., Chao, P.-H., Rouhollahi, E., Bilal, N., Chen, N., Lee, B., Chen, C., Wilkinson, B., Kieffer, T. J., Kulkarni, J. A., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2021). Altering the intra-liver distribution of phospholipid-free small unilamellar vesicles using temperature-dependent size-tunability. Journal of Controlled Release, 333, 151-161. doi:10.1016/j.jconrel.2021.03.025 |
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| 381 | van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R., & Tam, Y. Y. C. (2021). Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery. Small, 17(37), 2103025. doi:10.1002/smll.202103025 |
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| 380 | Terada, T., Kulkarni, J. A., Huynh, A., Tam, Y. Y. C., & Cullis, P. (2021). Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis. Biological and Pharmaceutical Bulletin, 44(1), 144-149. doi:10.1248/bpb.b20-00679 |
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| 379 | Terada, T., Kulkarni, J. A., Huynh, A., Chen, S., van der Meel, R., Tam, Y. Y. C., & Cullis, P. R. (2021). Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach. Langmuir, 37(3), 1120-1128. doi:10.1021/acs.langmuir.0c03039 |
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| 378 | Tam, A., Leclair, P., Li, L. V., Yang, C. X., Li, X., Witzigmann, D., Kulkarni, J. A., Hackett, T. L., Dorscheid, D. R., Singhera, G. K., Hogg, J. C., Cullis, P. R., Sin, D. D., & Lim, C. J. (2021). FAM13A as potential therapeutic target in modulating TGF-beta-induced airway tissue remodeling in COPD. American Journal of Physiology-Lung Cellular and Molecular Physiology. doi:10.1152/ajplung.00477.2020 |
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| 377 | Morozko, E. L., Smith-Geater, C., Monteys, A. M., Pradhan, S., Lim, R. G., Langfelder, P., Kachemov, M., Hill, A., Stocksdale, J. T., Cullis, P. R., Wu, J., Ochaba, J., Miramontes, R., Chakraborty, A., Hazra, T. K., Lau, A., St-cyr, S., Orellana, I., Kopan, L., Wang, K. Q., Yeung, S., Leavitt, B. R., Reidling, J. C., Yang, X. W., Steffan, J. S., Davidson, B. L., Sarkar, P. S., & Thompson, L. M. (2021). PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease. Proceedings of the National Academy of Sciences, 118(4), e2021836118. doi:10.1073/pnas.2021836118 |
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| 376 | Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R., & van der Meel, R. (2021). The current landscape of nucleic acid therapeutics. Nature Nanotechnology. doi:10.1038/s41565-021-00898-0 |
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| 375 | Kulkarni, J. A., Chen, S., & Tam, Y. Y. C. (2021). Scalable Production of Lipid Nanoparticles Containing Amphotericin B. Langmuir, 37(24), 7312-7319. doi:10.1021/acs.langmuir.1c00530 |
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| 374 | Kamanzi, A., Gu, Y. F., Tahvildari, R., Friedenberger, Z., Zhu, X. Q., Berti, R., Kurylowicz, M., Witzigmann, D., Kulkarni, J. A., Leung, J., Andersson, J., Dahlin, A., Höök, F., Sutton, M., Cullis, P. R., & Leslie, S. (2021). Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles. ACS Nano. doi:10.1021/acsnano.1c04862 |
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| 373 | Henrickson, A., Kulkarni, J. A., Zaifman, J., Gorbet, G. E., Cullis, P. R., & Demeler, B. (2021). Density Matching Multi-wavelength Analytical Ultracentrifugation to Measure Drug Loading of Lipid Nanoparticle Formulations. ACS Nano. doi:10.1021/acsnano.0c10069 |
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| 372 | Chander, N., Morstein, J., Bolten, J. S., Shemet, A., Cullis, P. R., Trauner, D., & Witzigmann, D. (2021). Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release. Small, 2008198. doi:10.1002/smll.202008198 |
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| 371 | Al Fayez, N., Böttger, R., Rouhollahi, E., Cullis, P. R., Witzigmann, D., & Li, S.-D. (2021). Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity. Molecular Pharmaceutics. doi:10.1021/acs.molpharmaceut.1c00520 |
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| 370 | Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020). Lipid nanoparticle technology for therapeutic gene regulation in the liver. Advanced Drug Delivery Reviews, 159, 344-363. doi:10.1016/j.addr.2020.06.026 |
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| 369 | van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R., & Tam, Y. Y. C. (2020). Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery. bioRxiv, 2020.2001.2016.907394. doi:10.1101/2020.01.16.907394 |
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| 368 | Uhl, P., Grundmann, C., Sauter, M., Storck, P., Tursch, A., Özbek, S., Leotta, K., Roth, R., Witzigmann, D., Kulkarni, J. A., Fidelj, V., Kleist, C., Cullis, P. R., Fricker, G., & Mier, W. (2020). Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide. Nanomedicine: Nanotechnology, Biology and Medicine, 24, 102132. doi:10.1016/j.nano.2019.102132 |
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| 367 | Strilchuk, A. W., Meixner, S. C., Leung, J., Safikhan, N. S., Kulkarni, J. A., Russell, H. M., van der Meel, R., Sutherland, M. R., Owens III, A. P., Palumbo, J. S., Conway, E. M., Pryzdial, E. L. G., Cullis, P. R., & Kastrup, C. J. (2020). Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. Blood, 136(25), 2946-2954. doi:10.1182/blood.2020004976 |
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| 366 | Roberts, M. E., Barvalia, M., Silva, J. A. F. D., Cederberg, R. A., Chu, W., Wong, A., Tai, D. C., Chen, S., Matos, I., Priatel, J. J., Cullis, P. R., & Harder, K. W. (2020). Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan. Circulation Research, 126(10), e61-e79. doi:10.1161/CIRCRESAHA.119.315708 |
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| 365 | Ramezanpour, M., Schmidt, M. L., Bashe, B. Y. M., Pruim, J. R., Link, M. L., Cullis, P. R., Harper, P. E., Thewalt, J. L., & Tieleman, D. P. (2020). Structural Properties of Inverted Hexagonal Phase: A Hybrid Computational and Experimental Approach. Langmuir, 36(24), 6668-6680. doi:10.1021/acs.langmuir.0c00600 |
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| 364 | Kulkarni, J. A., Thomson, S. B., Zaifman, J., Leung, J., Wagner, P. K., Hill, A., Tam, Y. Y. C., Cullis, P. R., Petkau, T. L., & Leavitt, B. R. (2020). Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles. Nanoscale, 12(47), 23959-23966. doi:10.1039/D0NR06816K |
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| 363 | Francia, V., Schiffelers, R. M., Cullis, P. R., & Witzigmann, D. (2020). The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy. Bioconjugate Chemistry, 31(9), 2046-2059. doi:10.1021/acs.bioconjchem.0c00366 |
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| 362 | Chen, K. T. J., Anantha, M., Leung, A. W. Y., Kulkarni, J. A., Militao, G. G. C., Wehbe, M., Sutherland, B., Cullis, P. R., & Bally, M. B. (2020). Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use. Drug delivery and translational research, 10(1), 202-215. doi:10.1007/s13346-019-00674-7 |
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| 361 | Anwar, M. A., Barrera-Machuca, A. A., Calderon, N., Wang, W., Tausan, D., Vayali, T., Wishart, D., Cullis, P. R., & Fraser, R. (2020). Value-based healthcare delivery through metabolomics-based personalized health platform. Healthcare Management Forum, 33(3), 126-134. doi:10.1177/0840470420904733 |
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| 360 | Zhang, W., Böttger, R., Qin, Z., Kulkarni, J. A., Vogler, J., Cullis, P. R., & Li, S.-D. (2019). Phospholipid-Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver. Small, 15(43), 1901782. doi:10.1002/smll.201901782 |
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| 359 | Ramezanpour, M., Schmidt, M. L., Bodnariuc, I., Kulkarni, J. A., Leung, S. S. W., Cullis, P. R., Thewalt, J. L., & Tieleman, D. P. (2019). Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function. Nanoscale, 11(30), 14141-14146. doi:10.1039/c9nr02297j |
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| 358 | Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thony, B., Tam, Y. Y. C., & Cullis, P. R. (2019). Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads. Nanoscale, 11(18), 9023-9031. doi:10.1039/c9nr02004g |
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| 357 | Kulkarni, J. A., Witzigmann, D., Leung, J., Tam, Y. Y. C., & Cullis, P. R. (2019). On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale, 11(45), 21733-21739. doi:10.1039/c9nr09347h |
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| 356 | Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R., & van der Meel, R. (2019). Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics. Accounts of Chemical Research, 52(9), 2435-2444. doi:10.1021/acs.accounts.9b00368 |
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| 355 | Jyotsana, N., Sharma, A., Chaturvedi, A., Budida, R., Scherr, M., Kuchenbauer, F., Lindner, R., Noyan, F., Suhs, K. W., Stangel, M., Grote-Koska, D., Brand, K., Vornlocher, H. P., Eder, M., Thol, F., Ganser, A., Humphries, R. K., Ramsay, E., Cullis, P., & Heuser, M. (2019). Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo. Annals of Hematology, 98(8), 1905-1918. doi:10.1007/s00277-019-03713-y |
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| 354 | Hamano, N., Bottger, R., Lee, S. E., Yang, Y., Kulkarni, J. A., Ip, S., Cullis, P. R., & Li, S. D. (2019). Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin. Molecular Pharmaceutics, 16(9), 3957-3967. doi:10.1021/acs.molpharmaceut.9b00583 |
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| 353 | Buck, J., Grossen, P., Cullis, P. R., Huwyler, J., & Witzigmann, D. (2019). Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery. ACS Nano, 13(4), 3754-3782. doi:10.1021/acsnano.8b07858 |
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| 352 | Bromma, K., Rieck, K., Kulkarni, J., O’Sullivan, C., Sung, W., Cullis, P., Schuemann, J., & Chithrani, D. B. (2019). Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy. Cancer Nanotechnology, 10(1), 1. doi:10.1186/s12645-019-0046-z |
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| 351 | Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., Mui, B. L., Semple, S. C., Tam, Y. K., Ciufolini, M., Witzigmann, D., Kulkarni, J. A., van der Meel, R., & Cullis, P. R. (2019). The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nature Nanotechnology, 14(12), 1084-1087. doi:10.1038/s41565-019-0591-y |
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| 350 | Tang, W. L., Tang, W. H., Szeitz, A., Kulkarni, J., Cullis, P., & Li, S. D. (2018). Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials, 166, 13-26. doi:10.1016/j.biomaterials.2018.03.004 |
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| 349 | Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., van der Meel, R., Thewalt, J. L., Tam, Y. Y. C., & Cullis, P. R. (2018). On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA. ACS Nano, 12(5), 4787-4795. doi:10.1021/acsnano.8b01516 |
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| 348 | Kulkarni, J. A., Cullis, P. R., & van der Meel, R. (2018). Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility. Nucleic Acid Therapeutics, 28(3), 146-157. doi:10.1089/nat.2018.0721 |
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| 347 | Jyotsana, N., Sharma, A., Chaturvedi, A., Scherr, M., Kuchenbauer, F., Sajti, L., Barchanski, A., Lindner, R., Noyan, F., Suhs, K. W., Grote-Koska, D., Brand, K., Vornlocher, H. P., Stanulla, M., Bornhauser, B., Bourquin, J. P., Eder, M., Thol, F., Ganser, A., Humphries, R. K., Ramsay, E., Cullis, P., & Heuser, M. (2018). RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia, 32(1), 224-226. doi:10.1038/leu.2017.269 |
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| 346 | Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018). State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery. Small Methods, 2(9), 1700375. doi:10.1002/smtd.201700375 |
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| 345 | Chen, S., Zaifman, J., Kulkarni, J. A., Zhigaltsev, I. V., Tam, Y. K., Ciufolini, M. A., Tam, Y. Y. C., & Cullis, P. R. (2018). Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids. Journal of Controlled Release, 286, 46-54. doi:10.1016/j.jconrel.2018.07.026 |
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| 344 | Cain, S. M., Tyson, J. R., Choi, H. B., Ko, R., Lin, P. J. C., LeDue, J. M., Powell, K. L., Bernier, L. P., Rungta, R. L., Yang, Y., Cullis, P. R., O'Brien, T. J., MacVicar, B. A., & Snutch, T. P. (2018). CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons. Epilepsia, 59(4), 778-791. doi:10.1111/epi.14018 |
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| 343 | Neumann, U. H., Ho, J. S. S., Chen, S., Tam, Y. Y. C., Cullis, P. R., & Kieffer, T. J. (2017). Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Molecular Metabolism, 6(10), 1161-1172. doi:10.1016/j.molmet.2017.06.012 |
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| 342 | Kulkarni, J. A., Tam, Y. Y. C., Chen, S., Tam, Y. K., Zaifman, J., Cullis, P. R., & Biswas, S. (2017). Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles. Nanoscale, 9(36), 13600-13609. doi:10.1039/c7nr03272b |
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| 341 | Kulkarni, J. A., Myhre, J. L., Chen, S., Tam, Y. Y. C., Danescu, A., Richman, J. M., & Cullis, P. R. (2017). Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine, 13(4), 1377-1387. doi:10.1016/j.nano.2016.12.014 |
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| 340 | Cullis, P. R., & Hope, M. J. (2017). Lipid Nanoparticle Systems for Enabling Gene Therapies. Molecular Therapy, 25(7), 1467-1475. doi:10.1016/j.ymthe.2017.03.013 |
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| 339 | Zhigaltsev, I. V., Tam, Y. K., Leung, A. K., & Cullis, P. R. (2016). Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents. Journal of Liposome Research, 26(2), 96-102. doi:10.3109/08982104.2015.1025411 |
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| 338 | Wang, H., Tam, Y. Y., Chen, S., Zaifman, J., van der Meel, R., Ciufolini, M. A., & Cullis, P. R. (2016). The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA. Molecular Therapy, 24(12), 2100-2108. doi:10.1038/mt.2016.179 |
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| 337 | Lee, J. B., Zhang, K., Tam, Y. Y., Quick, J., Tam, Y. K., Lin, P. J., Chen, S., Liu, Y., Nair, J. K., Zlatev, I., Rajeev, K. G., Manoharan, M., Rennie, P. S., & Cullis, P. R. (2016). A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo. Molecular Therapy: Nucleic Acids, 5, e348. doi:10.1038/mtna.2016.43 |
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| 336 | Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016). Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA. Journal of Controlled Release, 235, 236-244. doi:10.1016/j.jconrel.2016.05.059 |
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| 335 | Basha, G., Ordobadi, M., Scott, W. R., Cottle, A., Liu, Y., Wang, H., & Cullis, P. R. (2016). Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo. Molecular Therapy: Nucleic Acids, 5(9), e363. doi:10.1038/mtna.2016.68 |
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| 334 | Yamamoto, Y., Lin, P. J., Beraldi, E., Zhang, F., Kawai, Y., Leong, J., Katsumi, H., Fazli, L., Fraser, R., Cullis, P. R., & Gleave, M. (2015). siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer. Clinical Cancer Research, 21(21), 4845-4855. doi:10.1158/1078-0432.Ccr-15-0866 |
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| 333 | Rungta, R. L., Choi, H. B., Tyson, J. R., Malik, A., Dissing-Olesen, L., Lin, P. J. C., Cain, S. M., Cullis, P. R., Snutch, T. P., & MacVicar, B. A. (2015). The cellular mechanisms of neuronal swelling underlying cytotoxic edema. Cell, 161(3), 610-621. doi:10.1016/j.cell.2015.03.029 |
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| 332 | Ramishetti, S., Kedmi, R., Goldsmith, M., Leonard, F., Sprague, A. G., Godin, B., Gozin, M., Cullis, P. R., Dykxhoorn, D. M., & Peer, D. (2015). Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles. ACS Nano, 9(7), 6706-6716. doi:10.1021/acsnano.5b02796 |
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| 331 | Leung, A. K., Tam, Y. Y., Chen, S., Hafez, I. M., & Cullis, P. R. (2015). Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems. Journal of Physical Chemistry B, 119(28), 8698-8706. doi:10.1021/acs.jpcb.5b02891 |
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| 330 | Wan, C., Allen, T. M., & Cullis, P. R. (2014). Lipid nanoparticle delivery systems for siRNA-based therapeutics. Drug delivery and translational research, 4(1), 74-83. doi:10.1007/s13346-013-0161-z |
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| 329 | Walsh, C., Ou, K., Belliveau, N. M., Leaver, T. J., Wild, A. W., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Lee, J. B., Hansen, C. L., Taylor, R. J., Ramsay, E. C., & Cullis, P. R. (2014). Microfluidic-based manufacture of siRNA-lipid nanoparticles for therapeutic applications. Methods in Molecular Biology, 1141, 109-120. doi:10.1007/978-1-4939-0363-4_6 |
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| 328 | Neumann, U. H., Chen, S., Tam, Y. Y., Baker, R. K., Covey, S. D., Cullis, P. R., & Kieffer, T. J. (2014). IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology, 155(3), 716-725. doi:10.1210/en.2013-1622 |
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| 327 | Lin, P. J., Tam, Y. K., & Cullis, P. R. (2014). Development and clinical applications of siRNA-encapsulated lipid nanoparticles in cancer. Clinical Lipidology, 9(3), 317-331. doi:10.2217/clp.14.27 |
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| 326 | Leung, A. K., Tam, Y. Y., & Cullis, P. R. (2014). Lipid nanoparticles for short interfering RNA delivery. Advances in Genetics, 88, 71-110. doi:10.1016/b978-0-12-800148-6.00004-3 |
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| 325 | Fenske, D. B., & Cullis, P. R. (2014). Chapter 15 - Medical Applications of Lipid Nanoparticles. In Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application (1 ed.). Boca Raton: CRC Press. |
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| 324 | Chen, S., Tam, Y. Y., Lin, P. J., Leung, A. K., Tam, Y. K., & Cullis, P. R. (2014). Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. Journal of Controlled Release, 196, 106-112. doi:10.1016/j.jconrel.2014.09.025 |
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| 323 | Tam, Y. Y. C., Chen, S., & Cullis, P. R. (2013). Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics, 5(3), 498-507. doi:10.3390/pharmaceutics5030498 |
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| 322 | Tam, Y. Y., Chen, S., Zaifman, J., Tam, Y. K., Lin, P. J., Ansell, S., Roberge, M., Ciufolini, M. A., & Cullis, P. R. (2013). Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA. Nanomedicine, 9(5), 665-674. doi:10.1016/j.nano.2012.11.006 |
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| 321 | Rungta, R. L., Choi, H. B., Lin, P. J., Ko, R. W., Ashby, D., Nair, J., Manoharan, M., Cullis, P. R., & Macvicar, B. A. (2013). Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Molecular Therapy: Nucleic Acids, 2, e136. doi:10.1038/mtna.2013.65 |
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| 320 | Mui, B. L., Tam, Y. K., Jayaraman, M., Ansell, S. M., Du, X., Tam, Y. Y., Lin, P. J., Chen, S., Narayanannair, J. K., Rajeev, K. G., Manoharan, M., Akinc, A., Maier, M. A., Cullis, P., Madden, T. D., & Hope, M. J. (2013). Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles. Molecular Therapy: Nucleic Acids, 2, e139. doi:10.1038/mtna.2013.66 |
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| 319 | Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., Zhang, X., Wang, Q., Panesar, S., Hutabarat, R., Carioto, M., Hettinger, J., Kandasamy, P., Butler, D., Rajeev, K. G., Pang, B., Charisse, K., Fitzgerald, K., Mui, B. L., Du, X., Cullis, P., Madden, T. D., Hope, M. J., Manoharan, M., & Akinc, A. (2013). Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Molecular Therapy, 21(8), 1570-1578. doi:10.1038/mt.2013.124 |
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| 318 | Lin, P. J., Tam, Y. Y., Hafez, I., Sandhu, A., Chen, S., Ciufolini, M. A., Nabi, I. R., & Cullis, P. R. (2013). Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA. Nanomedicine, 9(2), 233-246. doi:10.1016/j.nano.2012.05.019 |
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| 317 | Allen, T. M., & Cullis, P. R. (2013). Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews, 65(1), 36-48. doi:10.1016/j.addr.2012.09.037 |
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| 316 | Zhigaltsev, I. V., Belliveau, N. M., Hafez, I., Leung, A. K. K., Huft, J., Hansen, C. L., & Cullis, P. R. (2012). Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing. Langmuir, 28(7), 3633-3640. doi:10.1021/la204833h |
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| 315 | Novobrantseva, T. I., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K., Querbes, W., Ge, P., Ruda, V. M., Milstein, S., Speciner, L., Duncan, R., Barros, S., Basha, G., Cullis, P., Akinc, A., Donahoe, J. S., Narayanannair Jayaprakash, K., Jayaraman, M., Bogorad, R. L., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, F. K., Weissleder, R., Langer, R., Anderson, D. G., de Fougerolles, A., Nahrendorf, M., & Koteliansky, V. (2012). Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular Therapy: Nucleic Acids, 1, e4. doi:10.1038/mtna.2011.3 |
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| 314 | Leung, A. K., Hafez, I. M., Baoukina, S., Belliveau, N. M., Zhigaltsev, I. V., Afshinmanesh, E., Tieleman, D. P., Hansen, C. L., Hope, M. J., & Cullis, P. R. (2012). Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core. Journal of Physical Chemistry C: Nanomaterials and Interfaces, 116(34), 18440-18450. doi:10.1021/jp303267y |
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| 313 | Lee, J. B., Zhang, K., Tam, Y. Y., Tam, Y. K., Belliveau, N. M., Sung, V. Y., Lin, P. J., LeBlanc, E., Ciufolini, M. A., Rennie, P. S., & Cullis, P. R. (2012). Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. International Journal of Cancer, 131(5), E781-E790. doi:10.1002/ijc.27361 |
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| 312 | Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., Rajeev, K. G., Hafez, I. M., Akinc, A., Maier, M. A., Tracy, M. A., Cullis, P. R., Madden, T. D., Manoharan, M., & Hope, M. J. (2012). Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angewandte Chemie International Edition in English, 51(34), 8529-8533. doi:10.1002/anie.201203263 |
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| 311 | Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., Hansen, C. L., & Cullis, P. R. (2012). Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA. Molecular Therapy: Nucleic Acids, 1, e37. doi:10.1038/mtna.2012.28 |
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| 310 | Geetha-Loganathan, P., Nimmagadda, S., Hafez, I., Fu, K., Cullis, P. R., & Richman, J. M. (2011). Development of high-concentration lipoplexes for in vivo gene function studies in vertebrate embryos. Developmental Dynamics, 240(9), 2108-2119. doi:10.1002/dvdy.22708 |
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| 309 | Basha, G., Novobrantseva, T. I., Rosin, N., Tam, Y. Y., Hafez, I. M., Wong, M. K., Sugo, T., Ruda, V. M., Qin, J., Klebanov, B., Ciufolini, M., Akinc, A., Tam, Y. K., Hope, M. J., & Cullis, P. R. (2011). Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Molecular Therapy, 19(12), 2186-2200. doi:10.1038/mt.2011.190 |
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| 308 | Zhigaltsev, I. V., Winters, G., Srinivasulu, M., Crawford, J., Wong, M., Amankwa, L., Waterhouse, D., Masin, D., Webb, M., Harasym, N., Heller, L., Bally, M. B., Ciufolini, M. A., Cullis, P. R., & Maurer, N. (2010). Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles. Journal of Controlled Release, 144(3), 332-340. doi:10.1016/j.jconrel.2010.02.029 |
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| 307 | Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W., Stebbing, D., Crosley, E. J., Yaworski, E., Hafez, I. M., Dorkin, J. R., Qin, J., Lam, K., Rajeev, K. G., Wong, K. F., Jeffs, L. B., Nechev, L., Eisenhardt, M. L., Jayaraman, M., Kazem, M., Maier, M. A., Srinivasulu, M., Weinstein, M. J., Chen, Q., Alvarez, R., Barros, S. A., De, S., Klimuk, S. K., Borland, T., Kosovrasti, V., Cantley, W. L., Tam, Y. K., Manoharan, M., Ciufolini, M. A., Tracy, M. A., de Fougerolles, A., MacLachlan, I., Cullis, P. R., Madden, T. D., & Hope, M. J. (2010). Rational design of cationic lipids for siRNA delivery. Nature Biotechnology, 28(2), 172-176. doi:10.1038/nbt.1602 |
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| 306 | de Jong, S. D., Basha, G., Wilson, K. D., Kazem, M., Cullis, P., Jefferies, W., & Tam, Y. (2010). The Immunostimulatory Activity of Unmethylated and Methylated CpG Oligodeoxynucleotide Is Dependent on Their Ability To Colocalize with TLR9 in Late Endosomes. The Journal of Immunology, 184(11), 6092-6102. doi:10.4049/jimmunol.0802442 |
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| 305 | Wilson, K. D., de Jong, S. D., Kazem, M., Lall, R., Hope, M. J., Cullis, P. R., & Tam, Y. K. (2009). The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine. Journal of Gene Medicine, 11(1), 14-25. doi:10.1002/jgm.1267 |
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| 304 | Cressman, S., Sun, Y., Maxwell, E. J., Fang, N., Chen, D. D. Y., & Cullis, P. R. (2009). Binding and Uptake of RGD-Containing Ligands to Cellular αvβ3 Integrins. International Journal of Peptide Research and Therapeutics, 15(1), 49-59. doi:10.1007/s10989-008-9163-y |
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| 303 | Cressman, S., Dobson, I., Lee, J. B., Tam, Y. Y. C., & Cullis, P. R. (2009). Synthesis of a Labeled RGD−Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. Bioconjugate Chemistry, 20(7), 1404-1411. doi:10.1021/bc900041f |
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| 302 | Chikh, G., de Jong, S. D., Sekirov, L., Raney, S. G., Kazem, M., Wilson, K. D., Cullis, P. R., Dutz, J. P., & Tam, Y. K. (2009). Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles. International Immunology, 21(7), 757-767. doi:10.1093/intimm/dxp044 |
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| 301 | Sun, Y., Cressman, S., Fang, N., Cullis, P. R., & Chen, D. D. Y. (2008). Capillary Electrophoresis Frontal Analysis for Characterization of αvβ3 Integrin Binding Interactions. Analytical Chemistry, 80(9), 3105-3111. doi:10.1021/ac701604a |
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| 300 | Raney, S. G., Wilson, K. D., Sekirov, L., Chikh, G., de Jong, S. D., Cullis, P. R., & Tam, Y. K. (2008). The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN. Journal of Drug Targeting, 16(7), 564-577. doi:10.1080/10611860802228756 |
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| 299 | Johnston, M. J., Edwards, K., Karlsson, G., & Cullis, P. R. (2008). Influence of drug-to-lipid ratio on drug release properties and liposome integrity in liposomal doxorubicin formulations. Journal of Liposome Research, 18(2), 145-157. doi:10.1080/08982100802129372 |
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| 298 | Fenske, D. B., & Cullis, P. R. (2008). Liposomal nanomedicines. Expert Opinion on Drug Delivery, 5(1), 25-44. doi:10.1517/17425247.5.1.25 |
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| 297 | Fenske, D. B., Chonn, A., & Cullis, P. R. (2008). Liposomal nanomedicines: an emerging field. Toxicologic Pathology, 36(1), 21-29. doi:10.1177/0192623307310960 |
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| 296 | Wilson, K. D., Raney, S. G., Sekirov, L., Chikh, G., de Jong, S. D., Cullis, P. R., & Tam, Y. K. (2007). Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles. International immunopharmacology, 7(8), 1064-1075. doi:10.1016/j.intimp.2007.04.002 |
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| 295 | Webb, M. S., Boman, N. L., Masin, D., Yapp, D., Ramsay, E., Chiu, G. N. C., Cullis, P. R., & Bally, M. B. (2007). A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity. Letters in Drug Design & Discovery, 4(6), 426-433. doi:10.2174/157018007781387782 |
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| 294 | Maurer, N., Zhigaltsev, I., & Cullis, P. R. (2007). Encapsulation of Nucleic Acid–Based Therapeutics. In G. Gregoriadis (Ed.), Liposome Technology: Entrapment of Drugs and Other Materials into Liposomes (3 ed., Vol. 2, pp. 131-148). Boca Raton: CRC Press. |
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| 293 | Johnston, M. J., Semple, S. C., Klimuk, S. K., Ansell, S., Maurer, N., & Cullis, P. R. (2007). Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochimica et biophysica acta, 1768(5), 1121-1127. doi:10.1016/j.bbamem.2007.01.019 |
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| 292 | Fenske, D. B., & Cullis, P. R. (2007). Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques. In G. Gregoriadis (Ed.), Liposome Technology: Entrapment of Drugs and Other Materials into Liposomes (3 ed., Vol. 2, pp. 27-50). Boca Raton: CRC Press. |
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| 291 | de Jonge, J., Leenhouts, J. M., Holtrop, M., Schoen, P., Scherrer, P., Cullis, P. R., Wilschut, J., & Huckriede, A. (2007). Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA. Biochemical Journal, 405(1), 41-49. doi:10.1042/bj20061756 |
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| 290 | de Jong, S., Chikh, G., Sekirov, L., Raney, S., Semple, S., Klimuk, S., Yuan, N., Hope, M., Cullis, P., & Tam, Y. (2007). Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. Cancer Immunology, Immunotherapy, 56(8), 1251-1264. doi:10.1007/s00262-006-0276-x |
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| 289 | Zhigaltsev, I. V., Maurer, N., Edwards, K., Karlsson, G., & Cullis, P. R. (2006). Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention. Journal of Controlled Release, 110(2), 378-386. doi:10.1016/j.jconrel.2005.10.011 |
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| 288 | Johnston, M. J., Semple, S. C., Klimuk, S. K., Edwards, K., Eisenhardt, M. L., Leng, E. C., Karlsson, G., Yanko, D., & Cullis, P. R. (2006). Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations. Biochimica et biophysica acta, 1758(1), 55-64. doi:10.1016/j.bbamem.2006.01.009 |
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| 287 | Zhigaltsev, I. V., Maurer, N., Akhong, Q. F., Leone, R., Leng, E., Wang, J., Semple, S. C., & Cullis, P. R. (2005). Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention. Journal of Controlled Release, 104(1), 103-111. doi:10.1016/j.jconrel.2005.01.010 |
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| 286 | Waterhouse, D. N., Madden, T. D., Cullis, P. R., Bally, M. B., Mayer, L. D., & Webb, M. S. (2005). Preparation, characterization, and biological analysis of liposomal formulations of vincristine. Methods in Enzymology, 391, 40-57. doi:10.1016/s0076-6879(05)91002-1 |
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| 285 | Semple, S. C., Leone, R., Wang, J., Leng, E. C., Klimuk, S. K., Eisenhardt, M. L., Yuan, Z. N., Edwards, K., Maurer, N., Hope, M. J., Cullis, P. R., & Ahkong, Q. F. (2005). Optimization and characterization of a sphingomyelin/cholesterol liposome formulation of vinorelbine with promising antitumor activity. Journal of Pharmaceutical Sciences, 94(5), 1024-1038. doi:10.1002/jps.20332 |
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| 284 | Sandhu, A. P., Lam, A. M., Fenske, D. B., Palmer, L. R., Johnston, M., & Cullis, P. R. (2005). Calcium enhances the transfection potency of stabilized plasmid-lipid particles. Analytical Biochemistry, 341(1), 156-164. doi:10.1016/j.ab.2005.02.033 |
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| 283 | Maclachlan, I., & Cullis, P. R. (2005). Diffusible-PEG-Lipid Stabilized Plasmid Lipid Particles. Advances in Genetics, 53pa, 157-188. doi:10.1016/s0065-2660(05)53006-2 |
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| 282 | Finn, J. D., Wong, T., & Cullis, P. R. (2005). Investigation of factors responsible for cell line cytoplasmic expression differences. BMC Molecular and Cell Biology, 6(1), 11. doi:10.1186/1471-2199-6-11 |
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| 281 | Finn, J., MacLachlan, I., & Cullis, P. (2005). Factors limiting autogene-based cytoplasmic expression systems. FASEB Journal, 19(6), 608-610. doi:10.1096/fj.04-2769fje |
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| 280 | Fenske, D. B., & Cullis, P. R. (2005). Entrapment of small molecules and nucleic acid-based drugs in liposomes. Methods in Enzymology, 391, 7-40. doi:10.1016/s0076-6879(05)91001-x |
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| 279 | Ambegia, E., Ansell, S., Cullis, P., Heyes, J., Palmer, L., & MacLachlan, I. (2005). Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochimica et biophysica acta, 1669(2), 155-163. doi:10.1016/j.bbamem.2005.02.001 |
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| 278 | Abraham, S. A., Waterhouse, D. N., Mayer, L. D., Cullis, P. R., Madden, T. D., & Bally, M. B. (2005). The liposomal formulation of doxorubicin. Methods in Enzymology, 391, 71-97. doi:10.1016/s0076-6879(05)91004-5 |
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| 277 | Hafez, I. M., & Cullis, P. R. (2004). Tunable pH-sensitive liposomes. Methods in Enzymology, 387, 113-134. doi:10.1016/s0076-6879(04)87007-1 |
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| 276 | Finn, J., Lee, A. C., MacLachlan, I., & Cullis, P. (2004). An enhanced autogene-based dual-promoter cytoplasmic expression system yields increased gene expression. Gene Therapy, 11(3), 276-283. doi:10.1038/sj.gt.3302172 |
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| 275 | Fenske, D. B., & Cullis, P. R. (2004). Liposomes: Models of Biological Membranes and Drug Delivery Systems. Physics in Canada, 60(2), 187-194. |
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| 274 | Chen, T., Palmer, L. R., Fenske, D. B., Lam, A. M., Wong, K. F., & Cullis, P. R. (2004). Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake. Journal of Liposome Research, 14(3-4), 155-173. doi:10.1081/lpr-200033437 |
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| 273 | Chen, T., McIntosh, D., He, Y. H., Kim, J. S., Tirrell, D. A., Scherrer, P., Fenske, D. B., Sandhu, A. P., & Cullis, P. R. (2004). Alkylated derivatives of poly(ethylacrylic acid) can be inserted into preformed liposomes and trigger pH-dependent intracellular delivery of liposomal contents. Molecular Membrane Biology, 21(6), 385-393. doi:10.1080/09687860400010516 |
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| 272 | Allen, T. M., & Cullis, P. R. (2004). Drug delivery systems: entering the mainstream. Science, 303(5665), 1818-1822. doi:10.1126/science.1095833 |
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| 271 | Palmer, L. R., Chen, T., Lam, A. M., Fenske, D. B., Wong, K. F., MacLachlan, I., & Cullis, P. R. (2003). Transfection properties of stabilized plasmid-lipid particles containing cationic PEG lipids. Biochimica et biophysica acta, 1611(1-2), 204-216. doi:10.1016/s0005-2736(03)00058-0 |
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| 270 | Zhigaltsev, I. V., Maurer, N., Wong, K. F., & Cullis, P. R. (2002). Triggered release of doxorubicin following mixing of cationic and anionic liposomes. Biochimica et biophysica acta, 1565(1), 129-135. doi:10.1016/s0005-2736(02)00543-6 |
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| 269 | Gaucheron, J., Wong, T., Wong, K. F., Maurer, N., & Cullis, P. R. (2002). Synthesis and Properties of Novel Tetraalkyl Cationic Lipids. Bioconjugate Chemistry, 13(3), 671-675. doi:10.1021/bc0101259 |
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| 268 | Fenske, D. B., MacLachlan, I., & Cullis, P. R. (2002). Stabilized plasmid-lipid particles: a systemic gene therapy vector. Methods in Enzymology, 346, 36-71. doi:10.1016/s0076-6879(02)46048-x |
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| 267 | Cullis, P. R. (2002). Stabilized plasmid-lipid particles for systemic gene therapy. Cellular & Molecular Biology Letters, 7(2), 226. |
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| 266 | Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., & Scherrer, P. (2001). Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochimica et biophysica acta, 1510(1-2), 152-166. doi:10.1016/s0005-2736(00)00343-6 |
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| 265 | Maurer, N., Wong, K. F., Stark, H., Louie, L., McIntosh, D., Wong, T., Scherrer, P., Semple, S. C., & Cullis, P. R. (2001). Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes. Biophysical journal, 80(5), 2310-2326. doi:10.1016/s0006-3495(01)76202-9 |
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| 264 | Maurer, N., Fenske, D. B., & Cullis, P. R. (2001). Developments in liposomal drug delivery systems. Expert Opinion on Biological Therapy, 1(6), 923-947. doi:10.1517/14712598.1.6.923 |
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| 263 | Hafez, I. M., Maurer, N., & Cullis, P. R. (2001). On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Therapy, 8(15), 1188-1196. doi:10.1038/sj.gt.3301506 |
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| 262 | Hafez, I. M., & Cullis, P. R. (2001). Roles of lipid polymorphism in intracellular delivery. Advanced Drug Delivery Reviews, 47(2-3), 139-148. doi:10.1016/s0169-409x(01)00103-x |
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| 261 | Fenske, D. B., Palmer, L. R., Chen, T., Wong, K. F., & Cullis, P. R. (2001). Cationic poly(ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells. Biochimica et biophysica acta, 1512(2), 259-272. doi:10.1016/s0005-2736(01)00327-3 |
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| 260 | Fenske, D. B., MacLachlan, I., & Cullis, P. R. (2001). Long-circulating vectors for the systemic delivery of genes. Current Opinion in Molecular Therapeutics, 3(2), 153-158. Retrieved from http://europepmc.org/abstract/MED/11338928 |
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| 259 | Webb, M. S., Sarris, A. H., Cabanillas, F., Mayer, L. D., Bally, M. B., Burge, C., & Cullis, P. R. (2000). Clinical and Preclinical Pharmacology of Liposomal Vincristine. Journal of Liposome Research, 10(4), 501-512. doi:10.3109/08982100009031114 |
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| 258 | Tam, P., Monck, M., Lee, D., Ludkovski, O., Leng, E. C., Clow, K., Stark, H., Scherrer, P., Graham, R. W., & Cullis, P. R. (2000). Stabilized plasmid-lipid particles for systemic gene therapy. Gene Therapy, 7(21), 1867-1874. doi:10.1038/sj.gt.3301308 |
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| 257 | Scherrer, P., Maurer, N., Monck, M., Saravolac, E., Zhang, Y. P., Wheeler, J., Tam, P., Lam, A., & Cullis, P. R. (2000). Design and Properties of a Lipid-Based Carrier System for Systemic Gene Therapy. In G. Gregoriadis & B. McCormack (Eds.), Targeting of Drugs: Strategies for Gene Constructs and Delivery (Vol. 323, pp. 165-185). Amsterdam, Washington, D. C.: IOS Press. |
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| 256 | Saravolac, E. G., Ludkovski, O., Skirrow, R., Ossanlou, M., Zhang, Y. P., Giesbrecht, C., Thompson, J., Thomas, S., Stark, H., Cullis, P. R., & Scherrer, P. (2000). Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optimal transfection activity. Journal of Drug Targeting, 7(6), 423-437. doi:10.3109/10611860009102217 |
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| 255 | Oja, C., Tardi, P., Schutze-Redelmeier, M., & Cullis, P. R. (2000). Doxorubicin entrapped within liposome-associated antigens results in a selective inhibition of the antibody response to the linked antigen. Biochimica et biophysica acta, 1468(1-2), 31-40. doi:10.1016/s0005-2736(00)00178-4 |
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| 254 | Monck, M. A., Mori, A., Lee, D., Tam, P., Wheeler, J. J., Cullis, P. R., & Scherrer, P. (2000). Stabilized Plasmid–Lipid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumors following Intravenous Injection. Journal of Drug Targeting, 7(6), 439-452. doi:10.3109/10611860009102218 |
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| 253 | MacLachlan, I., Cullis, P. R., & Graham, R. W. (2000). Synthetic Virus Systems for Systemic Gene Therapy. In N. S. Templeton & D. D. Lasic (Eds.), Gene Therapy: Therapeutic Mechanisms and Strategies (pp. 267-290). New York: Marcel Dekker Inc. |
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| 252 | Lam, A. M., & Cullis, P. R. (2000). Calcium enhances the transfection potency of plasmid DNA-cationic liposome complexes. Biochimica et biophysica acta, 1463(2), 279-290. doi:10.1016/s0005-2736(99)00219-9 |
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| 251 | Huang, Y. Y., Maurer, N., & Cullis, P. R. (2000). Developing serum-stabilized cationic liposome-dna particles for gene therapy by preformed vesicles and ethanol method. Biomedical Engineering: Applications, Basis and Communications, 12, 217-222. | |
| 250 | Hafez, I. M., & Cullis, P. R. (2000). Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. Biochimica et biophysica acta, 1463(1), 107-114. doi:10.1016/s0005-2736(99)00186-8 |
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| 249 | Hafez, I. M., Ansell, S., & Cullis, P. R. (2000). Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids. Biophysical journal, 79(3), 1438-1446. doi:10.1016/S0006-3495(00)76395-8 |
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| 248 | Cullis, P. R., & Huang, Y. Y. (2000). Transfection of BHK cell by serum-stabilized cationic liposome-DNA particles. Biomedical Engineering: Applications, Basis and Communications, 12(6), 281-287. | |
| 247 | Cullis, P. R. (2000). Commentary: Liposomes by Accident. Journal of Liposome Research, 10(2-3), ix-xxiv. doi:10.3109/08982100009029380 |
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| 246 | Chen, T., Wong, K. F., Fenske, D. B., Palmer, L. R., & Cullis, P. R. (2000). Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups. Bioconjugate Chemistry, 11(3), 433-437. doi:10.1021/bc990171x |
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| 245 | Ansell, S. M., Harasym, T. O., Tardi, P. G., Buchkowsky, S. S., Bally, M. B., & Cullis, P. R. (2000). Antibody conjugation methods for active targeting of liposomes. Methods In Molecular Medicine, 25, 51-68. doi:10.1385/1-59259-075-6:51 |
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| 244 | Zhang, Y. P., Sekirov, L., Saravolac, E. G., Wheeler, J. J., Tardi, P., Clow, K., Leng, E., Sun, R., Cullis, P. R., & Scherrer, P. (1999). Stabilized plasmid-lipid particles for regional gene therapy: formulation and transfection properties. Gene Therapy, 6(8), 1438-1447. doi:10.1038/sj.gt.3300965 |
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| 243 | Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999). Stabilized plasmid-lipid particles: construction and characterization. Gene Therapy, 6(2), 271-281. doi:10.1038/sj.gt.3300821 |
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| 242 | Schoen, P., Chonn, A., Cullis, P. R., Wilschut, J., & Scherrer, P. (1999). Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles. Gene Therapy, 6(5), 823-832. doi:10.1038/sj.gt.3300919 |
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| 241 | Mok, K. W., Lam, A. M., & Cullis, P. R. (1999). Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochimica et biophysica acta, 1419(2), 137-150. doi:10.1016/s0005-2736(99)00059-0 |
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| 240 | Maurer-Spurej, E., Wong, K. F., Maurer, N., Fenske, D. B., & Cullis, P. R. (1999). Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients. Biochimica et biophysica acta, 1416(1-2), 1-10. doi:10.1016/s0005-2736(98)00204-1 |
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| 239 | Maurer, N., Mori, A., Palmer, L., Monck, M. A., Mok, K. W., Mui, B., Akhong, Q. F., & Cullis, P. R. (1999). Lipid-based systems for the intracellular delivery of genetic drugs. Molecular Membrane Biology, 16(1), 129-140. doi:10.1080/096876899294869 |
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| 238 | MacLachlan, I., Cullis, P., & Graham, R. W. (1999). Progress towards a synthetic virus for systemic gene therapy. Current Opinion in Molecular Therapeutics, 1(2), 252-259 |
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| 237 | Chen, T., Choi, L. S., Einstein, S., Klippenstein, M. A., Scherrer, P., & Cullis, P. R. (1999). Proton-Induced Permeability and Fusion of Large Unilamellar Vesicles by Covalently Conjugated Poly(2-Ethylacrylic Acid). Journal of Liposome Research, 9(3), 387-405. doi:10.3109/08982109909018658 |
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| 236 | Webb, M. S., Saxon, D., Wong, F. M., Lim, H. J., Wang, Z., Bally, M. B., Choi, L. S., Cullis, P. R., & Mayer, L. D. (1998). Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine. Biochimica et biophysica acta, 1372(2), 272-282. doi:10.1016/s0005-2736(98)00077-7 |
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| 235 | Semple, S. C., Chonn, A., & Cullis, P. R. (1998). Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo. Advanced Drug Delivery Reviews, 32(1-2), 3-17. doi:10.1016/s0169-409x(97)00128-2 |
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| 234 | Schmid, S. L., & Cullis, P. R. (1998). Membrane sorting. Endosome marker is fat not fiction. Nature, 392(6672), 135-136. doi:10.1038/32309 |
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| 233 | Mori, A., Chonn, A., Choi, L. S., Israels, A., Monck, M. A., & Cullis, P. R. (1998). Stabilization and Regulated Fusion of Liposomes Containing a Cationic Lipid Using Amphipathic Polyethyleneglycol Derivatives. Journal of Liposome Research, 8(2), 195-211. doi:10.3109/08982109809035526 |
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| 232 | Mayer, L. D., Cullis, P. R., & Bally, M. B. (1998). Chapter 4.2 - Designing therapeutically optimized liposomal anticancer delivery systems: Lessons from conventional liposomes. In D. D. Lasic & D. Papahadjopoulos (Eds.), Medical Applications of Liposomes (pp. 231-257). Amsterdam: Elsevier Science B.V. |
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| 231 | Maurer, N., Wong, K. F., Hope, M. J., & Cullis, P. R. (1998). Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study. Biochimica et biophysica acta, 1374(1-2), 9-20. doi:10.1016/s0005-2736(98)00125-4 |
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| 230 | Fenske, D. B., Wong, K. F., Maurer, E., Maurer, N., Leenhouts, J. M., Boman, N., Amankwa, L., & Cullis, P. R. (1998). Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients. Biochimica et biophysica acta, 1414(1-2), 188-204. doi:10.1016/s0005-2736(98)00166-7 |
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| 229 | Chonn, A., & Cullis, P. R. (1998). Recent advances in liposome technologies and their applications for systemic gene delivery. Advanced Drug Delivery Reviews, 30(1-3), 73-83. doi:10.1016/s0169-409x(97)00108-7 |
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| 228 | Cheung, B. C., Sun, T. H., Leenhouts, J. M., & Cullis, P. R. (1998). Loading of doxorubicin into liposomes by forming Mn2+-drug complexes. Biochimica et biophysica acta, 1414(1-2), 205-216. doi:10.1016/s0005-2736(98)00168-0 |
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| 227 | Boman, N. L., Cullis, P. R., Mayer, L. D., Bally, M. B., & Webb, M. S. (1998). Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations. In M. C. Woodle & G. Storm (Eds.), Long Circulating Liposomes: Old Drugs, New Therapeutics (pp. 29-49). Berlin, Heidelberg: Springer Berlin Heidelberg |
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| 226 | Bally, M. B., Lim, H., Cullis, P. R., & Mayer, L. D. (1998). Controlling the Drug Delivery Attributes of Lipid-Based Drug Formulations. Journal of Liposome Research, 8(3), 299-335. doi:10.3109/08982109809035537 |
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| 225 | Tardi, P. G., Swartz, E. N., Harasym, T. O., Cullis, P. R., & Bally, M. B. (1997). An immune response to ovalbumin covalently coupled to liposomes is prevented when the liposomes used contain doxorubicin. Journal of Immunological Methods, 210(2), 137-148. doi:10.1016/s0022-1759(97)00178-6 |
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| 224 | Parr, M. J., Masin, D., Cullis, P. R., & Bally, M. B. (1997). Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). Journal of Pharmacology and Experimental Therapeutics, 280(3), 1319-1327 |
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| 223 | Mok, K. W., & Cullis, P. R. (1997). Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA. Biophysical journal, 73(5), 2534-2545. doi:10.1016/S0006-3495(97)78282-1 |
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| 222 | Harasym, T. O., Cullis, P. R., & Bally, M. B. (1997). Intratumor distribution of doxorubicin following i.v. administration of drug encapsulated in egg phosphatidylcholine/cholesterol liposomes. Cancer Chemotherapy and Pharmacology, 40(4), 309-317. doi:10.1007/s002800050662 |
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| 221 | Felgner, P. L., Barenholz, Y., Behr, J. P., Cheng, S. H., Cullis, P. R., Huang, L., Jessee, J. A., Seymour, L., Szoka, F., Thierry, A. R., Wagner, E., & Wu, G. (1997). Nomenclature for Synthetic Gene Delivery Systems. Human Gene Therapy, 8(5), 511-512. doi:10.1089/hum.1997.8.5-511 |
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| 220 | Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., & Fenske, D. B. (1997). Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochimica et biophysica acta, 1331(2), 187-211. doi:10.1016/s0304-4157(97)00006-3 |
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| 219 | Bailey, A. L., Monck, M. A., & Cullis, P. R. (1997). pH-induced destabilization of lipid bilayers by a lipopeptide derived from influenza hemagglutinin. Biochimica et biophysica acta, 1324(2), 232-244. doi:10.1016/s0005-2736(96)00228-3 |
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| 218 | Bailey, A. L., & Cullis, P. R. (1997). Membrane fusion with cationic liposomes: effects of target membrane lipid composition. Biochemistry, 36(7), 1628-1634. doi:10.1021/bi961173x |
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| 217 | Bailey, A. L., & Cullis, P. R. (1997). Chapter 9 - Liposome Fusion. In R. M. Epand (Ed.), Current Topics in Membranes (Vol. 44, pp. 359-373): Academic Press |
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| 216 | Tardi, P. G., Boman, N. L., & Cullis, P. R. (1996). Liposomal doxorubicin. Journal of Drug Targeting, 4(3), 129-140. doi:10.3109/10611869609015970 |
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| 215 | Semple, S. C., Chonn, A., & Cullis, P. R. (1996). Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry, 35(8), 2521-2525. doi:10.1021/bi950414i |
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| 214 | Oja, C. D., Semple, S. C., Chonn, A., & Cullis, P. R. (1996). Influence of dose on liposome clearance: critical role of blood proteins. Biochimica et biophysica acta, 1281(1), 31-37. doi:10.1016/0005-2736(96)00003-x |
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| 213 | Lafleur, M., Bloom, M., Eikenberry, E. F., Gruner, S. M., Han, Y., & Cullis, P. R. (1996). Correlation between lipid plane curvature and lipid chain order. Biophysical journal, 70(6), 2747-2757. doi:10.1016/S0006-3495(96)79844-2 |
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| 212 | Holland, J. W., Hui, C., Cullis, P. R., & Madden, T. D. (1996). Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine. Biochemistry, 35(8), 2618-2624. doi:10.1021/bi952000v |
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| 211 | Holland, J. W., Cullis, P. R., & Madden, T. D. (1996). Poly(ethylene glycol)-lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids. Biochemistry, 35(8), 2610-2617. doi:10.1021/bi951999j |
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| 210 | Fenske, D. B., & Cullis, P. R. (1996). Lipid Polymorphism. In The Encyclopedia of Nuclear Magnetic Resonance (pp. 2730-2735). New York: John Wiley & Sons |
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| 209 | Cullis, P. R., Fenske, D. B., & Hope, M. J. (1996). Chapter 1 - Physical properties and functional roles of lipids in membranes. In D. E. Vance & J. E. Vance (Eds.), New Comprehensive Biochemistry (Vol. 31, pp. 1-33): Elsevier |
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| 208 | Boman, N. L., Tron, V. A., Bally, M. B., & Cullis, P. R. (1996). Vincristine-induced dermal toxicity is significantly reduced when the drug is given in liposomes. Cancer Chemotherapy and Pharmacology, 37(4), 351-355. doi:10.1007/s002800050396 |
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| 207 | Mui, B. L., Döbereiner, H. G., Madden, T. D., & Cullis, P. R. (1995). Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles. Biophysical journal, 69(3), 930-941. doi:10.1016/S0006-3495(95)79967-2 |
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| 206 | Longman, S. A., Tardi, P. G., Parr, M. J., Choi, L., Cullis, P. R., & Bally, M. B. (1995). Accumulation of protein-coated liposomes in an extravascular site: influence of increasing carrier circulation lifetimes. Journal of Pharmacology and Experimental Therapeutics, 275(3), 1177-1184 |
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| 205 | Longman, S. A., Cullis, P. R., Choi, L., de Jong, G., & Bally, M. B. (1995). A two-step targeting approach for delivery of doxorubicin-loaded liposomes to tumour cells in vivo. Cancer Chemotherapy and Pharmacology, 36(2), 91-101. doi:10.1007/bf00689191 |
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| 204 | Longman, S. A., Cullis, P. R., & Bally, M. B. (1995). A model approach for assessing liposome targeting in vivo. Drug Delivery, 2(3-4), 156-165. doi:10.3109/10717549509031365 |
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| 203 | Harasym, T. O., Tardi, P., Longman, S. A., Ansell, S. M., Bally, M. B., Cullis, P. R., & Choi, L. S. (1995). Poly(ethylene glycol)-modified phospholipids prevent aggregation during covalent conjugation of proteins to liposomes. Bioconjugate Chemistry, 6(2), 187-194. doi:10.1021/bc00032a006 |
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| 202 | Fenske, D. B., Monck, M. A., Cullis, P. R., & Hope, M. J. (1995). The functional roles of lipids in biological membranes. In A. G. lee (Ed.), Biomembranes: A Multi-Volume Treatise (Vol. 1, pp. 1-28): JAI |
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| 201 | Cullis, P. R., & Hope, M. J. (1995). Liposomes, dimitri papahadjopoulos, and us. Journal of Liposome Research, 5(4), 829-836. doi:10.3109/08982109509012684 |
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| 200 | Chonn, A., Semple, S. C., & Cullis, P. R. (1995). β2-Glycoprotein I Is a Major Protein Associated with Very Rapidly Cleared Liposomes in Vivo, Suggesting a Significant Role in the Immune Clearance of "Non-self" Particles. Journal of Biological Chemistry, 270(43), 25845-25849. doi:10.1074/jbc.270.43.25845 |
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| 199 | Chonn, A., & Cullis, P. R. (1995). Recent advances in liposomal drug-delivery systems. Current Opinion in Biotechnology, 6(6), 698-708. doi:10.1016/0958-1669(95)80115-4 |
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| 198 | Boman, N. L., Cullis, P. R., Bally, M. B., & Mayer, L. D. (1995). Preclinical and Clinical Activity of Liposomal Doxorubicin. In Liposomes in Biomedical Applications (pp. 85-103): Harwood Academic Publishers |
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| 197 | Boman, N. L., Bally, M. B., Cullis, P. R., Mayer, L. D., & Webb, M. S. (1995). Encapsulation of Vincristine in Liposomes Reduces its Toxicity and Improves its Anti-Tumor Efficacy. Journal of Liposome Research, 5(3), 523-541. doi:10.3109/08982109509010240 |
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| 196 | Wheeler, J. J., Veiro, J. A., & Cullis, P. R. (1994). Ionophore-mediated loading of Ca 2+ into large unilamellar vesicles in response to transmembrane pH gradients. Molecular Membrane Biology, 11(3), 151-157. doi:10.3109/09687689409162233 |
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| 195 | Parr, M. J., Ansell, S. M., Choi, L. S., & Cullis, P. R. (1994). Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles. Biochimica et biophysica acta, 1195(1), 21-30. doi:10.1016/0005-2736(94)90004-3 |
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| 194 | Mui, B. L., Cullis, P. R., Pritchard, P. H., & Madden, T. D. (1994). Influence of plasma on the osmotic sensitivity of large unilamellar vesicles prepared by extrusion. Journal of Biological Chemistry, 269(10), 7364-7370 |
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| 193 | Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994). The Use of Transmembrane pH Gradient-Driven Drug Encapsulation in the Pharmacodynamic Evaluation of Liposomal Doxorubicin. Journal of Liposome Research, 4(1), 529-553. doi:10.3109/08982109409037060 |
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| 192 | Lewis, R. N., McElhaney, R. N., Monck, M. A., & Cullis, P. R. (1994). Studies of highly asymmetric mixed-chain diacyl phosphatidylcholines that form mixed-interdigitated gel phases: Fourier transform infrared and 2H NMR spectroscopic studies of hydrocarbon chain conformation and orientational order in the liquid-crystalline state. Biophysical journal, 67(1), 197-207. doi:10.1016/s0006-3495(94)80470-9 |
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| 191 | Devine, D. V., Wong, K., Serrano, K., Chonn, A., & Cullis, P. R. (1994). Liposome-complement interactions in rat serum: implications for liposome survival studies. Biochimica et biophysica acta, 1191(1), 43-51. doi:10.1016/0005-2736(94)90231-3 |
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| 190 | Chonn, A., Semple, S. C., & Cullis, P. R. (1994). Protein-Membrane Interactions in the Complex Biological Milieu. In Biological Membranes: Structure, Biogenesis and Dynamics (pp. 101-106). Berlin, Heidelberg: Springer |
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| 189 | Chakrabarti, A. C., Clark-Lewis, I., & Cullis, P. R. (1994). Influence of Charge, Charge Distribution, and Hydrophobicity on the Transport of Short Model Peptides into Liposomes in Response to Transmembrane pH Gradients. Biochemistry, 33(28), 8479-8485. doi:10.1021/bi00194a012 |
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| 188 | Boman, N. L., Masin, D., Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994). Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors. Cancer Research, 54(11), 2830-2833 |
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| 187 | Bally, M. B., Masin, D., Nayar, R., Cullis, P. R., & Mayer, L. D. (1994). Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice. Cancer Chemotherapy and Pharmacology, 34(2), 137-146. doi:10.1007/BF00685931 |
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| 186 | Bailey, A. L., & Cullis, P. R. (1994). Modulation of Membrane Fusion by Asymmetric Transbilayer Distributions of Amino Lipids. Biochemistry, 33(42), 12573-12580. doi:10.1021/bi00208a007 |
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| 185 | Parr, M. J., Bally, M. B., & Cullis, P. R. (1993). The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade. Biochimica et biophysica acta, 1168(2), 249-252. doi:10.1016/0005-2760(93)90132-s |
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| 184 | Mui, B. L., Cullis, P. R., Evans, E. A., & Madden, T. D. (1993). Osmotic properties of large unilamellar vesicles prepared by extrusion. Biophysical journal, 64(2), 443-453. doi:10.1016/S0006-3495(93)81385-7 |
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| 183 | Monck, M. A., Bloom, M., Lafleur, M., Lewis, R. N. A. H., McElhaney, R. N., & Cullis, P. R. (1993). Evidence for two pools of cholesterol in the Acholeplasma laidlawii strain B membrane: A deuterium NMR and DSC study. Biochemistry, 32(12), 3081-3088. doi:10.1021/bi00063a020 |
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| 182 | Mayer, L. D., Nayar, R., Thies, R. L., Boman, N. L., Cullis, P. R., & Bally, M. B. (1993). Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia. Cancer Chemotherapy and Pharmacology, 33(1), 17-24. doi:10.1007/bf00686017 |
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| 181 | Mayer, L. D., Madden, T. D., Bally, M. B., & Cullis, P. R. (1993). pH Gradient-Mediated Drug Entrapment in Liposomes. In Liposome Technology: Entrapment of Drugs and Other Materials (2 ed., Vol. 2, pp. 27-44) | |
| 180 | Loughrey, H. C., Choi, L. S., Wong, K. F., Cullis, P. R., & Bally, M. B. (1993). Preparation of Streptavidin-Liposomes for Use in Ligand-Specific Targeting Applications. In Liposome Technology: Interactions of Liposomes with the Biological Milieu (2 ed., Vol. 3, pp. 163-178) |
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| 179 | Kanter, P. M., Bullard, G. A., Pilkiewicz, F. G., Mayer, L. D., Cullis, P. R., & Pavelic, Z. P. (1993). Preclinical toxicology study of liposome encapsulated doxorubicin (TLC D-99): comparison with doxorubicin and empty liposomes in mice and dogs. In Vivo, 7(1), 85-95 | |
| 178 | Hope, M. J., Nayar, R., Mayer, L. D., & Cullis, P. R. (1993). Reduction of Liposome Size and Preparation of Unilamellar Vesicles by Extrusion Techniques. In Liposome Technology: Liposome Preparation and Related Techniques (2 ed., Vol. 1, pp. 123). Boca Raton, FL: CRC Press, Inc. |
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| 177 | Harrigan, P. R., Wong, K. F., Redelmeier, T. E., Wheeler, J. J., & Cullis, P. R. (1993). Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients. Biochimica et biophysica acta, 1149(2), 329-338. doi:10.1016/0005-2736(93)90218-o |
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| 176 | Fenske, D. B., & Cullis, P. R. (1993). Acyl chain orientational order in large unilamellar vesicles: comparison with multilamellar liposomes: a 2H and 31P nuclear magnetic resonance study. Biophysical journal, 64(5), 1482-1491. doi:10.1016/S0006-3495(93)81515-7 |
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| 175 | Embree, L., Gelmon, K. A., Lohr, A., Mayer, L. D., Coldman, A. J., Cullis, P. R., Palaitis, W., Pilkiewicz, F. G., Hudon, N. J., Heggie, J. R., & Goldie, J. H. (1993). Chromatographic Analysis and Pharmacokinetics of Liposome-Encapsulated Doxorubicin in Non-Small-Cell Lung Cancer Patients. Journal of Pharmaceutical Sciences, 82(6), 627-634. doi:10.1002/jps.2600820617 | |
| 174 | Boman, N. L., Mayer, L. D., & Cullis, P. R. (1993). Optimization of the retention properties of vincristine in liposomal systems. Biochimica et biophysica acta, 1152(2), 253-258. doi:10.1016/0005-2736(93)90256-Y |
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| 173 | Wilschut, J., Scholma, J., Eastman, S. J., Hope, M. J., & Cullis, P. R. (1992). Ca(2+)-induced fusion of phospholipid vesicles containing free fatty acids: modulation by transmembrane pH gradients. Biochemistry, 31(10), 2629-2636. doi:10.1021/bi00125a001 |
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| 172 | Monck, M. A., Bloom, M., Lafleur, M., Lewis, R. N. A. H., McElhaney, R. N., & Cullis, P. R. (1992). Influence of lipid composition on the orientational order in Acholeplasma laidlawii strain B membranes: A deuterium NMR study. Biochemistry, 31(41), 10037-10043. doi:10.1021/bi00156a025 |
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| 171 | Kitson, N., Monck, M. A., Wong, K., Thewalt, J., & Cullis, P. R. (1992). The influence of cholesterol 3-sulphate on phase behaviour and hydrocarbon order in model membrane systems. Biochimica et biophysica acta, 1111(1), 127-133. doi:10.1016/0005-2736(92)90282-Q |
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| 170 | Harrigan, P. R., Hope, M. J., Redelmeier, T. E., & Cullis, P. R. (1992). Determination of transmembrane pH gradients and membrane potentials in liposomes. Biophysical journal, 63(5), 1336-1345. doi:10.1016/S0006-3495(92)81711-3 |
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| 169 | Fenske, D. B., & Cullis, P. R. (1992). Chemical exchange between lamellar and non-lamellar lipid phases. A one- and two-dimensional 31P-NMR study. Biochimica et biophysica acta, 1108(2), 201-209. doi:10.1016/0005-2736(92)90026-I |
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| 168 | Eastman, S. J., Hope, M. J., Wong, K. F., & Cullis, P. R. (1992). Influence of phospholipid asymmetry on fusion between large unilamellar vesicles. Biochemistry, 31(17), 4262-4268. doi:10.1021/bi00132a016 |
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| 167 | Chonn, A., Semple, S. C., & Cullis, P. R. (1992). Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. Journal of Biological Chemistry, 267(26), 18759-18765. |
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| 166 | Chonn, A., & Cullis, P. R. (1992). Ganglioside GM1 and Hydrophilic Polymers Increase Liposome Circulation Times by Inhibiting the Association of Blood Proteins. Journal of Liposome Research, 2(3), 397-410. doi:10.3109/08982109209010217 |
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| 165 | Chakrabarti, A. C., Veiro, J. A., Wong, N. S., Wheeler, J. J., & Cullis, P. R. (1992). Generation and characterization of iron- and barium-loaded liposomes. Biochimica et biophysica acta, 1108(2), 233-239. doi:10.1016/0005-2736(92)90030-P |
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| 164 | Chakrabarti, A. C., Clark-Lewis, I., Harrigan, P. R., & Cullis, P. R. (1992). Uptake of basic amino acids and peptides into liposomes in response to transmembrane pH gradients. Biophysical journal, 61(1), 228-234. doi:10.1016/S0006-3495(92)81829-5 |
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| 163 | Eastman, S. J., Hope, M. J., & Cullis, P. R. (1991). Transbilayer transport of phosphatidic acid in response to transmembrane pH gradients. Biochemistry, 30(7), 1740-1745. doi:10.1021/bi00221a002 |
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| 162 | Cullis, P. R., Bally, M. B., Madden, T. D., Mayer, L. D., & Hope, M. J. (1991). pH gradients and membrane transport in liposomal systems. Trends in Biotechnology, 9(1), 268-272. doi:10.1016/0167-7799(91)90088-Y |
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| 161 | Chonn, A., Semple, S. C., & Cullis, P. R. (1991). Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo. Biochimica et biophysica acta, 1070(1), 215-222. doi:10.1016/0005-2736(91)90167-7 |
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| 160 | Chonn, A., Cullis, P. R., & Devine, D. V. (1991). The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. The Journal of Immunology, 146(12), 4234-4241 |
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| 159 | Veiro, J. A., & Cullis, P. R. (1990). A novel method for the efficient entrapment of calcium in large unilamellar phospholipid vesicles. Biochimica et biophysica acta, 1025(1), 109-115. doi:10.1016/0005-2736(90)90197-V |
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| 158 | Thies, R. L., Cowens, D. W., Cullis, P. R., Bally, M. B., & Mayer, L. D. (1990). Method for rapid separation of liposome-associated doxorubicin from free doxorubicin in plasma. Analytical Biochemistry, 188(1), 65-71. doi:10.1016/0003-2697(90)90528-h |
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| 157 | Redelmeier, T. E., Hope, M. J., & Cullis, P. R. (1990). On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients. Biochemistry, 29(12), 3046-3053. doi:10.1021/bi00464a022 |
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| 156 | Mayer, L. D., Tai, L. C., Bally, M. B., Mitilenes, G. N., Ginsberg, R. S., & Cullis, P. R. (1990). Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients. Biochimica et biophysica acta, 1025(2), 143-151. doi:10.1016/0005-2736(90)90091-2 |
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| 155 | Mayer, L. D., Bally, M. B., Loughrey, H., Masin, D., & Cullis, P. R. (1990). Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors. Cancer Research, 50(3), 575-579 |
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| 154 | Mayer, L. D., Bally, M. B., Cullis, P. R., Wilson, S. L., & Emerman, J. T. (1990). Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor. Cancer Letters, 53(2-3), 183-190. doi:10.1016/0304-3835(90)90212-g |
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| 153 | Mayer, L. D., Bally, M. B., & Cullis, P. R. (1990). Strategies for Optimizing Liposomal Doxorubicin. Journal of Liposome Research, 1(4), 463-480. doi:10.3109/08982109009036008 |
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| 152 | Madden, T. D., Janoff, A. S., & Cullis, P. R. (1990). Incorporation of amphotericin B into large unilamellar vesicles composed of phosphatidylcholine and phosphatidylglycerol. Chemistry and Physics of Lipids, 52(3-4), 189-198. doi:10.1016/0009-3084(90)90114-7 |
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| 151 | Madden, T. D., Harrigan, P. R., Tai, L. C., Bally, M. B., Mayer, L. D., Redelmeier, T. E., Loughrey, H. C., Tilcock, C. P., Reinish, L. W., & Cullis, P. R. (1990). The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey. Chemistry and Physics of Lipids, 53(1), 37-46. doi:10.1016/0009-3084(90)90131-a |
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| 150 | Loughrey, H. C., Wong, K. F., Choi, L. S., Cullis, P. R., & Bally, M. B. (1990). Protein-liposome conjugates with defined size distributions. Biochimica et biophysica acta, 1028(1), 73-81. doi:10.1016/0005-2736(90)90267-r |
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| 149 | Loughrey, H. C., Choi, L. S., Cullis, P. R., & Bally, M. B. (1990). Optimized procedures for the coupling of proteins to liposomes. Journal of Immunological Methods, 132(1), 25-35. doi:10.1016/0022-1759(90)90394-B |
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| 148 | Loughrey, H. C., Bally, M. B., Reinish, L. W., & Cullis, P. R. (1990). The binding of phosphatidylglycerol liposomes to rat platelets is mediated by complement. Journal of Thrombosis and Haemostasis, 64(1), 172-176 |
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| 147 | Lafleur, M., Cullis, P. R., Fine, B., & Bloom, M. (1990). Comparison of the orientational order of lipid chains in the L.alpha. and HII phases. Biochemistry, 29(36), 8325-8333. doi:10.1021/bi00488a018 |
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| 146 | Lafleur, M., Cullis, P. R., & Bloom, M. (1990). Modulation of the orientational order profile of the lipid acyl chain in the Lα phase. European Biophysics Journal, 19(2), 55-62. doi:10.1007/BF00185086 |
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| 145 | Lafleur, M., Bloom, M., & Cullis, P. R. (1990). Lipid polymorphism and hydrocarbon order. Biochemistry and Cell Biology, 68(1), 1-8. doi:10.1139/o90-001 |
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| 144 | Harrigan, P. R., Madden, T. D., & Cullis, P. R. (1990). Protection of liposomes during dehydration or freezing. Chemistry and Physics of Lipids, 52(2), 139-149. doi:10.1016/0009-3084(90)90157-M |
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| 143 | Cullis, P. R., Tilcock, C. P., & Hope, M. J. (1990). Lipid Polymorphism. In Membrane Fusion. New York: Marcel Dekker, Inc. |
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| 142 | Chakrabarti, A. C., Veiro, J. A., Wong, N., & Cullis, P. R. (1990). Use of transmembrane pH gradients and A23187 to produce dense iron liposomes. Biochemical Society Transactions, 18(5), 946-947. doi:10.1042/bst0180946 | |
| 141 | Boni, L. T., Perkins, W. R., Minchey, S. R., Bolcsak, L. E., Gruner, S. M., Cullis, P. R., Hope, M. J., & Janoff, A. S. (1990). Polymorphic phase behavior of alpha-tocopherol hemisuccinate. Chemistry and Physics of Lipids, 54(3), 193-203. doi:10.1016/0009-3084(90)90012-G |
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| 140 | Bally, M. B., Nayar, R., Masin, D., Hope, M. J., Cullis, P. R., & Mayer, L. D. (1990). Liposomes with entrapped doxorubicin exhibit extended blood residence times. Biochimica et biophysica acta, 1023(1), 133-139. doi:10.1016/0005-2736(90)90018-j |
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| 139 | Bally, M. B., Nayar, R., Masin, D., Cullis, P. R., & Mayer, L. D. (1990). Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes. Cancer Chemotherapy and Pharmacology, 27(1), 13-19. doi:10.1007/BF00689270 |
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| 138 | Unger, E. C., MacDougall, P., Cullis, P. R., & Tilcock, C. P. (1989). Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI. Magnetic Resonance Imaging, 7(4), 417-423. doi:10.1016/0730-725x(89)90491-8 |
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| 137 | Tilcock, C. P. S., Unger, E., Cullis, P. R., & MacDougall, P. (1989). Liposomal Gd-DTPA: preparation and characterization of relaxivity. Radiology, 171(1), 77-80. doi:10.1148/radiology.171.1.2928549 |
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| 136 | Tilcock, C. P. S., Dempsey, T., Cullis, P. R., & Fisher, D. (1989). The Partitioning of Liposomes of Defined Size and Composition. In D. Fisher & I. A. Sutherland (Eds.), Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology (pp. 179-180). Boston, MA: Springer US. |
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| 135 | Tilcock, C. P. S., Cullis, P. R., Dempsey, T., Youens, B. N., & Fisher, D. (1989). Aqueous two-phase polymer partitioning of lipid vesicles of defined size and composition. Biochimica et biophysica acta, 979(2), 208-214. doi:10.1016/0005-2736(89)90436-7 |
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| 134 | Tilcock, C. P. S., Chin, R., Veiro, J., Cullis, P. R., & Fisher, D. (1989). Detection of surface charge-related properties in model membrane systems by aqueous two-phase partition. Biochimica et biophysica acta, 986(1), 167-171. doi:10.1016/0005-2736(89)90287-3 |
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| 133 | Redelmeier, T. E., Mayer, L. D., Wong, K. F., Bally, M. B., & Cullis, P. R. (1989). Proton flux in large unilamellar vesicles in response to membrane potentials and pH gradients. Biophysical journal, 56(2), 385-393. doi:10.1016/S0006-3495(89)82684-0 |
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| 132 | Post, C. B., Ray, W. J., Jr., & Gorenstein, D. G. (1989). Time-dependent 31P saturation transfer in the phosphoglucomutase reaction. Characterization of the spin system for the Cd(II) enzyme and evaluation of rate constants for the transfer process. Biochemistry, 28(2), 548-558. doi:10.1021/bi00428a021 |
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| 131 | Parmar, Y. I., Sparks, D. L., Frohlich, J., Cullis, P. R., & Pritchard, P. H. (1989). Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy. Journal of Lipid Research, 30(5), 765-771. |
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| 130 | Ostro, M. J., & Cullis, P. R. (1989). Use of liposomes as injectable-drug delivery systems. American Journal of Hospital Pharmacy, 46(8), 1576-1587. | |
| 129 | Nayar, R., Hope, M. J., & Cullis, P. R. (1989). Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion technique. Biochimica et biophysica acta, 986(2), 200-206. doi:10.1016/0005-2736(89)90468-9 |
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| 128 | Mayer, L. D., Tai, L. C., Ko, D. S., Masin, D., Ginsberg, R. S., Cullis, P. R., & Bally, M. B. (1989). Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Research, 49(21), 5922-5930. |
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| 127 | Lafleur, M., Fine, B., Sternin, E., Cullis, P. R., & Bloom, M. (1989). Smoothed orientational order profile of lipid bilayers by 2H-nuclear magnetic resonance. Biophysical journal, 56(5), 1037-1041. doi:10.1016/S0006-3495(89)82749-3 |
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| 126 | Hope, M. J., Wong, K. F., & Cullis, P. R. (1989). Freeze-fracture of lipids and model membrane systems. Journal of Electron Microscopy Technique, 13(4), 277-287. doi:10.1002/jemt.1060130403 |
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| 125 | Hope, M. J., Redelmeier, T. E., Wong, K. F., Rodrigueza, W., & Cullis, P. R. (1989). Phospholipid asymmetry in large unilamellar vesicles induced by transmembrane pH gradients. Biochemistry, 28(10), 4181-4187. doi:10.1021/bi00436a009 |
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| 124 | Eastman, S. J., Wilschut, J., Cullis, P. R., & Hope, M. J. (1989). Intervesicular exchange of lipids with weak acid and weak base characteristics: influence of transmembrane pH gradients. Biochimica et biophysica acta, 981(2), 178-184. doi:10.1016/0005-2736(89)90026-6 |
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| 123 | Doerschuk, C. M., Gie, R. P., Bally, M. B., Cullis, P. R., & Reinish, L. W. (1989). Platelet distribution in rabbits following infusion of liposomes. Journal of Thrombosis and Haemostasis, 61(3), 392-396. |
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| 122 | Cullis, P. R., Mayer, L. D., Bally, M. B., Madden, T. D., & Hope, M. J. (1989). Generating and loading of liposomal systems for drug-delivery applications. Advanced Drug Delivery Reviews, 3(3), 267-282. doi:10.1016/0169-409X(89)90024-0 |
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| 121 | Balazsovits, J. A. E., Mayer, L. D., Bally, M. B., Cullis, P. R., McDonell, M., Ginsberg, R. S., & Falk, R. E. (1989). Analysis of the effect of liposome encapsulation on the vesicant properties, acute and cardiac toxicities, and antitumor efficacy of doxorubicin. Cancer Chemotherapy and Pharmacology, 23(2), 81-86. doi:10.1007/BF00273522 |
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| 120 | Unger, E., Needleman, P., Cullis, P., & Tilcock, C. (1988). Gadolinium-DTPA liposomes as a potential MRI contrast agent. Work in progress. Investigative radiology, 23(12), 928-932. doi:10.1097/00004424-198812000-00010 |
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| 119 | Tilcock, C. P. S., Sommerman, E. F., Molday, R. S., & Cullis, P. R. (1988). Magnetic Filtration of Vesicles Containing Iron-Dextran Particles. Journal of Liposome Research, 1, 137-150. doi:10.3109/08982108809035987 |
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| 118 | Tilcock, C. P. S., Cullis, P. R., & Gruner, S. M. (1988). Calcium-induced phase separation phenomena in multicomponent unsaturated lipid mixtures. Biochemistry, 27(5), 1415-1420. doi:10.1021/bi00405a004 |
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| 117 | Sternin, E., Fine, B., Bloom, M., Tilcock, C. P., Wong, K. F., & Cullis, P. R. (1988). Acyl chain orientational order in the hexagonal HII phase of phospholipid-water dispersions. Biophysical journal, 54(4), 689-694. doi:10.1016/S0006-3495(88)83004-2 |
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| 116 | Reinish, L. W., Bally, M. B., Loughrey, H. C., & Cullis, P. R. (1988). Interactions of liposomes and platelets. Thrombosis and haemostasis, 60(3), 518-523 |
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| 115 | Nayar, R., Tilcock, C. P. S., Hope, M. J., Cullis, P. R., & Schroit, A. J. (1988). N-Succinyldioleoylphosphatidylethanolamine: structural preferences in pure and mixed model membranes. Biochimica et biophysica acta, 937, 31-41. doi:10.1016/0005-2736(88)90224-6 |
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| 114 | Mayer, L. D., Wong, K. F., Menon, K., Chong, C., Harrigan, P. R., & Cullis, P. R. (1988). Influence of ion gradients on the transbilayer distribution of dibucaine in large unilamellar vesicles. Biochemistry, 27(6), 2053-2060. doi:10.1021/bi00406a036 |
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| 113 | Madden, T. D., Tilcock, C. P. S., Wong, K., & Cullis, P. R. (1988). Spontaneous vesiculation of large multilamellar vesicles composed of saturated phosphatidylcholine and phosphatidylglycerol mixtures. Biochemistry, 27(24), 8724-8730. doi:10.1021/bi00424a006 |
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| 112 | Janoff, A. S., Kurtz, C. L., Jablonski, R. L., Minchey, S. R., Boni, L. T., Gruner, S. M., Cullis, P. R., Mayer, L. D., & Hope, M. J. (1988). Characterization of cholesterol hemisuccinate and α-tocopherol hemisucccinate vesicles. Biochimica et biophysica acta, 941(2), 165-175. doi:10.1016/0005-2736(88)90177-0 |
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| 111 | Janoff, A. S., Boni, L. T., Popescu, M. C., Minchey, S. R., Cullis, P. R., Madden, T. D., Taraschi, T., Gruner, S. M., Shyamsunder, E., & Tate, M. W. (1988). Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proceedings of the National Academy of Sciences of the United States of America, 85(16), 6122-6126. doi:10.1073/pnas.85.16.6122 |
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| 110 | Gruner, S. M., Tate, M. W., Kirk, G. L., So, P. T. C., Turner, D. C., Keane, D. T., Tilcock, C. P. S., & Cullis, P. R. (1988). X-ray diffraction study of the polymorphic behavior of N-methylated dioleoylphosphatidylethanolamine. Biochemistry, 27(8), 2853-2866. doi:10.1021/bi00408a029 |
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| 109 | Cullis, P. R., & Hope, M. J. (1988). Lipid Polymorphism, Lipid Asymmetry and Membrane Fusion. In S. Ohki, D. Doyle, T. D. Flanagan, S. W. Hui, & E. Mayhew (Eds.), Molecular Mechanisms of Membrane Fusion (pp. 37-51). Boston, MA: Springer US |
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| 108 | Bally, M. B., Mayer, L. D., Loughrey, H., Redelmeier, T., Madden, T. D., Wong, K., Harrigan, P. R., Hope, M. J., & Cullis, P. R. (1988). Dopamine accumulation in large unilamellar vesicle systems induced by transmembrane ion gradients. Chemistry and Physics of Lipids, 47(2), 97-107. doi:10.1016/0009-3084(88)90078-3 |
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| 107 | Bally, M. B., Hope, M. J., Mayer, L. D., Madden, T. D., & Cullis, P. R. (1988). Novel Procedures for Generating and Loading Liposomal Systems (G. Gregoriadis Ed.): John Wiley & Sons Ltd |
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| 106 | Wong, K. F., Parmar, Y. I., Mayer, L. D., Pritchard, P. H., & Cullis, P. R. (1987). Detection of protein-free lipoprotein analogues with an apolar lipid core by freeze-etch electron microscopy. Biochimica et biophysica acta, 921(2), 411-414. doi:10.1016/0005-2760(87)90044-0 |
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| 105 | Tilcock, C. P. S., & Cullis, P. R. (1987). Lipid Polymorphism. Annals of the New York Academy of Sciences, 492(1), 88-102. doi:10.1111/j.1749-6632.1987.tb48657.x |
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| 104 | Sparks, D. L., Frohlich, J., Cullis, P. R., & Pritchard, P. H. (1987). Cholesteryl ester transfer activity in plasma measured by using solid-phase-bound high-density lipoprotein. Clinical Chemistry, 33(3), 390-393. doi:10.1093/clinchem/33.3.390 |
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| 103 | Rauch, J., Tannenbaum, H., Senécal, J. L., Janoff, A. S., Cullis, P. R., & Frojmovic, M. M. (1987). Polyfunctional properties of hybridoma lupus anticoagulant antibodies. The Journal of Rheumatology. Supplement, 14 Suppl 13, 132-137 | |
| 102 | Madden, T. D., Hope, M. J., & Cullis, P. R. (1987). Modelling the biological membrane. Biochemical Society Transactions, 15(1), 75 |
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| 101 | Loughrey, H., Bally, M. B., & Cullis, P. R. (1987). A non-covalent method of attaching antibodies to liposomes. Biochimica et biophysica acta, 901(1), 157-160. doi:10.1016/0005-2736(87)90267-7 |
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| 100 | Hope, M. J., & Cullis, P. R. (1987). Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. Journal of Biological Chemistry, 262(9), 4360-4366 |
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| 99 | Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., & Janoff, A. S. (1987). Liposomes as Pharmaceuticals. New York: Marcel Dekker | |
| 98 | Tilcock, C. P. S., Cullis, P. R., Hope, M. J., & Gruner, S. M. (1986). Polymorphic phase behavior of unsaturated lysophosphatidylethanolamines: A phosphorus-31 NMR and x-ray diffraction study. Biochemistry, 25(4), 816-822. doi:10.1021/bi00352a013 |
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| 97 | Tilcock, C. P. S., Cullis, P. R., & Gruner, S. M. (1986). On the validity of 31P-NMR determinations of phospholipid polymorphic phase behaviour. Chemistry and Physics of Lipids, 40(1), 47-56. doi:10.1016/0009-3084(86)90061-7 |
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| 96 | Richards, R. L., Habbersett, R. C., Scher, I., Janoff, A. S., Schieren, H. P., Mayer, L. D., Cullis, P. R., & Alving, C. R. (1986). Influence of vesicle size on complement-dependent immune damage to liposomes. Biochimica et biophysica acta, 855(2), 223-230. doi:10.1016/0005-2736(86)90168-9 |
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| 95 | Rauch, J., Tannenbaum, M., Tannenbaum, H., Ramelson, H., Cullis, P. R., Tilcock, C. P. S., Hope, M. J., & Janoff, A. S. (1986). Hybridoma Lupus Anticoagulants Distinguish between Bilayer and Nonbilayer Phase Lipid Systems. Annals of the New York Academy of Sciences, 475(1), 366-369. doi:10.1111/j.1749-6632.1986.tb20896.x |
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| 94 | Rauch, J., Tannenbaum, M., Tannenbaum, H., Ramelson, H., Cullis, P. R., Tilcock, C. P. S., Hope, M. J., & Janoff, A. S. (1986). Human hybridoma lupus anticoagulants distinguish between lamellar and hexagonal phase lipid systems. Journal of Biological Chemistry, 261(21), 9672-9677. Retrieved from http://www.jbc.org/content/261/21/9672.abstract |
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| 93 | Mayer, L. D., Hope, M. J., & Cullis, P. R. (1986). Vesicles of variable sizes produced by a rapid extrusion procedure. Biochimica et biophysica acta, 858(1), 161-168. doi:10.1016/0005-2736(86)90302-0 |
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| 92 | Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1986). Techniques for encapsulating bioactive agents into liposomes. Chemistry and Physics of Lipids, 40(2-4), 333-345. doi:10.1016/0009-3084(86)90077-0 |
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| 91 | Mayer, L. D., Bally, M. B., & Cullis, P. R. (1986). Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochimica et biophysica acta, 857(1), 123-126. doi:10.1016/0005-2736(86)90105-7 |
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| 90 | Hope, M. J., Bally, M. B., Mayer, L. D., Janoff, A. S., & Cullis, P. R. (1986). Generation of multilamellar and unilamellar phospholipid vesicles. Chemistry and Physics of Lipids, 40(2), 89-107. doi:10.1016/0009-3084(86)90065-4 |
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| 89 | Cullis, P. R., Hope, M. J., & Tilcock, C. P. S. (1986). Lipid polymorphism and the roles of lipids in membranes. Chemistry and Physics of Lipids, 40(2), 127-144. doi:10.1016/0009-3084(86)90067-8 |
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| 88 | Cullis, P. R., De Kruijff, B., Verkleij, A. J., & Hope, M. J. (1986). Lipid polymorphism and membrane fusion. Biochemical Society Transactions, 14(2), 242-245. doi:10.1042/bst0140242 | |
| 87 | Zhang, Y. Z., Capaldi, R. A., Cullis, P. R., & Madden, T. D. (1985). Orientation of cytochrome c oxidase molecules in the two populations of reconstituted vesicles resolved by column chromatography on DEAE-Sephacryl. Biochimica et biophysica acta, 808(1), 209-211. doi:10.1016/0005-2728(85)90045-3 |
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| 86 | Verkleij, A. J., Van Venetië, R., Leunissen-Bijvelt, J., De Kruijff, B., Hope, M., & Cullis, P. R. (1985). Membrane Fusion and Lipid Polymorphism. In F. Conti, W. E. Blumberg, J. de Gier, & F. Pocchiari (Eds.), Physical Methods on Biological Membranes and Their Model Systems (pp. 179-192). Boston, MA: Springer US |
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| 85 | Mayer, L. D., Hope, M. J., Cullis, P. R., & Janoff, A. S. (1985). Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochimica et biophysica acta, 817(1), 193-196. doi:10.1016/0005-2736(85)90084-7 |
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| 84 | Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1985). Uptake of dibucaine into large unilamellar vesicles in response to a membrane potential. Journal of Biological Chemistry, 260(2), 802-808 |
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| 83 | Mayer, L. D., Bally, M. B., Hope, M. J., & Cullis, P. R. (1985). Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential. Biochimica et biophysica acta, 816(2), 294-302. doi:10.1016/0005-2736(85)90497-3 |
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| 82 | Madden, T. D., & Cullis, P. R. (1985). Preparation of reconstituted cytochrome oxidase vesicles with defined trans-membrane protein orientations employing a cytochrome c affinity column. Biochimica et biophysica acta, 808(2), 219-224. doi:10.1016/0005-2728(85)90002-7 |
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| 81 | Madden, T. D., Bally, M. B., Hope, M. J., Cullis, P. R., Schieren, H. P., & Janoff, A. S. (1985). Protection of large unilamellar vesicles by trehalose during dehydration: retention of vesicle contents. Biochimica et biophysica acta, 817(1), 67-74. doi:10.1016/0005-2736(85)90069-0 |
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| 80 | Hope, M. J., Bally, M. B., Webb, G., & Cullis, P. R. (1985). Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochimica et biophysica acta, 812(1), 55-65. doi:10.1016/0005-2736(85)90521-8 |
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| 79 | Gruner, S. M., Cullis, P. R., Hope, M. J., & Tilcock, C. P. S. (1985). Lipid Polymorphism: The Molecular Basis of Nonbilayer Phases. Annual Review of Biophysics and Biophysical Chemistry, 14(1), 211-238. doi:10.1146/annurev.bb.14.060185.001235 |
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| 78 | De Kruijff, B., Cullis, P. R., Verkleij, A. J., Hope, M. J., Van Echteld, C. J. A., & Taraschi, T. F. (1985). Lipid Polymorphism and Membrane Function. In A. N. Martonosi (Ed.), The Enzymes of Biological Membranes: Membrane Structure and Dynamics (Vol. 1, pp. 131-204). Boston, MA: Springer US |
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| 77 | Cullis, P. R., Hope, M. J., & Taraschi, T. F. (1985). Modulation of lipid polymorphism by lipid-protein interactions. Progress in protein-lipid interactions, 1, 89-142 | |
| 76 | Cullis, P. R., Hope, M. J., Nayar, R., & Tilcock, C. P. S. (1985). Roles of Phospholipids in Exocytosis (G. B. Ansell, G. Porcellati, & L. A. Horrocks Eds.). New York: Raven Press | |
| 75 | Cullis, P. R., Hope, M. J., Nayar, R., Bally, M. B., & Tilcock, C. P. S. (1985). Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure (G. B. Ansell, G. Porcellati, & L. A. Horrocks Eds.). Vol. 2: Physiological Roles | |
| 74 | Cullis, P. R., Hope, M. J., De Kruijff, B., Verkleij, A. J., & Tilcock, C. P. S. (1985). Structural Properties and Functional Roles of Phospholipids in Membranes. In Phospholipids and Cellular Regulation. Boca Raton: CRC Press. | |
| 73 | Cullis, P. R., & Hope, M. J. (1985). Physical Properties and Functional Roles of Lipids in Membranes (D. E. Vance & J. E. Vance Eds.). Menlo Park: Benjamin/Cummings |
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| 72 | Bally, M. B., Hope, M. J., Van Echteld, C. J. A., & Cullis, P. R. (1985). Uptake of safranine and other lipophilic cations into model membrane systems in response to a membrane potential. Biochimica et biophysica acta, 812(1), 66-76. doi:10.1016/0005-2736(85)90522-X |
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| 71 | Verkleij, A. J., Leunissen-Bijvelt, L., De Kruijff, B., Hope, M. J., & Cullis, P. R. (1984). Non-Bilayer Structures in Membrane Fusion. In Ciba Foundation Symposium ‐ Cell Fusion (Vol. 103, pp. 45-59) |
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| 70 | Tilcock, C. P. S., Hope, M. J., & Cullis, P. R. (1984). Influence of cholesterol esters of varying unsaturation on the polymorphic phase preferences of egg phosphatidylethanolamine. Chemistry and Physics of Lipids, 35(4), 363-370. doi:10.1016/0009-3084(84)90078-1 |
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| 69 | Tilcock, C. P. S., Bally, M. B., Farren, S. B., Cullis, P. R., & Gruner, S. M. (1984). Cation-dependent segregation phenomena and phase behavior in model membrane systems containing phosphatidylserine: influence of cholesterol and acyl chain composition. Biochemistry, 23(12), 2696-2703. doi:10.1021/bi00307a025 |
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| 68 | Sommerman, E. F., Pritchard, P. H., & Cullis, P. R. (1984). 125I labelled inulin: a convenient marker for deposition of liposomal contents in vivo. Biochemical and Biophysical Research Communications, 122(1), 319-324. doi:10.1016/0006-291x(84)90477-7 |
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| 67 | Nayar, R., Mayer, L. D., Hope, M. J., & Cullis, P. R. (1984). Phosphatidic acid as a calcium ionophore in large unilamellar vesicle systems. Biochimica et biophysica acta, 777(2), 343-346. doi:10.1016/0005-2736(84)90438-3 |
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| 66 | Madden, T. D., Hope, M. J., & Cullis, P. R. (1984). Influence of vesicle size and oxidase content on respiratory control in reconstituted cytochrome oxidase vesicles. Biochemistry, 23(7), 1413-1418. doi:10.1021/bi00302a012 |
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| 65 | Madden, T. D., & Cullis, P. R. (1984). Detergent-induced solubilization of cytochrome c oxidase as detected in a novel reconstituted system. Journal of Biological Chemistry, 259(12), 7655-7658 |
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| 64 | Farren, S. B., Sommerman, E., & Cullis, P. R. (1984). Production of specifically deuterium labelled dioleoyl phospholipid species in gram quantities: A convenient synthesis of [C[11-2H2]oleic acid. Chemistry and Physics of Lipids, 34(3), 279-286. doi:10.1016/0009-3084(84)90062-8 |
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| 63 | Madden, T. D., Hope, M. J., & Cullis, P. R. (1983). Lipid requirements for coupled cytochrome oxidase vesicles. Biochemistry, 22(8), 1970-1974. doi:10.1021/bi00277a036 |
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| 62 | Hope, M. J., Walker, D. C., & Cullis, P. R. (1983). Ca2+ and pH induced fusion of small unilamellar vesicles consisting of phosphatidylethanolamine and negatively charged phospholipids: a freeze fracture study. Biochemical and Biophysical Research Communications, 110(1), 15-22. doi:10.1016/0006-291x(83)91253-6 |
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| 61 | Farren, S. B., Hope, M. J., & Cullis, P. R. (1983). Polymorphic phase preferences of phosphatidic acid: A 31P and 2H NMR study. Biochemical and Biophysical Research Communications, 111(2), 675-682. doi:10.1016/0006-291x(83)90359-5 |
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| 60 | Cullis, P. R., De Kruijff, B., Hope, M. J., Verkleij, A. J., Nayar, R., Farren, S. B., Tilcock, C. P. S., Madden, T. D., & Bally, M. B. (1983). Structural Properties of Lipids and Their Functional Roles in Biological Membranes. In R. C. Aloia (Ed.), Concepts of Membrane Structure (pp. 39-81). New York: Academic Press. |
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| 59 | Bally, M. B., Tilcock, C. P. S., Hope, M. J., & Cullis, P. R. (1983). Polymorphism of phosphatidylethanolamine-phosphatidylserine model systems: influence of cholesterol and Mg2+ on Ca2+-triggered bilayer to hexagonal (HII) transitions. Canadian Journal of Biochemistry and Cell Biology, 61, 346-352 |
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| 58 | Tilcock, C. P. S., & Cullis, P. R. (1982). The polymorphic phase behaviour and miscibility properties of synthetic phosphatidylethanolamines. Biochimica et biophysica acta, 684(2), 212-218. doi:10.1016/0005-2736(82)90008-6 |
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| 57 | Tilcock, C. P. S., Bally, M. B., Farren, S. B., & Cullis, P. R. (1982). Influence of cholesterol on the structural preferences of dioleoylphosphatidylethanolamine-dioleoylphosphatidylcholine systems: a phosphorus-31 and deuterium nuclear magnetic resonance study. Biochemistry, 21(19), 4596-4601. doi:10.1021/bi00262a013 |
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| 56 | Nayar, R., Schmid, S. L., Hope, M. J., & Cullis, P. R. (1982). Structural preferences of phosphatidylinositol and phosphatidylinositol-phosphatidylethanolamine model membranes. Influence of Ca2+ and Mg2+. Biochimica et biophysica acta, 688(1), 169-176. doi:10.1016/0005-2736(82)90592-2 |
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| 55 | Nayar, R., Hope, M. J., & Cullis, P. R. (1982). Phospholipids as adjuncts for calcium ion stimulated release of chromaffin granule contents: implications for mechanisms of exocytosis. Biochemistry, 21(19), 4583-4589. doi:10.1021/bi00262a011 |
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| 54 | Madden, T. D., & Cullis, P. R. (1982). Stabilization of bilayer structure for unsaturated phosphatidylethanolamines by detergents. Biochimica et biophysica acta, 684(1), 149-153. doi:10.1016/0005-2736(82)90061-X |
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| 53 | Hemminga, M. A., & Cullis, P. R. (1982). 31P NMR studies of oriented phospholipid multilayers. Journal of Magnetic Resonance (1969), 47(2), 307-323. doi:10.1016/0022-2364(82)90122-6 |
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| 52 | De Kruijff, B., Nayar, R., & Cullis, P. R. (1982). 31P-NMR studies on phospholipid structure in membranes of intact, functionally-active, rat liver mitochondria. Biochimica et biophysica acta, 684(1), 47-52. doi:10.1016/0005-2736(82)90047-5 |
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| 51 | De Kruijff, B., Cullis, P. R., & Verkleij, A. J. (1982). Structural and Functional Aspects of Nonbilayer Lipids. In A. N. Martonosi (Ed.), Membranes and Transport: Volume 1 (pp. 43-49). Boston, MA: Springer US |
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| 50 | Tilcock, C. P. S., & Cullis, P. R. (1981). The polymorphic phase behavior of mixed phosphatidylserine-phosphatidylethanolamine model systems as detected by 31P-NMR. Effects of divalent cations and pH. Biochimica et biophysica acta, 641(1), 189-201. doi:10.1016/0005-2736(81)90583-6 |
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| 49 | Hornby, A. P., & Cullis, P. R. (1981). Influence of local and neutral anaesthetics on the polymorphic phase preferences of egg yolk phosphatidylethanolamine. Biochimica et biophysica acta, 647(2), 285-292. doi:10.1016/0005-2736(81)90256-X |
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| 48 | Hope, M. J., & Cullis, P. R. (1981). The role of nonbilayer lipid structures in the fusion of human erythrocytes induced by lipid fusogens. Biochimica et Biophysica Acta 640(1), 82-90. doi:10.1016/0005-2736(81)90533-2 |
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| 47 |
De Kruijff, B., Verkleij, A. J., V an Echteld, C. J. A., Gerritsen, W. J., Noordam, P. C., Mombers, C., Rietveld, A., de Gier, J., Cullis, P. R., Hope, M. J., & Nayar, R. (1981). Non-bilayer Lipids and the Inner Mitochondrial Membrane. In H. G. Schweiger (Ed.), International Cell Biology 1980–1981: Papers Presented at the Second International Congress on Cell Biology Berlin (West), August 31 – September 5, 1980 (pp. 559-571). Berlin, Heidelberg: Springer Berlin Heidelberg |
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| 46 | De Kruijff, B., Verkleij, A. J., Van Echteld, C. J. A., De Gier, J., & Cullis, P. R. (1981). Lipid Polymorphism and the Occurrence of Non-Bilayer Phases in Model and Biological Membranes, 1981 (B. e. al. Ed.): North Holland Publishing Co |
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| 45 | Cullis, P. R., Farren, S. B., & Hope, M. J. (1981). 31P NMR Techniques and Membrane Lipid Structure: Implications for Mechanisms of Membrane Fusion. Canadian Journal of Spectroscopy, 26, 89-94 | |
| 44 | Cullis, P. R. (1981). Chapter 4 - The Lipid Bilayer, Mechanisms of Fusion and Transmembrane Transport. In S. Wolf & A. K. Murray (Eds.), Advances in Experimental Medicine and Biology - Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases (Vol. 140, pp. 137-186). New York: Plenum Press. |
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| 43 | Verkleij, A. J., Van Echteld, C. J. A., Gerritsen, W. J., Cullis, P. R., & De Kruijff, B. (1980). The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions. Biochimica et biophysica acta, 600(3), 620-624. doi:10.1016/0005-2736(80)90465-4 |
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| 42 | Hope, M. J., & Cullis, P. R. (1980). Effects of divalent cations and pH on phosphatidylserine model membranes: A 31P NMR study. Biochemical and Biophysical Research Communications, 92(3), 846-852. doi:10.1016/0006-291X(80)90780-9 |
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| 41 | Farren, S. B., & Cullis, P. R. (1980). Polymorphism of phosphatidylglycerol-phosphatidylethanolamine model membrane systems: A 31P NMR study. Biochemical and Biophysical Research Communications, 97(1), 182-191. doi:10.1016/S0006-291X(80)80152-5 |
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| 40 | De Kruijff, B., Rietveld, A., & Cullis, P. R. (1980). 31P-NMR studies on membrane phospholipids in microsomes, rat liver slices and intact perfused rat liver. Biochimica et Biophysica Acta 600(2), 343-357. doi:10.1016/0005-2736(80)90438-1 |
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| 39 | De Kruijff, B., Morris, G. A., & Cullis, P. R. (1980). Application of 31P-NMR saturation transfer techniques to investigate phospholipid motion and organization in model and biological membranes. Biochimica et biophysica acta, 598(1), 206-211. doi:10.1016/0005-2736(80)90281-3 |
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| 38 | De Kruijff, B., Cullis, P. R., Verkleij, A. J., Vanechteld, C. J. A., Gerritsen, W. J., Mombers, C., Noordam, P. C., & Gier, J. D. (1980). Structural and functional roles of lipids in model and biological-membranes. European Journal of Cell Biology, 22(1), 217 | |
| 37 | De Kruijff, B., Cullis, P. R., & Verkleij, A. J. (1980). Non-bilayer lipid structures in model and biological membranes. Trends in Biochemical Sciences, 5(3), 79-81. doi:10.1016/0968-0004(80)90074-2 |
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| 36 | De Kruijff, B., & Cullis, P. R. (1980). The influence of poly(l-lysine) on phospholipid polymorphism - Evidence that electrostatic polypeptide-phospholipid interactions can modulate bilayer/non-bilayer transitions. Biochimica et biophysica acta, 601, 235-240. doi:10.1016/0005-2736(80)90528-3 |
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| 35 | De Kruijff, B., & Cullis, P. R. (1980). Cytochrome c specifically induces non-bilayer structures in cardiolipin-containing model membranes. Biochimica et biophysica acta, 602(3), 477-490. doi:10.1016/0005-2736(80)90327-2 |
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| 34 | Cullis, P. R., De Kruijff, B., Hope, M. J., Nayar, R., & Schmid, S. L. (1980). Phospholipids and membrane transport. Canadian Journal of Biochemistry, 58(10), 1091-1100. doi:10.1139/o80-147 |
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| 33 | Cullis, P. R., Hornby, A. P., & Hope, M. J. (1980). Effects of Anesthetics on Lipid Polymorphism (B. R. Fink Ed. Vol. 2: Progress in Anaesthesiology). New York: Raven Press |
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| 32 | Cullis, P. R., & Hope, M. J. (1980). The bilayer stabilizing role of sphingomyelin in the presence of cholesterol. A 31P NMR study. Biochimica et biophysica acta, 597(3), 533-542. doi:10.1016/0005-2736(80)90225-4 |
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| 31 | Cullis, P. R., De Kruijff, B., Hope, M. J., Nayar, R., Rietveld, A., & Verkleij, A. J. (1980). Structural properties of phospholipids in the rat liver inner mitochondrial membrane. A 31P-NMR study. Biochimica et biophysica acta, 600(3), 625-635. doi:10.1016/0005-2736(80)90466-6 |
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| 30 | Burnell, E. E., Cullis, P. R., & De Kruijff, B. (1980). Effects of tumbling and lateral diffusion on phosphatidylcholine model membrane 31P-NMR lineshapes. Biochimica et biophysica acta, 603(1), 63-69. doi:10.1016/0005-2736(80)90391-0 |
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| 29 | Verkleij, A. J., Mombers, C., Gerritsen, W. J., Leunissen-Bijvelt, L., & Cullis, P. R. (1979). Fusion of phospholipid vesicles in association with the appearance of lipidic particles as visualized by freeze fracturing. Biochimica et Biophysica Acta (BBA) - Biomembranes, 555(2), 358-361. doi:10.1016/0005-2736(79)90175-5 |
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| 28 | Hope, M. J., & Cullis, P. R. (1979). The bilayer stability of inner monolayer lipids from the human erythrocyte. FEBS Letters, 107(2), 323-326. doi:10.1016/0014-5793(79)80399-3 |
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| 27 | Cullis, P. R., & Verkleij, A. J. (1979). Modulation of membrane structure by Ca2+ and dibucaine as detected by 31P NMR. Biochimica et Biophysica Acta, 552(3), 546-551. doi:10.1016/0005-2736(79)90200-1 |
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| 26 | Cullis, P. R., & De Kruijff, B. (1979). Lipid polymorphism and the functional roles of lipids in biological membranes. Biochimica et Biophysica Acta, 559(4), 399-420. doi:10.1016/0304-4157(79)90012-1 |
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| 25 | De Kruijff, B., van den Besselaar, A. M., Cullis, P. R., van den Bosch, H., & van Deenen, L. L. (1978). Evidence for isotropic motion of phospholipids in liver microsomal membranes. A 31P NMR study. Biochimica et Biophysica Acta, 514(1), 1-8. doi:10.1016/0005-2736(78)90072-x |
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| 24 | Cullis, P. R., Verkleij, A. J., & Ververgaert, P. H. J. T. (1978). Polymorphic phase behaviour of cardiolipin as detected by 31P NMR and freeze-fracture techniques. Effects of calcium, dibucaine and chlorpromazine. Biochimica et Biophysica Acta (BBA), 513(1), 11-20. doi:10.1016/0005-2736(78)90107-4 |
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| 23 | Cullis, P. R., Van Dijck, P. W. M., De Kruijff, B., & De Gier, J. (1978). Effects of cholesterol on the properties of equimolar mixtures of synthetic phosphatidylethanolamine and phosphatidylcholine. A 31P NMR and differential scanning calorimetry study. Biochimica et Biophysica Acta, 513(1), 21-30. doi:10.1016/0005-2736(78)90108-6 |
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| 22 | Cullis, P. R., & Hope, M. J. (1978). Effects of fusogenic agent on membrane structure of erythrocyte ghosts and the mechanism of membrane fusion. Nature, 271(5646), 672-674. doi:10.1038/271672a0 |
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| 21 | Cullis, P. R., & De Kruijff, B. (1978). The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study. Biochimica et Biophysica Acta, 513(1), 31-42. doi:10.1016/0005-2736(78)90109-8 |
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| 20 | Cullis, P. R., & De Kruijff, B. (1978). Polymorphic phase behaviour of lipid mixtures as detected by 31P NMR. Evidence that cholesterol may destabilize bilayer structure in membrane systems containing phosphatidylethanolamine. Biochimica et Biophysica Acta, 507(2), 207-218. doi:10.1016/0005-2736(78)90417-0 |
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| 19 | Sim, E., & Cullis, P. R. (1977). 31P Nuclear magnetic resonance studies of cell membranes labelled with phosphonium phosphatidylcholine. FEBS Letters, 79(2), 340-344. doi:10.1016/0014-5793(77)80816-8 |
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| 18 | McLaughlin, A. C., Cullis, P. R., Hemminga, M. A., Brown, F. F., & Brocklehurst, J. (1977). Magnetic Resonance Studies of Model and Biological Membranes (R. A. Dwek, I. D. Campbell, R. E. Richards, & R. J. P. Williams Eds.): Academic Press | |
| 17 | Cullis, P. R., & McLaughlin, A. C. (1977). Phosphorus nuclear magnetic resonance studies of model and biological membranes. Trends in Biochemical Sciences, 2(9), 196-199. |
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| 16 | Cullis, P. R., & Grathwohl, C. (1977). Hydrocarbon phase transitions and lipid-protein interactions in the erythrocyte membrane. A 31P NMR and fluorescence study. Biochimica et Biophysica Acta, 471(2), 213-226. doi:10.1016/0005-2736(77)90251-6 |
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| 15 | Cullis, P. R., De Kruijff, B., McGrath, A. E., Morgan, C. G., & Radda, G. K. (1977). Lipid Asymmetry, Clustering and Molecular Motion in Biological Membranes and Their Models. In S. Abrahamsson & I. Pascher (Eds.), Structure of Biological Membranes (pp. 389-407). Boston, MA: Springer US |
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| 14 | De Kruijff, B., Cullis, P. R., Radda, G. K., & Richards, R. E. (1976). Phosphorus nuclear magnetic resonance of Acholeplasma laidlawii cell membranes and derived liposomes. Biochimica et Biophysica Acta, 419(3), 411-424. doi:10.1016/0005-2736(76)90255-8 |
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| 13 | De Kruijff, B., Cullis, P. R., & Radda, G. K. (1976). Outside-inside distributions and sizes of mixed phosphatidylcholine-cholesterol vesicles. Biochimica et Biophysica Acta, 436(4), 729-740. doi:10.1016/0005-2736(76)90402-8 |
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| 12 | Cullis, P. R., De Kruyff, B., & Richards, R. E. (1976). Factors affecting the motion of the polar headgroup in phospholipid bilayers. A 31P NMR study of unsonicated phosphatidylcholine liposomes. Biochimica et Biophysica Acta, 426(3), 433-446. doi:10.1016/0005-2736(76)90388-6 |
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| 11 | Cullis, P. R., & De Kruyff, B. (1976). 31P NMR studies of unsonicated aqueous dispersions of neutral and acidic phospholipids. Effects of phase transitions, p2H and divalent cations on the motion in the phosphate region of the polar headgroup. Biochimica et Biophysica Acta, 436(3), 523-540. doi:10.1016/0005-2736(76)90438-7 |
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| 10 | Cullis, P. R. (1976). Lateral diffusion rates of phosphatidylcholine in vesicle membranes: Effects of cholesterol and hydrocarbon phase transitions. FEBS Letters, 70(1), 223-228. doi:10.1016/0014-5793(76)80762-4 |
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| 9 | Cullis, P. R. (1976). Hydrocarbon phase transitions, heterogeneous lipid distributions and lipid—protein interactions in erythrocyte membranes. FEBS Letters, 68(2), 173-176. doi:10.1016/0014-5793(76)80430-9 |
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| 8 | Cullis, P. R. (1976). Electron paramagnetic resonance in inhomogeneously broadened systems: A spin temperature approach. Journal of Magnetic Resonance (1969), 21(3), 397-418. doi:10.1016/0022-2364(76)90044-5 |
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| 7 | Sim, E., Cullis, P. R., & Richards, R. E. (1975). Physical studies on phosphonium phosphatidylcholine. A unique [31P]phosphorus nuclear-magnetic-resonance probe for model and biological membranes. The Biochemical Journal, 151(3), 555-560. doi:10.1042/bj1510555 |
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| 6 | McLaughlin, A. C., Cullis, P. R., Hemminga, M. A., Hoult, D. I., Radda, G. K., Ritchie, G. A., Seeley, P. J., & Richards, R. E. (1975). Application of 31P NMR to model and biological membrane systems. FEBS Letters, 57(2), 213-218. doi:10.1016/0014-5793(75)80719-8 |
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| 5 | McLaughlin, A. C., Cullis, P. R., Berden, J. A., & Richards, R. E. (1975). 31P NMR of Phospholipid membranes: Effects of chemical and anisotropy at high magnetic field strengths. Journal of Magnetic Resonance (1969), 20(1), 146-165. doi:10.1016/0022-2364(75)90162-6 |
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| 4 | De Kruijff, B., Cullis, P. R., & Radda, G. K. (1975). Differential scanning calorimetry and 31P NMR studies on sonicated and unsonicated phosphatidylcholine liposomes. Biochimica et Biophysica Acta, 406(1), 6-20. doi:10.1016/0005-2736(75)90038-3 |
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| 3 | Cullis, P. R., & Marko, J. R. (1975). Electron paramagnetic resonance properties of n-type silicon in the intermediate impurity-concentration range. Physical Review B, 11(11), 4184-4200. doi:10.1103/PhysRevB.11.4184 |
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| 2 | Berden, J. A., Cullis, P. R., Hoult, D. I., McLaughlin, A. C., Radda, G. K., & Richards, R. E. (1974). Frequency dependence of 31P NMR linewidths in sonicated phospholipid vesicles: Effects of chemical shift anisotropy. FEBS Letters, 46(1), 55-58. doi:10.1016/0014-5793(74)80333-9 |
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| 1 | Cullis, P. R., & Marko, J. R. (1970). Determination of the Donor Pair Exchange Energy in Phosphorus-Doped Silicon. Physical Review B, 1(2), 632-637. doi:10.1103/PhysRevB.1.632 |
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